Prothrombin Time Test and INR (PT/INR)
A prothrombin time (PT) test measures how many seconds it takes for a clot to form in a blood sample.
A prothrombin time (PT) test measures how many seconds it takes for a clot to form in a blood sample. Since the results of this test can vary with different labs or test methods, your results may be used to create an INR (international normalized ratio). Using this ratio makes it easier for health care providers to compare and better understand results from different labs or test methods. Prothrombin is a protein made by the liver. It is one of several substances known as clotting (coagulation) factors. When you get a cut or other injury that causes bleeding, your clotting factors work together to form a blood clot. Blood clotting is an important process that prevents you from losing too much blood when you are injured. Clotting factor levels that are too low can cause you to bleed too much after an injury. Levels that are too high can cause dangerous clots to form in your arteries or veins. A PT/INR test helps find out if your blood is clotting normally. It also checks to see if a medicine that prevents blood clots is working the way it should. Other names: prothrombin time/international normalized ratio, PT, pro time
Why is this test ordered? If you are regularly taking warfarin, you may need this test to make sure you are taking the right dose. Your provider will let you know how often you need to get the test to monitor your dose. If you are not taking warfarin, you may need this test if you have symptoms of a bleeding or clotting disorder. Symptoms of a bleeding disorder include: Unexplained heavy bleeding Bruising easily Unusually heavy nose bleeds Unusually heavy menstrual periods in women Symptoms of a clotting disorder include: Leg pain or tenderness Leg swelling Redness or darkening of the skin on the leg Skin that feels warm Trouble breathing Cough Chest pain Rapid heartbeat and breathing In addition, you may need a PT/INR test if you are scheduled for surgery. It helps make sure your blood is clotting normally, so you won't lose too much blood during the procedure.
Clinical Interpretation
If you were tested because you are taking warfarin or have certain health conditions, your results will probably be in the form of INR levels: INR levels that are too low may mean you are at risk for dangerous blood clots because your blood clots too easily. INR levels that are too high may mean you are at risk for dangerous bleeding because your blood is taking longer than normal to form a clot. If your INR is not normal, your provider will probably change your dose of warfarin. If you are not taking warfarin, your results may be in the form of a PT time, which is the number of seconds it takes for your blood sample to clot (prothrombin time). If you are not taking warfarin and your INR or prothrombin time results are not normal, it may be a sign of that your blood is not clotting normally. If your PT/INR levels are too low , your blood is clotting too quickly. This may be due to: A clotting disorder, a condition in which your body forms too many clots in arteries or veins. Clots can form when you don't have an injury, or they don't dissolve when they should. Supplements with vitamin K, or a diet high in vitamin K. Certain medicines. If your PT/INR levels are too high , your blood is clotting too slowly. This may be due to: A bleeding disorder, a condition in which your body can't clot blood well. When you have an injury or a procedure that may cause bleeding, it may cause too much bleeding. Liver disease. Vitamin K deficiency. Vitamin K plays an important role in blood clotting. Be sure to tell your provider if you are taking any medicines or supplements. Some may affect your results. Other things that may affect your PT/INR results include: Alcohol Foods high in vitamin K, such as green leafy vegetables Soybean and canola oils High-fat diets Ask your provider what you should avoid before your PT/INR test. To understand the results of a PT/INR test, your provider will consider your symptoms, medical history, and the results of other blood tests. Learn more about laboratory tests, reference ranges, and understanding results.
Medicare NCD code list — diagnoses CMS lists as supporting medical necessity
Showing 18 of 7,271 diagnoses CMS lists as covered for this test under NCD 190.17. The complete list is in CMS's Lab NCD code list; a listing is CMS's published code list, not a coverage determination for any claim.
Clinical Protocol & Patient Advice
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If you are taking warfarin, you may need to delay your daily dose until after testing. Your provider will let you know if there are any other special instructions to follow.
Usage Guidance
- Reference ranges vary by laboratory. Always discuss your specific results with a qualified healthcare professional.
Source: MedlinePlus, National Library of Medicine. View the original.
Read from: MedlinePlus (NLM); reference ranges only where NIDDK, NIH ODS or NCI states the value, linked per page — Curated from federal sources. All data sources · How to read the labels
Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources