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E10.43 ICD-10-CM Code: Type 1 diabetes mellitus with diabetic autonomic (poly)neuropathy

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 008 — SIMULTANEOUS PANCREAS AND KIDNEY TRANSPLANT (MDC PRE)
  • MS-DRG 010 — PANCREAS TRANSPLANT (MDC PRE)
  • MS-DRG 019 — SIMULTANEOUS PANCREAS AND KIDNEY TRANSPLANT WITH HEMODIALYSIS (MDC PRE)
  • MS-DRG 073 — CRANIAL AND PERIPHERAL NERVE DISORDERS WITH MCC (MDC 01)
  • MS-DRG 074 — CRANIAL AND PERIPHERAL NERVE DISORDERS WITHOUT MCC (MDC 01)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 37 — Diabetes with Chronic Complications (supersedes HCC 38)

Other models: CMS-HCC V22 HCC 18 · RxHCC V08 HCC 30

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for E10.43 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on E10.43 itself; “inherited from” names the category or block whose note applies here.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • brittle diabetes (mellitus)
  • diabetes (mellitus) due to autoimmune process
  • diabetes (mellitus) due to immune mediated pancreatic islet beta-cell destruction
  • idiopathic diabetes (mellitus)
  • juvenile onset diabetes (mellitus)
  • ketosis-prone diabetes (mellitus)

Source: inherited from E10

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Type 1 diabetes mellitus with diabetic gastroparesis

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Source: inherited from E10

Coder workflow for E10.43

MedCoder structured workflow — derived from this code’s own official record

Before you code E10.43

  1. E10.43’s title joins a condition with an associated condition or complication. Confirm each component is documented. Where the classification presumes the link through the “with” convention, only a provider statement that the conditions are unrelated defeats it. A combination code is assigned only when it fully identifies the documented conditions; a required second code for the stage, type or manifestation is still reported when the notes ask for it (Guidelines I.B.9, I.A.15).

    Guide: Combination codes →

  2. Confirm the documented diabetes type or cause (the E08–E13 categories are separated by it) and every documented complication or manifestation; the code is built from the type first and the complication second. Then work the category’s Use Additional Code notes for medication and control status. Type 2 is the default only when the type is not documented, and insulin or other medication use does not by itself establish the type (Guidelines I.C.4.a.2, I.C.4.a.3).

    Guide: Diabetes with multiple complications →

  3. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with E10.43. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in E10.43’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewE08, E09, O24.4, R73.9, P70.2, E13

Consider E10.43. Then confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
The associated condition or complication
Whether the associated condition the title names is documented; the “with” convention presumes some links, and a provider statement that the conditions are unrelated defeats it (Guidelines I.A.15).
Diabetes type or cause, each complication, and medication use
The type is documented, not inferred from medication (Guidelines I.C.4.a.3); each documented complication takes its own combination code.

Official instructions as workflow

  • Excludes1 — check before selecting E10.43(9 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with E10.43: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareE08, E09, O24.4, R73.9, P70.2, E13

    See the official tabular notes · Guidelines I.A.12.a

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition E10.43 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewE08, E09, O24.4, R73.9, P70.2, E13

Documentation: Only one of the components this code’s title joins is documented.

Coding question: Is E10.43 supported?

Path: Review the code for the documented component on its own.

Reason: A combination code is assigned only when it fully identifies the documented conditions; otherwise the documented component takes its own code (Guidelines I.B.9).

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Type 1 diabetes mellitus with diabetic autonomic (poly)neuropathy is a billable ICD-10-CM diagnosis code (E10.43).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (3)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name E10.43 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 24 Excludes1 notes across 9 chapters: E08 — Diabetes mellitus due to underlying condition (via E10.-), E09 — Drug or chemical induced diabetes mellitus (via E10.-), E11 — Type 2 diabetes mellitus (via E10.-), E13 — Other specified diabetes mellitus (via E10.-), E74 — Other disorders of carbohydrate metabolism (via E10.-), E87.2 — Acidosis (via E10.-), G54.5 — Neuralgic amyotrophy (via E10.-), G59 — Mononeuropathy in diseases classified elsewhere (via E10.-), G63 — Polyneuropathy in diseases classified elsewhere (via E10.-), G99.0 — Autonomic neuropathy in diseases classified elsewhere (via E10.-), H20.0 — Acute and subacute iridocyclitis (via E10.-), I73.8 — Other specified peripheral vascular diseases (via E10.-), I79.8 — Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere (via E10.-), L92.1 — Necrobiosis lipoidica, not elsewhere classified (via E10.-), L99 — Other disorders of skin and subcutaneous tissue in diseases classified elsewhere (via E10.-), M14 — Arthropathies in other diseases classified elsewhere (via E10.-), M14.6 — Charcôt's joint (via E10.-), M90 — Osteopathies in diseases classified elsewhere (via E10.-), N08 — Glomerular disorders in diseases classified elsewhere (via E10.-), N16 — Renal tubulo-interstitial disorders in diseases classified elsewhere (via E10.-), +4 more.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 3 Excludes2 notes across 3 chapters: H35 — Other retinal disorders (via E10.-), I96 — Gangrene, not elsewhere classified (via E10.-), K31 — Other diseases of stomach and duodenum.

