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D68.312 vs D68.61

D68.312 (Antiphospholipid antibody with hemorrhagic disorder) compared with D68.61 (Antiphospholipid syndrome), from the official CMS tabular data.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 20, 2026 · All releases and sources

Summary

These codes can be reported together when both conditions are documented, because D68.312 lists D68.61 under Excludes2, which marks them as distinct conditions.

Official rule
What is different?

The conditions named.D68.312 is “Antiphospholipid antibody with hemorrhagic disorder”; D68.61 is “Antiphospholipid syndrome”.

Registry fact

Can these codes be reported together?

Yes, when both are documented.D68.312 lists D68.61 under Excludes2: “antiphospholipid antibody syndrome (D68.61)”. Excludes2 marks distinct conditions that may both be reported when both are documented.

Official ruleGuide: Excludes1 vs Excludes2

Is there an Excludes1 relationship?

None.Neither entry carries an Excludes1 note that names the other code. D68.312 carries 4 Excludes1 notes and D68.61 carries 5 Excludes1 notes covering other codes; the side-by-side table quotes them.

Official rule

Is there an Excludes2 relationship?

Yes.D68.312’s tabular entry: “antiphospholipid antibody syndrome (D68.61)”. The note covers D68.61.

Official ruleGuide: Excludes1 vs Excludes2

Is one more specific?

No.Neither is a subdivision of the other, and neither title is the unspecified form; they describe different conditions within category D68.

Registry fact

Is one a parent or header code?

No.Both are billable codes, and neither contains the other.

Registry fact

Are there sequencing instructions?

None.Neither entry carries a Code First or Use Additional Code note that names the other.

Official rule

Are there other coding relationships?

None found.No laterality, encounter-phase, Table of Neoplasms, Table of Drugs and Chemicals, or history-versus-active-disease relationship links these codes.

MedCoder-derived

Official rule: a tabular instructional note or a section of the ICD-10-CM Official Guidelines, quoted as published. Registry fact: the codes’ own published attributes (titles, billable status, position in the hierarchy, code set). MedCoder-derived: a reading MedCoder computes from those facts; it is not itself a rule. How to read the labels

Can these codes be reported together?

Informational

Excludes2 relationship

D68.312
Antiphospholipid antibody with hemorrhagic disorder
↔
D68.61
Antiphospholipid syndrome

What we found

Yes, when both are documented.D68.312 carries an Excludes2 note covering D68.61: “antiphospholipid antibody syndrome (D68.61)”

Excludes2 marks distinct conditions — both may be reported when both are documented.

What to review

Report both only when the documentation supports both conditions; otherwise report the one documented.

Guide: Excludes1 vs Excludes2Check these on a claim

Why it matters

An Excludes2 note means the excluded condition is not part of the code above it, but a patient can have both. Report both when both are documented.

Source / rule

CMS ICD-10-CM tabular instructional notes

Official guidance behind these answers

  • Section I.A.12.b — Excludes2 · applies to: Excludes2

    A type 2 Excludes note represents “Not included here.” An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.

    ICD-10-CM Official Guidelines FY2027

Quoted from the ICD-10-CM Official Guidelines for Coding and Reporting in effect for the release shown. The tabular notes above are the code-level instruction; these sections are the convention that says how such a note is applied. Source document (CMS PDF) · Release and checksum

Side by side

D68.312Antiphospholipid antibody with hemorrhagic disorderD68.61Antiphospholipid syndrome
Billing statusBillableBillable
ClassificationD50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89)D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89)
DefinitionAntiphospholipid antibody with hemorrhagic disorder is a billable ICD-10-CM diagnosis code (D68.312).Antiphospholipid syndrome is a billable ICD-10-CM diagnosis code (D68.61).
Includes
Lupus anticoagulant (LAC) with hemorrhagic disorder
Systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder
Anticardiolipin syndrome
Antiphospholipid antibody syndrome
Excludes1
antiphospholipid antibody, finding without diagnosis (R76.0)
lupus anticoagulant (LAC) finding without diagnosis (R76.0)
systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
abnormal coagulation profile NOS (R79.1)
anti-phospholipid antibody, finding without diagnosis (R76.0)
diffuse or disseminated intravascular coagulation [DIC] (D65)
heparin induced thrombocytopenia (HIT) (D75.82-)
hyperhomocysteinemia (E72.11)
abnormal coagulation profile NOS (R79.1)
Excludes2
antiphospholipid antibody syndrome (D68.61)
antiphospholipid antibody with hypercoagulable state (D68.61)
lupus anticoagulant (LAC) with hypercoagulable state (D68.62)
systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.62)
coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)
anti-phospholipid antibody with hemorrhagic disorder (D68.312)
lupus anticoagulant syndrome (D68.62)
coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)

Notes are the code’s own tabular entry, quoted as published. A note that names the other code is the one the verdict above rests on.

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Derived from the official CMS ICD-10-CM tabular data (FY2027). A coding-rule comparison, not billing advice: payer-specific edits and medical-necessity policy are outside its scope. All data sources