D75.81 ICD-10-CM Code: Myelofibrosis
Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.
Coding at a Glance
Inpatient Payment Groups (MS-DRG)
Potential MS-DRG participation — not a DRG assignment.
MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.
- MS-DRG 820 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH MCC (MDC 17)
- MS-DRG 821 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH CC (MDC 17)
- MS-DRG 822 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITHOUT CC/MCC (MDC 17)
- MS-DRG 823 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITH MCC (MDC 17)
- MS-DRG 824 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITH CC (MDC 17)
- MS-DRG 825 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITHOUT CC/MCC (MDC 17)
- MS-DRG 840 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH MCC (MDC 17)
- MS-DRG 841 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH CC (MDC 17)
- MS-DRG 842 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITHOUT CC/MCC (MDC 17)
A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.
Risk Adjustment (CMS-HCC)
Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.
- HCC 19 — Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers (supersedes HCC 20, HCC 21, HCC 22, HCC 23)
Other models: CMS-HCC V22 HCC 46 · RxHCC V08 HCC 16
Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.
Coding instructions
Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for D75.81 in the official ICD-10-CM tabular list, quoted as published.
Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025
Notes without a marker are published on D75.81 itself; “inherited from” names the category or block whose note applies here.
Inclusion Terms
Alternative terms the tabular list files under this code.
- Myelofibrosis NOS
- Secondary myelofibrosis NOS
Excludes1 — Not Coded Here
Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
- acute myelofibrosis (C94.4-) Compare D75.81 vs C94.4 →
- idiopathic myelofibrosis (D47.1) Compare D75.81 vs D47.1 →
- leukoerythroblastic anemia (D61.82) Compare D75.81 vs D61.82 →
- myelofibrosis with myeloid metaplasia (D47.4) Compare D75.81 vs D47.4 →
- myelophthisic anemia (D61.82) Compare D75.81 vs D61.82 →
- myelophthisis (D61.82) Compare D75.81 vs D61.82 →
- primary myelofibrosis (D47.1) Compare D75.81 vs D47.1 →
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- acute lymphadenitis (L04.-) Compare D75.81 vs L04 →
- chronic lymphadenitis (I88.1) Compare D75.81 vs I88.1 →
- enlarged lymph nodes (R59.-) Compare D75.81 vs R59 →
- hypergammaglobulinemia NOS (D89.2) Compare D75.81 vs D89.2 →
- lymphadenitis NOS (I88.9) Compare D75.81 vs I88.9 →
- mesenteric lymphadenitis (acute) (chronic) (I88.0) Compare D75.81 vs I88.0 →
Source: inherited from D75
Code First
Underlying conditions that must be sequenced before this code.
- the underlying disorder, such as:
- malignant neoplasm of breast (C50.-)
Coder workflow for D75.81
MedCoder structured workflow — derived from this code’s own official record
Before you code D75.81
- Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with D75.81. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).
Choose the right path
- Does the documentation support a condition named in D75.81’s Excludes1 note?
Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
No → Continue. - Is the underlying (etiologic) condition the Code First note names documented?
Yes → Sequence the underlying condition first, then D75.81.
No → Continue; do not add an underlying condition the record does not document.ReviewC50
Consider D75.81. Then work the Use Additional Code note, and confirm the code is valid for the date of service in the Verify section.
Documentation check
- The provider’s diagnostic statement
- Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
- The underlying (etiologic) condition
- Named in the Code First note; sequenced before this code when documented (Guidelines I.A.13).
- The conditions the Use Additional Code note names
- Reported with this code when documented; a conditional instruction (“if applicable”, “if known”) applies only when the record supports it.
Official instructions as workflow
Excludes1 — check before selecting D75.81(7 notes)
Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with D75.81: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.
CompareC94.4, D47.1, D61.82, D47.4
See the official tabular notes · Guidelines I.A.12.a
Excludes2 — not part of D75.81(6 notes)
Coding workflow: The conditions named in this note are not included in D75.81. When the record documents both, both may be reported; the note is a boundary, not a prohibition.