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

Referenced by 2 Code First instructions across 2 chapters: D84.81 — Immunodeficiency due to conditions classified elsewhere (via E10.-), K31.84 — Gastroparesis.

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Referenced by 1 Code Also instruction: N76.82 — Fournier disease of vagina and vulva (via E10.-).

These codes suggest coding this condition alongside when both are present.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 5 MS-DRGs: DRG 008 (MDC PRE), DRG 010 (MDC PRE), DRG 019 (MDC PRE), DRG 073 (MDC 01), DRG 074 (MDC 01).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):END003 — Diabetes mellitus with complication (default); END004 — Diabetes mellitus, Type 1; NVS015 — Polyneuropathies.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Diabetes with Chronic Complications) for risk-adjusted payment.

E10.3599 — Type 1 diabetes mellitus with proliferative diabetic retinopathy without macular edema, unspecified eye, E10.36 — Type 1 diabetes mellitus with diabetic cataract, E10.37X1 — Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment, right eye, E10.37X2 — Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment, left eye, E10.37X3 — Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment, bilateral, E10.37X9 — Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment, unspecified eye, E10.39 — Type 1 diabetes mellitus with other diabetic ophthalmic complication, E10.40 — Type 1 diabetes mellitus with diabetic neuropathy, unspecified, E10.41 — Type 1 diabetes mellitus with diabetic mononeuropathy, E10.42 — Type 1 diabetes mellitus with diabetic polyneuropathy, E10.44 — Type 1 diabetes mellitus with diabetic amyotrophy, E10.49 — Type 1 diabetes mellitus with other diabetic neurological complication, E10.51 — Type 1 diabetes mellitus with diabetic peripheral angiopathy without gangrene, E10.52 — Type 1 diabetes mellitus with diabetic peripheral angiopathy with gangrene, E10.59 — Type 1 diabetes mellitus with other circulatory complications, E10.610 — Type 1 diabetes mellitus with diabetic neuropathic arthropathy, E10.618 — Type 1 diabetes mellitus with other diabetic arthropathy, E10.620 — Type 1 diabetes mellitus with diabetic dermatitis, E10.621 — Type 1 diabetes mellitus with foot ulcer, E10.622 — Type 1 diabetes mellitus with other skin ulcer, +287 more

Related risk categories

These categories interact through CMS's HCC hierarchy — one can suppress the other's risk-adjustment weight when both are present on a claim.

Pancreas Transplant Status, Diabetes with Severe Acute Complications, Diabetes with Glycemic, Unspecified, or No Complications

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical categories (Diabetes mellitus with complication, Diabetes mellitus, Type 1, Polyneuropathies).

E10.3599 — Type 1 diabetes mellitus with proliferative diabetic retinopathy without macular edema, unspecified eye, E10.36 — Type 1 diabetes mellitus with diabetic cataract, E10.37X1 — Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment, right eye, E10.37X2 — Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment, left eye, E10.37X3 — Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment, bilateral, E10.37X9 — Type 1 diabetes mellitus with diabetic macular edema, resolved following treatment, unspecified eye, E10.39 — Type 1 diabetes mellitus with other diabetic ophthalmic complication, E10.40 — Type 1 diabetes mellitus with diabetic neuropathy, unspecified, E10.41 — Type 1 diabetes mellitus with diabetic mononeuropathy, E10.42 — Type 1 diabetes mellitus with diabetic polyneuropathy, E10.44 — Type 1 diabetes mellitus with diabetic amyotrophy, E10.49 — Type 1 diabetes mellitus with other diabetic neurological complication, E10.51 — Type 1 diabetes mellitus with diabetic peripheral angiopathy without gangrene, E10.52 — Type 1 diabetes mellitus with diabetic peripheral angiopathy with gangrene, E10.59 — Type 1 diabetes mellitus with other circulatory complications, E10.610 — Type 1 diabetes mellitus with diabetic neuropathic arthropathy, E10.618 — Type 1 diabetes mellitus with other diabetic arthropathy, E10.620 — Type 1 diabetes mellitus with diabetic dermatitis, E10.621 — Type 1 diabetes mellitus with foot ulcer, E10.622 — Type 1 diabetes mellitus with other skin ulcer, +505 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Diabetes, diabetic”; these codes share that main term but sit in a different category of the Tabular List.

