Skip to main content
ICD-10/C25.9

C25.9 ICD-10-CM Code: Malignant neoplasm of pancreas, unspecified

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.

  • MS-DRG 435 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH MCC (MDC 07)
  • MS-DRG 436 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH CC (MDC 07)
  • MS-DRG 437 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITHOUT CC/MCC (MDC 07)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 20 — Lung and Other Severe Cancers (supersedes HCC 21, HCC 22, HCC 23)

Other models: CMS-HCC V22 HCC 9 · RxHCC V08 HCC 20

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.

Official Registry Overview & Definition

Malignant neoplasm of pancreas, unspecified is a billable ICD-10-CM diagnosis code (C25.9).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for C25.9 in the official ICD-10-CM tabular list.

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

  • Kaposi's sarcoma of gastrointestinal sites (C46.4)

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

  • gastrointestinal stromal tumors (C49.A-)

Code Also

Additional codes that may be required to fully describe the encounter.

  • if applicable exocrine pancreatic insufficiency (K86.81)

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code to identify:
  • alcohol abuse and dependence (F10.-)

Nearest Codes in This Family

Official ICD-10-CM classifications closest to C25.9 in its code family, with their registry titles.

  • C25 — Malignant neoplasm of pancreas
  • C25.0 — Malignant neoplasm of head of pancreas
  • C25.1 — Malignant neoplasm of body of pancreas
  • C25.2 — Malignant neoplasm of tail of pancreas
  • C25.3 — Malignant neoplasm of pancreatic duct
  • C25.4 — Malignant neoplasm of endocrine pancreas
  • C25.7 — Malignant neoplasm of other parts of pancreas
  • C25.8 — Malignant neoplasm of overlapping sites of pancreas

View all codes in the C25 family

Indexed Clinical Terms (2)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Adenocarcinoma, islet cell, with exocrine, mixed, unspecified site
  • Carcinoma (malignant), islet cell, with exocrine, mixed, unspecified site

Neoplasm Table Sites (1)

Anatomical sites from the official ICD-10-CM Table of Neoplasms that map to this code, with the matching behavior column.

  • Neoplasm, neoplastic, pancreas — Malignant, Primary