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ICD-10/C96.22

C96.22 ICD-10-CM Code: Mast cell sarcoma

C96.22 is the authoritative medical code for Mast cell sarcoma. This classification is used in medical billing and clinical recording to specify the clinical criteria for mast cell sarcoma (ICD-10-CM C96.22), ensuring healthcare documentation aligns with current federal coding standards.

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.

Official Registry Overview & Definition

Mast cell sarcoma is a billable ICD-10-CM diagnosis code (C96.22). Excludes1 (not coded here): indolent mastocytosis (D47.02); mast cell leukemia (C94.30); mastocytosis (congenital) (cutaneous) (Q82.2); personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79). Excludes2 (not included here): Kaposi's sarcoma of lymph nodes (C46.3); secondary and unspecified neoplasm of lymph nodes (C77.-); secondary neoplasm of bone marrow (C79.52); secondary neoplasm of spleen (C78.89).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for C96.22 in the official ICD-10-CM tabular list.

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

  • indolent mastocytosis (D47.02)
  • mast cell leukemia (C94.30)
  • mastocytosis (congenital) (cutaneous) (Q82.2)
  • personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79)

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

  • Kaposi's sarcoma of lymph nodes (C46.3)
  • secondary and unspecified neoplasm of lymph nodes (C77.-)
  • secondary neoplasm of bone marrow (C79.52)
  • secondary neoplasm of spleen (C78.89)

Frequently Asked Questions (FAQ) & Clinical Guidance

What can't be coded together with C96.22?

Per official ICD-10-CM Excludes1 instructions, C96.22 must not be reported together with: indolent mastocytosis (D47.02); mast cell leukemia (C94.30); mastocytosis (congenital) (cutaneous) (Q82.2); personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79).

Can C96.22 be reported alongside related conditions?

Per official ICD-10-CM Excludes2 instructions, C96.22 and the following are not considered part of each other and may both be reported when both conditions are present: Kaposi's sarcoma of lymph nodes (C46.3); secondary and unspecified neoplasm of lymph nodes (C77.-); secondary neoplasm of bone marrow (C79.52); secondary neoplasm of spleen (C78.89).

Nearest Codes in This Family

Official ICD-10-CM classifications closest to C96.22 in its code family, with their registry titles.

  • C96 — Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue
  • C96.0 — Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis
  • C96.2 — Malignant mast cell neoplasm
  • C96.20 — Malignant mast cell neoplasm, unspecified
  • C96.21 — Aggressive systemic mastocytosis
  • C96.29 — Other malignant mast cell neoplasm
  • C96.4 — Sarcoma of dendritic cells (accessory cells)
  • C96.5 — Multifocal and unisystemic Langerhans-cell histiocytosis
  • C96.6 — Unifocal Langerhans-cell histiocytosis
  • C96.9 — Malignant neoplasm of lymphoid, hematopoietic and related tissue, unspecified

View all codes in the C96 family

Indexed Clinical Terms (2)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Mast cell, sarcoma
  • Sarcoma (of), mast cell