E09.622 — Drug or chemical induced diabetes mellitus with other skin ulcer (due to drug or chemical, with, skin ulcer NEC), E09.628 — Drug or chemical induced diabetes mellitus with other skin complications (due to drug or chemical, with, skin complication NEC), E09.630 — Drug or chemical induced diabetes mellitus with periodontal disease (due to drug or chemical, with, periodontal disease), E09.638 — Drug or chemical induced diabetes mellitus with other oral complications (due to drug or chemical, with, oral complication NEC), E09.641 — Drug or chemical induced diabetes mellitus with hypoglycemia with coma (due to drug or chemical, with, hypoglycemia, with coma), E09.649 — Drug or chemical induced diabetes mellitus with hypoglycemia without coma (due to drug or chemical, with, hypoglycemia), E09.65 — Drug or chemical induced diabetes mellitus with hyperglycemia (due to drug or chemical, with, hyperglycemia), E09.69 — Drug or chemical induced diabetes mellitus with other specified complication (due to drug or chemical, with, complication, specified NEC), E09.8 — Drug or chemical induced diabetes mellitus with unspecified complications (due to drug or chemical, with, complication), E09.9 — Drug or chemical induced diabetes mellitus without complications (due to drug or chemical), E11.00 — Type 2 diabetes mellitus with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC) (with, hyperosmolarity), E11.01 — Type 2 diabetes mellitus with hyperosmolarity with coma (with, hyperosmolarity, with coma), E11.1 — Type 2 diabetes mellitus with ketoacidosis (type 2, with, coma due to, ketoacidosis), E11.10 — Type 2 diabetes mellitus with ketoacidosis without coma (with, ketoacidosis), E11.11 — Type 2 diabetes mellitus with ketoacidosis with coma (with, ketoacidosis, with coma), E11.21 — Type 2 diabetes mellitus with diabetic nephropathy (with, nephropathy), E11.22 — Type 2 diabetes mellitus with diabetic chronic kidney disease (with, chronic kidney disease), E11.29 — Type 2 diabetes mellitus with other diabetic kidney complication (with, renal complication NEC), E11.311 — Type 2 diabetes mellitus with unspecified diabetic retinopathy with macular edema (with, retinopathy, with macular edema), E11.319 — Type 2 diabetes mellitus with unspecified diabetic retinopathy without macular edema (with, retinopathy), +190 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

HbA1c Test (Glycated Hemoglobin), Blood Glucose Test, Gamma-glutamyl Transferase (GGT) Test, Iron Panel, Lipid Panel, Thyroid Stimulating Hormone (TSH)

Contextual Map

Every relationship of E10.43 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run E10.43 with these 14 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes (24)

Referenced by Excludes2 notes

  • H35 — Other retinal disorders[Excludes2](via E10.-): “diabetic retinal disorders (E08.311-E08.359, E09.311-E09.359, E10.311-E10.359, E11.311-E11.359, E13.311-E13.359)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
  • I96 — Gangrene, not elsewhere classified[Excludes2](via E10.-): “gangrene in diabetes mellitus (E08-E13 with .52)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
  • K31 — Other diseases of stomach and duodenum[Excludes2]: “diabetic gastroparesis (E08.43, E09.43, E10.43, E11.43, E13.43)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026

Referenced by Code First instructions

Referenced by Code Also instructions

Clinical classification (CCSR)

Risk adjustment (CMS-HCC)

  • HCC 37 — Diabetes with Chronic Complications [CMS-HCC]: “Diabetes with Chronic Complications — supersedes HCC 38 (Diabetes with Glycemic, Unspecified, or No Complications)”— CMS-HCC V28 · 2026

MS-DRG Grouper

MDC crossing

  • Pre-MDC[MDC crossing]: “Pre-MDC — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 153 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026
  • MDC 01 — Diseases and Disorders of the Nervous System[MDC crossing]: “Diseases and Disorders of the Nervous System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 8,892 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

  • Diabetes, diabetic (mellitus) (sugar), type 1, with, autonomicneuropathy (poly)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Diabetes, diabetic (mellitus) (sugar), type 1, with, gastroparalysis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Diabetes, diabetic (mellitus) (sugar), type 1, with, gastroparesis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (40)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Risk adjustment Official source data
2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "E10.43 — Type 1 diabetes mellitus with diabetic autonomic (poly)neuropathy." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/e10.43-type-1-diabetes-mellitus-with-diabetic-autonomic-polyneuropathy

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Type 1 diabetes mellitus with diabetic autonomic (poly)neuropathy

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to E10.43 in its code family, with their registry titles.

View all codes in the E10 family