T78.3XXS vs T80.6
T78.3XXS (Angioneurotic edema, sequela) compared with T80.6 (Other serum reactions), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. T78.3XXS carries an Excludes1 note covering T80.6: “serum urticaria (T80.6-)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Yes, when both are documented. T78.3XXS carries an Excludes2 note covering T80.6: “complications of surgical and medical care NEC (T80-T88)”
Excludes2 marks distinct conditions — both may be reported when both are documented.
Side by side
| T78.3XXSAngioneurotic edema, sequela | T80.6Other serum reactions | |
|---|---|---|
| Billing status | Billable | Non-billable header |
| Classification | S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88) | S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88) |
| Definition | Angioneurotic edema, sequela is a billable ICD-10-CM diagnosis code (T78.3S). | Other serum reactions is a non-billable ICD-10-CM category code (T80.6). |
| 7th character | The appropriate 7th character is to be added to each code from category T78 | The appropriate 7th character is to be added to each code from category T80 |
| Includes | Allergic angioedema Giant urticaria Quincke's edema | complications following perfusion Intoxication by serum Protein sickness Serum rash |
| Use additional code | — | code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5) code(s) to identify the specified condition resulting from the complication code to identify devices involved and details of circumstances (Y62-Y82) |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources