C25.9 ICD-10-CM Code: Malignant neoplasm of pancreas, unspecified
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Inpatient Payment Groups (MS-DRG)
MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.
- MS-DRG 435 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH MCC (MDC 07)
- MS-DRG 436 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH CC (MDC 07)
- MS-DRG 437 — MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITHOUT CC/MCC (MDC 07)
A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.
Risk Adjustment (CMS-HCC)
Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.
- HCC 20 — Lung and Other Severe Cancers (supersedes HCC 21, HCC 22, HCC 23)
Other models: CMS-HCC V22 HCC 9 · RxHCC V08 HCC 20
Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.
Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.
Official Registry Overview & Definition
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for C25.9 in the official ICD-10-CM tabular list.
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- Kaposi's sarcoma of gastrointestinal sites (C46.4)
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- gastrointestinal stromal tumors (C49.A-)
Code Also
Additional codes that may be required to fully describe the encounter.
- if applicable exocrine pancreatic insufficiency (K86.81)
Use Additional Code
Supplementary codes the tabular list directs you to add.
- Use additional code to identify:
- alcohol abuse and dependence (F10.-)
Nearest Codes in This Family
Official ICD-10-CM classifications closest to C25.9 in its code family, with their registry titles.
- C25 — Malignant neoplasm of pancreas
- C25.0 — Malignant neoplasm of head of pancreas
- C25.1 — Malignant neoplasm of body of pancreas
- C25.2 — Malignant neoplasm of tail of pancreas
- C25.3 — Malignant neoplasm of pancreatic duct
- C25.4 — Malignant neoplasm of endocrine pancreas
- C25.7 — Malignant neoplasm of other parts of pancreas
- C25.8 — Malignant neoplasm of overlapping sites of pancreas
Indexed Clinical Terms (2)
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.
- Adenocarcinoma, islet cell, with exocrine, mixed, unspecified site
- Carcinoma (malignant), islet cell, with exocrine, mixed, unspecified site
Neoplasm Table Sites (1)
Anatomical sites from the official ICD-10-CM Table of Neoplasms that map to this code, with the matching behavior column.
- Neoplasm, neoplastic, pancreas — Malignant, Primary