CompareL04, I88.1, R59, D89.2, I88.9, I88.0
See the official tabular notes · Guidelines I.A.12.b
Code First — sequencing check(2 notes)
Coding workflow: Check whether the underlying or etiologic condition the note names is documented. When it is, sequence it before D75.81. Do not add an underlying condition the record does not document.
ReviewC50
See the official tabular notes · Guidelines I.A.13
Use Additional Code — after identifying D75.81(2 notes)
Coding workflow: Check whether the documentation supports the additional code(s) the note names, and report them with D75.81 when it does. Where the instruction is conditional (“if applicable”, “if known”), it applies only when the record documents the condition.
See the official tabular notes · Guidelines I.A.13
Coding decision scenarios
Pattern scenarios for this code’s structure — decision rules, not clinical cases
Documentation: Both the condition D75.81 describes and a condition named in its Excludes1 note are documented for the same encounter.
Coding question: Can both codes be reported?
Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.
Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).
Documentation: The underlying condition the Code First note names is documented alongside this condition.
Coding question: How are the two sequenced?
Path: Review the Code First note.
Reason: The underlying condition is sequenced first and the manifestation follows (Guidelines I.A.13).
ReviewC50
Documentation: A condition the Use Additional Code note names is documented.
Coding question: Is a second code reported with D75.81?
Path: Review the Use Additional Code note and the code it names.
Reason: The additional code is reported when the record documents the condition; a conditional instruction applies only when its condition is met (Guidelines I.A.13).
Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.
Code Overview
MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.
Indexed Clinical Terms (4)
Official source data — entries quoted as published, in the Index’s own lookup phrasing
Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.
Official Coding Guidelines
No excerpt in the ICD-10-CM Official Guidelines names this code specifically. Its chapter carries only this chapter-wide note:
Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)
Reserved for future guideline expansion
Decision Points
The directives on this code's own record, as a pre-claim checklist.
- Sequencing: 2 Code First instructions — the underlying condition is sequenced before this code when present. See the Code First notes
- 2 Use Additional Code instructions — report the named additional code(s) when the documentation supports them. See the Use Additional Code notes
- 7 Excludes1 entries — codes named there are generally not reported together with this code (Guidelines I.A.12.a). See the Excludes1 notes
- 6 Excludes2 entries — those conditions are not part of this code and may be reported additionally when documented. See the Excludes2 notes
Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.
Verify Before Coding
- Principal-diagnosis restriction. This is a manifestation code: the Medicare Code Editor requires the underlying condition (etiology) to be sequenced first, with this code reported after it.
- CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.
From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.
Relationships & Classification
MedCoder structured relationships — computed from published CMS and AHRQ datasets
Other codes that name D75.81 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.
Referenced by 4 Excludes1 notes across 3 chapters: C94.4 — Acute panmyelosis with myelofibrosis, D47.1 — Chronic myeloproliferative disease, D61.82 — Myelophthisis, M85.8 — Other specified disorders of bone density and structure.
These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.
Referenced by 21 Code First instructions: T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics (via D75.-), T36-T39 — Antibiotics & Anti-infectives (T36-T39) (via D75.-), T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50) (via D75.-), T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics (via D75.-), T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (via D75.-), T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (via D75.-), T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens] (via D75.-), T40-T41 — Analgesics & Antipyretics (T40-T41) (via D75.-), T41 — Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases (via D75.-), T42 — Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (via D75.-), T42-T43 — Anticonvulsants & Psychotropics (T42-T43) (via D75.-), T43 — Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified (via D75.-), T44 — Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (via D75.-), T44-T46 — Cardiovascular & Gastrointestinal (T44-T46) (via D75.-), T45 — Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (via D75.-), T46 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (via D75.-), T47 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system (via D75.-), T47-T50 — Hormones & Systemic Agents (T47-T50) (via D75.-), T48 — Poisoning by, adverse effect of and underdosing of agents primarily acting on smooth and skeletal muscles and the respiratory system (via D75.-), T49 — Poisoning by, adverse effect of and underdosing of topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinorlaryngological and dental drugs (via D75.-), +1 more.
Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.
MS-DRG Grouper Relationships (FY2026)
Potential MS-DRG participation — not a DRG assignment.
FY2026 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 133 clinically related codes on its CMS exclusion list.
Named in the grouper logic of 9 MS-DRGs: DRG 820 (MDC 17), DRG 821 (MDC 17), DRG 822 (MDC 17), DRG 823 (MDC 17), DRG 824 (MDC 17), DRG 825 (MDC 17), DRG 840 (MDC 17), DRG 841 (MDC 17), DRG 842 (MDC 17).
From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.
Clinical classification (AHRQ CCSR):BLD010 — Other specified and unspecified hematologic conditions.
Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.
Related Codes
Same clinical process (MS-DRG)
Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.
D46.1 — Refractory anemia with ring sideroblasts, D46.20 — Refractory anemia with excess of blasts, unspecified, D46.21 — Refractory anemia with excess of blasts 1, D46.22 — Refractory anemia with excess of blasts 2, D46.4 — Refractory anemia, unspecified, D46.9 — Myelodysplastic syndrome, unspecified, D46.A — Refractory cytopenia with multilineage dysplasia, D46.B — Refractory cytopenia with multilineage dysplasia and ring sideroblasts, D46.C — Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality, D46.Z — Other myelodysplastic syndromes, D47.01 — Cutaneous mastocytosis, D47.02 — Systemic mastocytosis, D47.09 — Other mast cell neoplasms of uncertain behavior, D47.1 — Chronic myeloproliferative disease, D47.3 — Essential (hemorrhagic) thrombocythemia, D47.9 — Neoplasm of uncertain behavior of lymphoid, hematopoietic and related tissue, unspecified, D47.Z2 — Castleman disease, D47.Z9 — Other specified neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue, D48.7 — Neoplasm of uncertain behavior of other specified sites, D48.9 — Neoplasm of uncertain behavior, unspecified, +113 more
Principal diagnosis restriction (Medicare Code Editor)
Manifestation code — the underlying condition is sequenced first.
Same CMS-HCC risk category (V28)
CMS maps these diagnoses to the same Hierarchical Condition Category (Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers) for risk-adjusted payment.
C91.31 — Prolymphocytic leukemia of B-cell type, in remission, C91.32 — Prolymphocytic leukemia of B-cell type, in relapse, C91.50 — Adult T-cell lymphoma/leukemia (HTLV-1-associated) not having achieved remission, C91.51 — Adult T-cell lymphoma/leukemia (HTLV-1-associated), in remission, C91.52 — Adult T-cell lymphoma/leukemia (HTLV-1-associated), in relapse, C91.60 — Prolymphocytic leukemia of T-cell type not having achieved remission, C91.61 — Prolymphocytic leukemia of T-cell type, in remission, C91.62 — Prolymphocytic leukemia of T-cell type, in relapse, C94.6 — Myelodysplastic disease, not elsewhere classified, D46.0 — Refractory anemia without ring sideroblasts, so stated, D46.1 — Refractory anemia with ring sideroblasts, D46.20 — Refractory anemia with excess of blasts, unspecified, D46.21 — Refractory anemia with excess of blasts 1, D46.4 — Refractory anemia, unspecified, D46.9 — Myelodysplastic syndrome, unspecified, D46.A — Refractory cytopenia with multilineage dysplasia, D46.B — Refractory cytopenia with multilineage dysplasia and ring sideroblasts, D46.C — Myelodysplastic syndrome with isolated del(5q) chromosomal abnormality, D46.Z — Other myelodysplastic syndromes, D47.4 — Osteomyelofibrosis, +47 more
Related risk categories
These categories interact through CMS's HCC hierarchy — one can suppress the other's risk-adjustment weight when both are present on a claim.
Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic, Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid, Lung and Other Severe Cancers, Lymphoma and Other Cancers, Bladder, Colorectal, and Other Cancers, Prostate, Breast, and Other Cancers and Tumors
Same clinical category (CCSR)
AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other specified and unspecified hematologic conditions).
A18.85 — Tuberculosis of spleen, B51.0 — Plasmodium vivax malaria with rupture of spleen, D73.0 — Hyposplenism, D73.1 — Hypersplenism, D73.2 — Chronic congestive splenomegaly, D73.3 — Abscess of spleen, D73.4 — Cyst of spleen, D73.5 — Infarction of spleen, D73.89 — Other diseases of spleen, D73.9 — Disease of spleen, unspecified, D74.0 — Congenital methemoglobinemia, D74.8 — Other methemoglobinemias, D74.9 — Methemoglobinemia, unspecified, D75.0 — Familial erythrocytosis, D75.1 — Secondary polycythemia, D75.89 — Other specified diseases of blood and blood-forming organs, D75.9 — Disease of blood and blood-forming organs, unspecified, D75.A — Glucose-6-phosphate dehydrogenase (G6PD) deficiency without anemia, D77 — Other disorders of blood and blood-forming organs in diseases classified elsewhere, M36.3 — Arthropathy in other blood disorders
Same Index main term, other category
The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Anemia”, “Osteosclerosis”; these codes share that main term but sit in a different category of the Tabular List.
D63.1 — Anemia in chronic kidney disease (in, failure, kidney), D63.8 — Anemia in other chronic diseases classified elsewhere (intertropical), D64.0 — Hereditary sideroblastic anemia (sideroblastic, hereditary), D64.1 — Secondary sideroblastic anemia due to disease (sideroblastic, secondary, disease), D64.2 — Secondary sideroblastic anemia due to drugs and toxins (sideroblastic, secondary, drugs and toxins), D64.3 — Other sideroblastic anemias (sideroblastic), D64.4 — Congenital dyserythropoietic anemia (dyshematopoietic), D64.81 — Anemia due to antineoplastic chemotherapy (due to, antineoplastic chemotherapy), D64.89 — Other specified anemias (splenic), D64.9 — Anemia, unspecified, E03.9 — Hypothyroidism, unspecified (due to, myxedema), I67.89 — Other cerebrovascular disease (cerebral), M85.8 — Other specified disorders of bone density and structure (acquired), O90.81 — Anemia of the puerperium (postpartum), P55.0 — Rh isoimmunization of newborn (newborn, due to, Rh), P55.1 — ABO isoimmunization of newborn (newborn, due to, ABO), P55.9 — Hemolytic disease of newborn, unspecified (erythroblastic, newborn), P61.2 — Anemia of prematurity (of prematurity), P61.3 — Congenital anemia from fetal blood loss (newborn, posthemorrhagic), P61.4 — Other congenital anemias, not elsewhere classified (newborn), +80 more
Contextual Map
Every relationship of D75.81 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.
Run D75.81 with these 16 related codes in Claim Check
Hierarchy
- D50-D89 — Chapter 3: Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) (D50-D89)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
Excludes1
- C94.4 — Acute panmyelosis with myelofibrosis[Excludes1]: “acute myelofibrosis (C94.4-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- D47.1 — Chronic myeloproliferative disease[Excludes1]: “idiopathic myelofibrosis (D47.1)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- D47.4 — Osteomyelofibrosis[Excludes1]: “myelofibrosis with myeloid metaplasia (D47.4)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- D61.82 — Myelophthisis[Excludes1]: “leukoerythroblastic anemia (D61.82)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Code First
- C50 — Malignant neoplasm of breast[Code First]: “malignant neoplasm of breast (C50.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Use Additional Code
- D46 — Myelodysplastic syndromes[Use Additional Code]: “code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T45.1X5 — Adverse effect of antineoplastic and immunosuppressive drugs[Use Additional Code]: “code for adverse effect, if applicable, to identify drug (T45.1X5)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Referenced by Excludes1 notes
- C94.4 — Acute panmyelosis with myelofibrosis[Excludes1]: “myelofibrosis NOS (D75.81)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- D47.1 — Chronic myeloproliferative disease[Excludes1]: “myelofibrosis NOS (D75.81)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- D61.82 — Myelophthisis[Excludes1]: “myelofibrosis NOS (D75.81)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- M85.8 — Other specified disorders of bone density and structure[Excludes1]: “osteosclerosis myelofibrosis (D75.81)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Referenced by Code First instructions (21)
- T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T36-T39 — Antibiotics & Anti-infectives (T36-T39)[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50)[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens][Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- T40-T41 — Analgesics & Antipyretics (T40-T41)[Code First](via D75.-): “blood disorders (D56-D76)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- and 13 more
Clinical classification (CCSR)
- BLD010 — Other specified and unspecified hematologic conditions[CCSR]— AHRQ CCSR for ICD-10-CM Diagnoses (HCUP)
Risk adjustment (CMS-HCC)
- HCC 19 — Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers [CMS-HCC]: “Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers — supersedes HCC 20 (Lung and Other Severe Cancers), HCC 21 (Lymphoma and Other Cancers), HCC 22 (Bladder, Colorectal, and Other Cancers), HCC 23 (Prostate, Breast, and Other Cancers and Tumors)”— CMS-HCC V28 · 2026
MS-DRG Grouper (9)
- CC — Complication or Comorbidity [MS-DRG severity]: “As a secondary diagnosis this code can raise the stay's MS-DRG severity tier (CC).”— CMS MS-DRG Definitions Manual (Appendix C) · FY2026
- DRG 820 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH MCC[MS-DRG]: “LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH MCC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
- DRG 821 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH CC[MS-DRG]: “LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH CC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
- DRG 822 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITHOUT CC/MCC[MS-DRG]: “LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITHOUT CC/MCC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
- DRG 823 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITH MCC[MS-DRG]: “LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITH MCC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
- DRG 824 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITH CC[MS-DRG]: “LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITH CC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
- DRG 825 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITHOUT CC/MCC[MS-DRG]: “LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITHOUT CC/MCC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
- DRG 840 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH MCC[MS-DRG]: “LYMPHOMA AND NON-ACUTE LEUKEMIA WITH MCC (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
- and 2 more
MDC crossing
- MDC 17 — Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms[MDC crossing]: “Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 4,730 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026
Index entries
- Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), myelofibrosis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
- Myelofibrosis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
- Myelofibrosis, secondary[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
- Osteosclerosis, myelofibrosis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
Nearest codes (16)
- D75 — Other and unspecified diseases of blood and blood-forming organs[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- D75.0 — Familial erythrocytosis[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- D75.1 — Secondary polycythemia[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- D75.8 — Other specified diseases of blood and blood-forming organs[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- D75.82 — Heparin induced thrombocytopenia (HIT)[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- D75.821 — Non-immune heparin-induced thrombocytopenia[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- D75.822 — Immune-mediated heparin-induced thrombocytopenia[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- D75.828 — Other heparin-induced thrombocytopenia syndrome[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- and 8 more
Change history
- FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016
Sources for this page
Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.
- Code, title, tabular notes and index terms Official source data
- CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
- Coding guidelines Official source data
- ICD-10-CM Official Guidelines for Coding and Reporting (FY2026), quoted by section Release, file and checksum · Publisher’s page
- Claim edits Official source data
- CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
- Inpatient payment groups Official source data
- CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
- Risk adjustment Official source data
- 2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page
- Change history and date-of-service validity Official source data
- CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
- Comparisons, relationships and the contextual map MedCoder structured relationship
- Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
- Summary and FAQ answers MedCoder explanation
- Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.
Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates
Cite this page
Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.
MedCoder.ai. "D75.81 — Myelofibrosis." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/d75.81-myelofibrosis
Change history
- FY2016 — October 1, 2015In the code set at ICD-10-CM adoptionMyelofibrosis
No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.
Nearest Codes in This Family
Official ICD-10-CM classifications closest to D75.81 in its code family, with their registry titles.
- D75 — Other and unspecified diseases of blood and blood-forming organs
- D75.0 — Familial erythrocytosis
- D75.1 — Secondary polycythemia
- D75.8 — Other specified diseases of blood and blood-forming organs
- D75.82 — Heparin induced thrombocytopenia (HIT)
- D75.821 — Non-immune heparin-induced thrombocytopenia
- D75.822 — Immune-mediated heparin-induced thrombocytopenia
- D75.828 — Other heparin-induced thrombocytopenia syndrome
- D75.829 — Heparin-induced thrombocytopenia, unspecified
- D75.83 — Thrombocytosis