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T40.5X4 vs T40.5X5

T40.5X4 (Poisoning by cocaine, undetermined) compared with T40.5X5 (Adverse effect of cocaine), from the official CMS tabular data. T40.5X4 and T40.5X5 code the same substance (Coca) with a different intent.

Relationship

Informational

Drug table relationship

T40.5X4
Poisoning by cocaine, undetermined
T40.5X5
Adverse effect of cocaine

Same substance, different circumstance of exposure.

Same substance — adverse effect (Coca)

Accidental poisoning, intentional self-harm, assault, undetermined intent, adverse effect and underdosing are mutually exclusive columns — exactly one applies to a given encounter.

Source: CMS Table of Drugs and Chemicals

Can these codes be reported together?

Same substance, different intent. T40.5X4 and T40.5X5 code the same substance (Coca) with a different circumstance of exposure.

From the CMS Table of Drugs and Chemicals: accidental poisoning, intentional self-harm, assault, undetermined intent, adverse effect and underdosing are mutually exclusive columns — only one of them applies to a given encounter.

Side by side

T40.5X4Poisoning by cocaine, undeterminedT40.5X5Adverse effect of cocaine
Billing statusNon-billable header

Report instead: T40.5X4A, T40.5X4D, T40.5X4S

Non-billable header

Report instead: T40.5X5A, T40.5X5D, T40.5X5S

ClassificationS00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)
DefinitionPoisoning by cocaine, undetermined is a non-billable ICD-10-CM category code (T40.5X4).Adverse effect of cocaine is a non-billable ICD-10-CM category code (T40.5X5).
7th characterThe appropriate 7th character is to be added to each code from category T40The appropriate 7th character is to be added to each code from category T40
Includes
adverse effect of correct substance properly administered
poisoning by overdose of substance
poisoning by wrong substance given or taken in error
underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
adverse effect of correct substance properly administered
poisoning by overdose of substance
poisoning by wrong substance given or taken in error
underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Use additional code
code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
Code first
, for adverse effects, the nature of the adverse effect, such as:
adverse effect NOS (T88.7)
, for adverse effects, the nature of the adverse effect, such as:
adverse effect NOS (T88.7)

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources