T80.22XA vs T80.22XS

T80.22XA (Acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter) compared with T80.22XS (Acute infection following transfusion, infusion, or injection of blood and blood products, sequela), from the official CMS tabular data. T80.22XA and T80.22XS code the same injury at a different phase of treatment.

Relationship

Review

Encounter relationship

T80.22XA

Initial encounter

Acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter

↔

T80.22XS

Sequela

Acute infection following transfusion, infusion, or injection of blood and blood products, sequela

Same underlying diagnosis, different encounter phase.

The 7th character records the phase of care for the encounter being coded, so a single encounter takes one of these characters, not several. Review whether both phases belong on the same episode of care.

Source: ICD-10-CM Official Guidelines, Section I.C.19.a

Can these codes be reported together?

Same injury, other encounter phase. T80.22XA and T80.22XS code the same injury at a different phase of treatment, set by the 7th character.

The 7th character records the type of care given at the encounter being coded (ICD-10-CM Official Guidelines, Section I.C.19.a), so one encounter takes one of these, not both.

Side by side

	T80.22XAAcute infection following transfusion, infusion, or injection of blood and blood products, initial encounter	T80.22XSAcute infection following transfusion, infusion, or injection of blood and blood products, sequela
Billing status	Billable	Billable
Classification	S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)	S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)
Definition	Acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter is a billable ICD-10-CM diagnosis code (T80.22A).	Acute infection following transfusion, infusion, or injection of blood and blood products, sequela is a billable ICD-10-CM diagnosis code (T80.22S).
7th character	The appropriate 7th character is to be added to each code from category T80	The appropriate 7th character is to be added to each code from category T80
Includes	complications following perfusion	complications following perfusion
Use additional code	code to identify the specific infection, such as: sepsis (A41.9) code (R65.2-) to identify severe sepsis, if applicable	code to identify the specific infection, such as: sepsis (A41.9) code (R65.2-) to identify severe sepsis, if applicable

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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources