D68.61 ICD-10-CM Code: Antiphospholipid syndrome
D68.61 is the authoritative medical code for Antiphospholipid syndrome. This classification is used in medical billing and clinical recording to specify the clinical criteria for antiphospholipid syndrome (ICD-10-CM D68.61), ensuring healthcare documentation aligns with current federal coding standards.
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Inpatient Payment Groups (MS-DRG)
MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.
- MS-DRG 814 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITH MCC (MDC 16)
- MS-DRG 815 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITH CC (MDC 16)
- MS-DRG 816 — RETICULOENDOTHELIAL AND IMMUNITY DISORDERS WITHOUT CC/MCC (MDC 16)
A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.
Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.
Official Registry Overview & Definition
Official Tabular Instructional Notes
Sequencing, inclusion, and exclusion notes published for D68.61 in the official ICD-10-CM tabular list.
Inclusion Terms
Alternative terms the tabular list files under this code.
- Anticardiolipin syndrome
- Antiphospholipid antibody syndrome
Excludes1 — Not Coded Here
Conditions that can never be reported with this code; the two are mutually exclusive.
- anti-phospholipid antibody, finding without diagnosis (R76.0)
- diffuse or disseminated intravascular coagulation DIC
- heparin induced thrombocytopenia (HIT) (D75.82-)
- hyperhomocysteinemia (E72.11)
- abnormal coagulation profile NOS (R79.1)
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- anti-phospholipid antibody with hemorrhagic disorder (D68.312)
- lupus anticoagulant syndrome (D68.62)
- coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
- coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
Frequently Asked Questions (FAQ) & Clinical Guidance
What can't be coded together with D68.61?
Per official ICD-10-CM Excludes1 instructions, D68.61 must not be reported together with: anti-phospholipid antibody, finding without diagnosis (R76.0); diffuse or disseminated intravascular coagulation [DIC] (D65); heparin induced thrombocytopenia (HIT) (D75.82-); hyperhomocysteinemia (E72.11).
Can D68.61 be reported alongside related conditions?
Per official ICD-10-CM Excludes2 instructions, D68.61 and the following are not considered part of each other and may both be reported when both conditions are present: anti-phospholipid antibody with hemorrhagic disorder (D68.312); lupus anticoagulant syndrome (D68.62); coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1); coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3).
What conditions are included under D68.61?
Antiphospholipid syndrome includes: Anticardiolipin syndrome; Antiphospholipid antibody syndrome.
Nearest Codes in This Family
Official ICD-10-CM classifications closest to D68.61 in its code family, with their registry titles.
- D68.4 — Acquired coagulation factor deficiency
- D68.5 — Primary thrombophilia
- D68.51 — Activated protein C resistance
- D68.52 — Prothrombin gene mutation
- D68.59 — Other primary thrombophilia
- D68.6 — Other thrombophilia
- D68.62 — Lupus anticoagulant syndrome
- D68.69 — Other thrombophilia
- D68.8 — Other specified coagulation defects
- D68.9 — Coagulation defect, unspecified
Indexed Clinical Terms (9)
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.
- Antibody, anticardiolipin, with, hypercoagulable state
- Antibody, antiphosphatidylglycerol, with, hypercoagulable state
- Antibody, antiphosphatidylinositol, with, hypercoagulable state
- Antibody, antiphosphatidylserine, with, hypercoagulable state
- Antibody, antiphospholipid, with, hypercoagulable state
- Anticardiolipin syndrome
- Antiphospholipid, antibody, syndrome
- Syndrome, anticardiolipin (-antibody)
- Syndrome, antiphospholipid (-antibody)