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T80.30 vs T80.39

T80.30 (ABO incompatibility reaction due to transfusion of blood or blood products, unspecified) compared with T80.39 (Other ABO incompatibility reaction due to transfusion of blood or blood products), from the official CMS tabular data.

Summary

These codes represent different levels of specificity within category T80: T80.39 is the more specific code and T80.30 is the unspecified one.

MedCoder-derived
What is different?

The conditions named.T80.30 is “ABO incompatibility reaction due to transfusion of blood or blood products, unspecified”; T80.39 is “Other ABO incompatibility reaction due to transfusion of blood or blood products”.

Registry fact

Can these codes be reported together?

Not ordinarily.T80.39 is the more specific code and T80.30 is the unspecified one, in the same category. When the documentation supports the more specific code, the unspecified code is not added for the same condition (ICD-10-CM Official Guidelines, Section I.B.18).

MedCoder-derivedGuide: Other vs unspecified (NEC vs NOS)

Is there an Excludes1 relationship?

None.Neither entry carries an Excludes1 note that names the other code. T80.30 carries 1 Excludes1 note and T80.39 carries 1 Excludes1 note covering other codes; the side-by-side table quotes them.

Official rule

Is there an Excludes2 relationship?

None.Neither entry carries an Excludes2 note that names the other code. T80.30 carries 28 Excludes2 notes and T80.39 carries 28 Excludes2 notes covering other codes; the side-by-side table quotes them.

Official rule

Is one more specific?

Yes.T80.39’s title names the condition; T80.30’s title is the unspecified form (“ABO incompatibility reaction due to transfusion of blood or blood products, unspecified”).

MedCoder-derivedGuide: Other vs unspecified (NEC vs NOS)

Is one a parent or header code?

Both are headers.Both are non-billable headers, and neither contains the other.

Registry fact

Are there sequencing instructions?

None.Neither entry carries a Code First or Use Additional Code note that names the other.

Official rule

Are there other coding relationships?

None found.No laterality, encounter-phase, Table of Neoplasms, Table of Drugs and Chemicals, or history-versus-active-disease relationship links these codes.

MedCoder-derived

Official rule: a tabular instructional note or a section of the ICD-10-CM Official Guidelines, quoted as published. Registry fact: the codes’ own published attributes (titles, billable status, position in the hierarchy, code set). MedCoder-derived: a reading MedCoder computes from those facts; it is not itself a rule. How to read the labels

Can these codes be reported together?

Review

Specificity relationship

T80.30
ABO incompatibility reaction due to transfusion of blood or blood products, unspecified
T80.39
Other ABO incompatibility reaction due to transfusion of blood or blood products

What we found

Not ordinarily reported together for the same condition. No Excludes1/Excludes2 relationship is listed between T80.30 and T80.39, but they describe overlapping diagnoses in the same category (Both are children of the same T80 category.).

When documentation supports the more specific code, the unspecified code should generally not be added for the same condition (ICD-10-CM Official Guidelines, Section I.B.18).

What to review

When the documentation supports the more specific code, report it and leave the unspecified code off for the same condition.

Guide: Other vs unspecified (NEC vs NOS)Check these on a claim

Why it matters

No Excludes note links these codes, but they describe overlapping diagnoses and one of them is unspecified. When documentation supports the more specific code, the unspecified code should generally not be added for the same condition.

Source / rule

ICD-10-CM Official Guidelines, Section I.B.18

Official guidance behind these answers

  • Section I.B.18 — Use of Sign/Symptom/Unspecified Codes · applies to: Unspecified codes

    Sign/symptom and “unspecified” codes have acceptable, even necessary, uses. While specific diagnosis codes should be reported when they are supported by the available medical record documentation and clinical knowledge of the patient’s health condition, there are instances when signs/symptoms or unspecified codes are the best choices for accurately reflecting the healthcare encounter. Each healthcare encounter should be coded to the level of certainty known for that encounter. As stated in the introductory section of these official coding guidelines, a joint effort between the healthcare provider and the coder is essential to achieve complete and accurate documentation, code assignment, and reporting of diagnoses and procedures. The importance of consistent, complete documentation in the medical record cannot be overemphasized. Without such documentation accurate coding cannot be achieved. The entire record should be reviewed to determine the specific reason for the encounter and the conditions treated. If a definitive diagnosis has not been established by the end of the encounter, it is appropriate to report codes for sign(s) and/or symptom(s) in lieu of a definitive diagnosis. When sufficient clinical information isn’t known or available about a particular health condition to assign a more specific code, it is acceptable to report the appropriate “unspecified” code (e.g., a diagnosis of pneumonia has been determined, but not the specific type). […]

    ICD-10-CM Official Guidelines FY2026

  • Section I.B.2 — Level of Detail in Coding · applies to: Level of detail

    Diagnosis codes are to be used and reported at their highest number of characters available and to the highest level of specificity documented in the medical record. ICD-10-CM diagnosis codes are composed of codes with 3, 4, 5, 6 or 7 characters. Codes with three characters are included in ICD-10-CM as the heading of a category of codes that may be further subdivided by the use of fourth and/or fifth characters and/or sixth characters, which provide greater detail. A three-character code is to be used only if it is not further subdivided. A code is invalid if it has not been coded to the full number of characters required for that code, including the 7th character, if applicable.

