T43.22 vs T43.221A
T43.22 (Poisoning by, adverse effect of and underdosing of selective serotonin reuptake inhibitors) compared with T43.221A (Poisoning by selective serotonin reuptake inhibitors, accidental (unintentional), initial encounter), from the official CMS tabular data.
Summary
These codes represent different levels of the same hierarchy: T43.22 is the non-billable header that contains T43.221A, so only T43.221A (or a sibling) is reported.
Registry fact- What is different?
Title wording and billing status.The titles share “Poisoning by”; T43.22 says “adverse effect of and underdosing of selective serotonin reuptake inhibitors” where T43.221A says “selective serotonin reuptake inhibitors, accidental (unintentional), initial encounter”. T43.22 is a non-billable header; T43.221A is billable.
Registry fact
- Can these codes be reported together?
Not as a pair.T43.22 is the non-billable header that contains T43.221A. A header is not reported on a claim, so the choice is T43.221A or a sibling that matches the documentation.
Registry fact
- Is there an Excludes1 relationship?
None.Neither entry carries an Excludes1 note that names the other code. T43.22 carries 1 Excludes1 note and T43.221A carries 1 Excludes1 note covering other codes; the side-by-side table quotes them.
Official rule
- Is there an Excludes2 relationship?
None.Neither entry carries an Excludes2 note that names the other code. T43.22 carries 11 Excludes2 notes and T43.221A carries 11 Excludes2 notes covering other codes; the side-by-side table quotes them.
Official rule
- Is one more specific?
Yes.T43.221A is a subdivision of T43.22 in the tabular hierarchy, so it is the more specific of the two.
Registry fact
- Is one a parent or header code?
Yes.T43.22 is the non-billable header that contains T43.221A. A header stands for the whole family beneath it and is not reported on a claim.
Registry fact
- Are there sequencing instructions?
None.Neither entry carries a Code First or Use Additional Code note that names the other.
Official rule
- Are there other coding relationships?
None found.No laterality, encounter-phase, Table of Neoplasms, Table of Drugs and Chemicals, or history-versus-active-disease relationship links these codes.
MedCoder-derived
Official rule: a tabular instructional note or a section of the ICD-10-CM Official Guidelines, quoted as published. Registry fact: the codes’ own published attributes (titles, billable status, position in the hierarchy, code set). MedCoder-derived: a reading MedCoder computes from those facts; it is not itself a rule. How to read the labels
Can these codes be reported together?
Not as a pair — T43.22 is not reportable. T43.22 is the non-billable category that contains T43.221A.
A header stands for the whole family of codes beneath it and is not reported on a claim, so the choice is T43.221A or a sibling that matches the documentation. No Excludes1/Excludes2 relationship exists between these codes in the official tabular list.
Official guidance behind these answers
Section I.B.2 — Level of Detail in Coding · applies to: T43.22 and T43.221A
Diagnosis codes are to be used and reported at their highest number of characters available and to the highest level of specificity documented in the medical record. ICD-10-CM diagnosis codes are composed of codes with 3, 4, 5, 6 or 7 characters. Codes with three characters are included in ICD-10-CM as the heading of a category of codes that may be further subdivided by the use of fourth and/or fifth characters and/or sixth characters, which provide greater detail. A three-character code is to be used only if it is not further subdivided. A code is invalid if it has not been coded to the full number of characters required for that code, including the 7th character, if applicable.
ICD-10-CM Official Guidelines FY2026
Quoted from the ICD-10-CM Official Guidelines for Coding and Reporting in effect for the release shown. The tabular notes above are the code-level instruction; these sections are the convention that says how such a note is applied. Source document (CMS PDF) · Release and checksum
Side by side
| T43.22Poisoning by, adverse effect of and underdosing of selective serotonin reuptake inhibitors | T43.221APoisoning by selective serotonin reuptake inhibitors, accidental (unintentional), initial encounter | |
|---|---|---|
| Billing status | Non-billable header Report instead: T43.221A, T43.221D, T43.221S, T43.222A, T43.222D | Billable |
| Classification | S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88) | S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88) |
| Definition | Poisoning by, adverse effect of and underdosing of selective serotonin reuptake inhibitors is a non-billable ICD-10-CM category code (T43.22). | Poisoning by selective serotonin reuptake inhibitors, accidental (unintentional), initial encounter is a billable ICD-10-CM diagnosis code (T43.221A). |
| 7th character | The appropriate 7th character is to be added to each code from category T43 | The appropriate 7th character is to be added to each code from category T43 |
| Includes | adverse effect of correct substance properly administered poisoning by overdose of substance poisoning by wrong substance given or taken in error underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed | adverse effect of correct substance properly administered poisoning by overdose of substance poisoning by wrong substance given or taken in error underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed |
| Excludes1 | toxic reaction to local anesthesia in pregnancy (O29.3-) | toxic reaction to local anesthesia in pregnancy (O29.3-) |
| Excludes2 | appetite depressants (T50.5-) barbiturates (T42.3-) benzodiazepines (T42.4-) drug dependence and related mental and behavioral disorders due to psychoactive substance use (F10.- -F19.-) methaqualone (T42.6-) psychodysleptics [hallucinogens] (T40.7-T40.9-) abuse and dependence of psychoactive substances (F10-F19) abuse of non-dependence-producing substances (F55.-) immunodeficiency due to drugs (D84.821) drug reaction and poisoning affecting newborn (P00-P96) pathological drug intoxication (inebriation) (F10-F19) | appetite depressants (T50.5-) barbiturates (T42.3-) benzodiazepines (T42.4-) drug dependence and related mental and behavioral disorders due to psychoactive substance use (F10.- -F19.-) methaqualone (T42.6-) psychodysleptics [hallucinogens] (T40.7-T40.9-) abuse and dependence of psychoactive substances (F10-F19) abuse of non-dependence-producing substances (F55.-) immunodeficiency due to drugs (D84.821) drug reaction and poisoning affecting newborn (P00-P96) pathological drug intoxication (inebriation) (F10-F19) |
| Code first | , for adverse effects, the nature of the adverse effect, such as: adverse effect NOS (T88.7) | , for adverse effects, the nature of the adverse effect, such as: adverse effect NOS (T88.7) |
| Use additional code | code(s) to specify: manifestations of poisoning underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9) | code(s) to specify: manifestations of poisoning underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9) |
Notes are the code’s own tabular entry, quoted as published. A note that names the other code is the one the verdict above rests on.
Derived from the official CMS ICD-10-CM tabular data (FY2026). A coding-rule comparison, not billing advice: payer-specific edits and medical-necessity policy are outside its scope. All data sources