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T49.5X5 vs T49.5X6

T49.5X5 (Adverse effect of ophthalmological drugs and preparations) compared with T49.5X6 (Underdosing of ophthalmological drugs and preparations), from the official CMS tabular data. T49.5X5 and T49.5X6 code the same substance (Befunolol) with a different intent.

Can these codes be reported together?

Same substance, different intent. T49.5X5 and T49.5X6 code the same substance (Befunolol) with a different circumstance of exposure.

From the CMS Table of Drugs and Chemicals: accidental poisoning, intentional self-harm, assault, undetermined intent, adverse effect and underdosing are mutually exclusive columns — only one of them applies to a given encounter.

Side by side

T49.5X5Adverse effect of ophthalmological drugs and preparationsT49.5X6Underdosing of ophthalmological drugs and preparations
Billing statusNon-billable headerNon-billable header
ClassificationS00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)
DefinitionAdverse effect of ophthalmological drugs and preparations is a non-billable ICD-10-CM category code (T49.5X5).Underdosing of ophthalmological drugs and preparations is a non-billable ICD-10-CM category code (T49.5X6).
7th characterThe appropriate 7th character is to be added to each code from category T49The appropriate 7th character is to be added to each code from category T49
Includes
poisoning by, adverse effect of and underdosing of glucocorticoids, topically used
adverse effect of correct substance properly administered
poisoning by overdose of substance
poisoning by wrong substance given or taken in error
poisoning by, adverse effect of and underdosing of glucocorticoids, topically used
adverse effect of correct substance properly administered
poisoning by overdose of substance
poisoning by wrong substance given or taken in error
Use additional code
code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
code(s) to specify:
manifestations of poisoning
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
Code first
, for adverse effects, the nature of the adverse effect, such as:
adverse effect NOS (T88.7)
, for adverse effects, the nature of the adverse effect, such as:
adverse effect NOS (T88.7)

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources