Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.

MS-DRG 180 — RESPIRATORY NEOPLASMS WITH MCC (MDC 04)
MS-DRG 181 — RESPIRATORY NEOPLASMS WITH CC (MDC 04)
MS-DRG 182 — RESPIRATORY NEOPLASMS WITHOUT CC/MCC (MDC 04)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

HCC 17 — Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic (supersedes HCC 18, HCC 19, HCC 20, HCC 21, HCC 22, HCC 23)

Other models: CMS-HCC V22 HCC 8 · RxHCC V08 HCC 18

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.

Official Registry Overview & Definition

Secondary malignant neoplasm of other respiratory organs is a billable ICD-10-CM diagnosis code (C78.39).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for C78.39 in the official ICD-10-CM tabular list.

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

secondary carcinoid tumors of liver (C7B.02)
secondary carcinoid tumors of peritoneum (C7B.04)

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

lymph node metastases (C77.0)

Nearest Codes in This Family

Official ICD-10-CM classifications closest to C78.39 in its code family, with their registry titles.

C78.2 — Secondary malignant neoplasm of pleura
C78.3 — Secondary malignant neoplasm of other and unspecified respiratory organs
C78.30 — Secondary malignant neoplasm of unspecified respiratory organ
C78.31 — Secondary malignant neoplasm of larynx
C78.32 — Secondary malignant neoplasm of pharynx
C78.4 — Secondary malignant neoplasm of small intestine
C78.5 — Secondary malignant neoplasm of large intestine and rectum
C78.6 — Secondary malignant neoplasm of retroperitoneum and peritoneum
C78.7 — Secondary malignant neoplasm of liver and intrahepatic bile duct
C78.8 — Secondary malignant neoplasm of other and unspecified digestive organs

View all codes in the C78 family

Neoplasm Table Sites (47)

Anatomical sites from the official ICD-10-CM Table of Neoplasms that map to this code, with the matching behavior column.

Neoplasm, neoplastic, antrum (Highmore) (maxillary) — Malignant, Secondary
Neoplasm, neoplastic, antrum (Highmore) (maxillary), tympanicum — Malignant, Secondary
Neoplasm, neoplastic, auditory, canal (external) (skin), internal — Malignant, Secondary
Neoplasm, neoplastic, auditory, tube — Malignant, Secondary
Neoplasm, neoplastic, auricular canal (external), internal — Malignant, Secondary
Neoplasm, neoplastic, cartilage NEC (articular) (joint), bronchi — Malignant, Secondary
Neoplasm, neoplastic, cartilage NEC (articular) (joint), nose, nasal — Malignant, Secondary
Neoplasm, neoplastic, cartilage NEC (articular) (joint), thyroid — Malignant, Secondary
Neoplasm, neoplastic, cartilage NEC (articular) (joint), trachea — Malignant, Secondary
Neoplasm, neoplastic, cavity, nasal — Malignant, Secondary
Neoplasm, neoplastic, cavity, tympanic — Malignant, Secondary
Neoplasm, neoplastic, concha, nose — Malignant, Secondary
Neoplasm, neoplastic, ear (external), inner — Malignant, Secondary
Neoplasm, neoplastic, ear (external), middle — Malignant, Secondary
Neoplasm, neoplastic, ethmoid (sinus) — Malignant, Secondary
Neoplasm, neoplastic, eustachian tube — Malignant, Secondary
Neoplasm, neoplastic, frontal, sinus — Malignant, Secondary
Neoplasm, neoplastic, mastoid (air cells) (antrum) (cavity) — Malignant, Secondary
Neoplasm, neoplastic, maxilla, maxillary (superior), antrum — Malignant, Secondary
Neoplasm, neoplastic, maxilla, maxillary (superior), sinus — Malignant, Secondary
Neoplasm, neoplastic, mucosa, nasal — Malignant, Secondary
Neoplasm, neoplastic, nares, naris (anterior) (posterior) — Malignant, Secondary
Neoplasm, neoplastic, nose, nasal, cartilage — Malignant, Secondary
Neoplasm, neoplastic, nose, nasal, cavity — Malignant, Secondary
Neoplasm, neoplastic, nose, nasal, fossa — Malignant, Secondary
Neoplasm, neoplastic, nose, nasal, internal — Malignant, Secondary
Neoplasm, neoplastic, nose, nasal, mucosa — Malignant, Secondary
Neoplasm, neoplastic, nose, nasal, septum — Malignant, Secondary
Neoplasm, neoplastic, nose, nasal, turbinate (mucosa) — Malignant, Secondary
Neoplasm, neoplastic, nose, nasal, vestibule — Malignant, Secondary
Neoplasm, neoplastic, nostril — Malignant, Secondary
Neoplasm, neoplastic, septum, nasal — Malignant, Secondary
Neoplasm, neoplastic, sinus (accessory) — Malignant, Secondary
Neoplasm, neoplastic, sinus (accessory), ethmoidal — Malignant, Secondary
Neoplasm, neoplastic, sinus (accessory), frontal — Malignant, Secondary
Neoplasm, neoplastic, sinus (accessory), maxillary — Malignant, Secondary
Neoplasm, neoplastic, sinus (accessory), nasal, paranasal NEC — Malignant, Secondary
Neoplasm, neoplastic, sinus (accessory), sphenoid — Malignant, Secondary
Neoplasm, neoplastic, sphenoid — Malignant, Secondary
Neoplasm, neoplastic, sphenoid, sinus — Malignant, Secondary
Neoplasm, neoplastic, thyroid (gland), cartilage — Malignant, Secondary
Neoplasm, neoplastic, trachea (cartilage) (mucosa) — Malignant, Secondary
Neoplasm, neoplastic, tracheobronchial — Malignant, Secondary
Neoplasm, neoplastic, turbinate (bone), nasal — Malignant, Secondary
Neoplasm, neoplastic, tympanic cavity — Malignant, Secondary
Neoplasm, neoplastic, vestibule, nose — Malignant, Secondary
Neoplasm, neoplastic, windpipe — Malignant, Secondary

C78.39 ICD-10-CM Code: Secondary malignant neoplasm of other respiratory organs