    ICD-10-CM Official Guidelines FY2026

Quoted from the ICD-10-CM Official Guidelines for Coding and Reporting in effect for the release shown. The tabular notes above are the code-level instruction; these sections are the convention that says how such a note is applied. Source document (CMS PDF) · Release and checksum

Side by side

T80.30ABO incompatibility reaction due to transfusion of blood or blood products, unspecifiedT80.39Other ABO incompatibility reaction due to transfusion of blood or blood products
Billing statusNon-billable header

Report instead: T80.30XA, T80.30XD, T80.30XS

Non-billable header

Report instead: T80.39XA, T80.39XD, T80.39XS

ClassificationS00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)
DefinitionABO incompatibility reaction due to transfusion of blood or blood products, unspecified is a non-billable ICD-10-CM category code (T80.30).Other ABO incompatibility reaction due to transfusion of blood or blood products is a non-billable ICD-10-CM category code (T80.39).
7th characterThe appropriate 7th character is to be added to each code from category T80The appropriate 7th character is to be added to each code from category T80
Includes
complications following perfusion
ABO incompatibility blood transfusion NOS
Reaction to ABO incompatibility from transfusion NOS
complications following perfusion
Delayed serologic transfusion reaction (DSTR) from ABO incompatibility
Other ABO incompatible blood transfusion
Other reaction to ABO incompatible blood transfusion
Excludes1
minor blood group antigens reactions (Duffy) (E) (K) (Kell) (Kidd) (Lewis) (M) (N) (P) (S) (T80.A-)
minor blood group antigens reactions (Duffy) (E) (K) (Kell) (Kidd) (Lewis) (M) (N) (P) (S) (T80.A-)
Excludes2
bone marrow transplant rejection (T86.01)
febrile nonhemolytic transfusion reaction (R50.84)
fluid overload due to transfusion (E87.71)
posttransfusion purpura (D69.51)
transfusion associated circulatory overload (TACO) (E87.71)
transfusion (red blood cell) associated hemochromatosis (E83.111)
transfusion related acute lung injury (TRALI) (J95.84)
any encounters with medical care for postprocedural conditions in which no complications are present, such as:
artificial opening status (Z93.-)
closure of external stoma (Z43.-)
fitting and adjustment of external prosthetic device (Z44.-)
burns and corrosions from local applications and irradiation (T20-T32)
complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
mechanical complication of respirator [ventilator] (J95.850)
poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
postprocedural fever (R50.82)
specified complications classified elsewhere, such as:
cerebrospinal fluid leak from spinal puncture (G97.0)
colostomy malfunction (K94.0-)
disorders of fluid and electrolyte imbalance (E86-E87)
functional disturbances following cardiac surgery (I97.0-I97.1)
intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
ostomy complications (J95.0-, K94.-, N99.5-)
postgastric surgery syndromes (K91.1)
postlaminectomy syndrome NEC (M96.1)
postmastectomy lymphedema syndrome (I97.2)
postsurgical blind-loop syndrome (K91.2)
ventilator associated pneumonia (J95.851)
bone marrow transplant rejection (T86.01)
febrile nonhemolytic transfusion reaction (R50.84)
fluid overload due to transfusion (E87.71)
posttransfusion purpura (D69.51)
transfusion associated circulatory overload (TACO) (E87.71)
transfusion (red blood cell) associated hemochromatosis (E83.111)
transfusion related acute lung injury (TRALI) (J95.84)
any encounters with medical care for postprocedural conditions in which no complications are present, such as:
artificial opening status (Z93.-)
closure of external stoma (Z43.-)
fitting and adjustment of external prosthetic device (Z44.-)
burns and corrosions from local applications and irradiation (T20-T32)
complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
mechanical complication of respirator [ventilator] (J95.850)
poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
postprocedural fever (R50.82)
specified complications classified elsewhere, such as:
cerebrospinal fluid leak from spinal puncture (G97.0)
colostomy malfunction (K94.0-)
disorders of fluid and electrolyte imbalance (E86-E87)
functional disturbances following cardiac surgery (I97.0-I97.1)
intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
ostomy complications (J95.0-, K94.-, N99.5-)
postgastric surgery syndromes (K91.1)
postlaminectomy syndrome NEC (M96.1)
postmastectomy lymphedema syndrome (I97.2)
postsurgical blind-loop syndrome (K91.2)
ventilator associated pneumonia (J95.851)
Use additional code
code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
code(s) to identify the specified condition resulting from the complication
code to identify devices involved and details of circumstances (Y62-Y82)
code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
code(s) to identify the specified condition resulting from the complication
code to identify devices involved and details of circumstances (Y62-Y82)

Notes are the code’s own tabular entry, quoted as published. A note that names the other code is the one the verdict above rests on.

Derived from the official CMS ICD-10-CM tabular data (FY2027). A coding-rule comparison, not billing advice: payer-specific edits and medical-necessity policy are outside its scope. All data sources