D68.59 is the authoritative medical code for Other primary thrombophilia. This classification is used in medical billing and clinical recording to specify the clinical criteria for other primary thrombophilia (ICD-10-CM D68.59), ensuring healthcare documentation aligns with 2026 federal coding standards.
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Official Registry Overview & Definition
Other primary thrombophilia is a billable ICD-10-CM diagnosis code D68.59. Inclusion terms: Antithrombin III deficiency; Hypercoagulable state NOS; Primary hypercoagulable state NEC; Primary thrombophilia NEC; Protein C deficiency; Protein S deficiency; Thrombophilia NOS. Excludes1 (not coded here): antiphospholipid syndrome D68.61; lupus anticoagulant D68.62; secondary activated protein C resistance D68.69; secondary antiphospholipid antibody syndrome D68.69; secondary lupus anticoagulant with hypercoagulable state D68.69; secondary systemic lupus erythematosus SLE inhibitor with hypercoagulable state D68.69; systemic lupus erythematosus SLE inhibitor finding without diagnosis R76.0; systemic lupus erythematosus SLE inhibitor with hemorrhagic disorder D68.312; thrombotic thrombocytopenic purpura M31.19; abnormal coagulation profile NOS R79.1. Excludes2 (not included here): coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1); coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3).
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for D68.59 in the official ICD-10-CM tabular list.
Inclusion Terms
Alternative terms the tabular list files under this code.
- Antithrombin III deficiency
- Hypercoagulable state NOS
- Primary hypercoagulable state NEC
- Primary thrombophilia NEC
- Protein C deficiency
- Protein S deficiency
- Thrombophilia NOS
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- antiphospholipid syndrome D68.61
- lupus anticoagulant D68.62
- secondary activated protein C resistance D68.69
- secondary antiphospholipid antibody syndrome D68.69
- secondary lupus anticoagulant with hypercoagulable state D68.69
- secondary systemic lupus erythematosus SLE inhibitor with hypercoagulable state D68.69
- systemic lupus erythematosus SLE inhibitor finding without diagnosis R76.0
- systemic lupus erythematosus SLE inhibitor with hemorrhagic disorder D68.312
- thrombotic thrombocytopenic purpura M31.19
- abnormal coagulation profile NOS R79.1
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
- coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
Frequently Asked Questions (FAQ) & Clinical Guidance
What can't be coded together with D68.59?
Per Excludes1 instructions, D68.59 must not be reported with: antiphospholipid syndrome (D68.61); lupus anticoagulant (D68.62); secondary activated protein C resistance (D68.69); secondary antiphospholipid antibody syndrome (D68.69).
Can D68.59 be reported alongside related conditions?
Per Excludes2 instructions, D68.59 and the following may both be reported when both are present: coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1); coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3).
What conditions are included under D68.59?
Other primary thrombophilia includes: Antithrombin III deficiency; Hypercoagulable state NOS; Primary hypercoagulable state NEC; Primary thrombophilia NEC; Protein C deficiency.
Codes in This Family (31)
Official ICD-10-CM classifications in the same code family as D68.59, with their registry titles.
- D68 — Other coagulation defects
- D68.0 — Von Willebrand disease
- D68.00 — Von Willebrand disease, unspecified
- D68.01 — Von Willebrand disease, type 1
- D68.02 — Von Willebrand disease, type 2
- D68.020 — Von Willebrand disease, type 2A
- D68.021 — Von Willebrand disease, type 2B
- D68.022 — Von Willebrand disease, type 2M
- D68.023 — Von Willebrand disease, type 2N
- D68.029 — Von Willebrand disease, type 2, unspecified
- D68.03 — Von Willebrand disease, type 3
- D68.04 — Acquired von Willebrand disease
- D68.09 — Other von Willebrand disease
- D68.1 — Hereditary factor XI deficiency
- D68.2 — Hereditary deficiency of other clotting factors
- D68.3 — Hemorrhagic disorder due to circulating anticoagulants
- D68.31 — Hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
- D68.311 — Acquired hemophilia
- D68.312 — Antiphospholipid antibody with hemorrhagic disorder
- D68.318 — Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
- D68.32 — Hemorrhagic disorder due to extrinsic circulating anticoagulants
- D68.4 — Acquired coagulation factor deficiency
- D68.5 — Primary thrombophilia
- D68.51 — Activated protein C resistance
- D68.52 — Prothrombin gene mutation
- D68.6 — Other thrombophilia
- D68.61 — Antiphospholipid syndrome
- D68.62 — Lupus anticoagulant syndrome
- D68.69 — Other thrombophilia
- D68.8 — Other specified coagulation defects
- D68.9 — Coagulation defect, unspecified
Indexed Clinical Terms (11)
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.
- Deficiency, deficient, antithrombin (antithrombin III)
- Deficiency, deficient, protein, C
- Deficiency, deficient, protein, S
- Hypercoagulable (state)
- Hypercoagulable (state), antithrombindeficiency (III)
- Hypercoagulable (state), primary NEC
- Hypercoagulable (state), protein C deficiency
- Hypercoagulable (state), protein S deficiency
- Hypercoagulation (state)
- Thrombophilia
- Thrombophilia, primary NEC
Related Codes & Numerical Sequence (Crawl Map)
Search engines and indexers are advised to traverse adjacent medical codes in this sub-chapter range to find correlated diagnoses or therapeutic procedures: