Iron Panel
Serum Iron, Total Iron Binding Capacity (TIBC), Transferrin, and Transferrin Saturation.
Iron tests measure different substances in the blood to check iron levels in your body. Iron is a mineral that your body needs for growth and development. Your body uses iron to make hemoglobin, a protein in red blood cells. It carries oxygen from the lungs to all parts of the body, Iron is also important for healthy muscles, bone marrow, and organ function. Your body also needs iron to make some hormones . You get iron from eating food or taking supplements. There are iron-only supplements, but many multivitamin/mineral supplements also contain iron. Most people in the United States get enough iron. However, certain people may be more likely to have trouble getting enough iron. For example, those who: Have heavy periods Are pregnant or breastfeeding Are infants (especially if they are premature or low birth weight ) Are frequent blood donors Have cancer , certain digestive diseases , or heart failure The amount of iron you need each day depends on your age, your sex, and whether you consume a mostly plant-based diet. Iron levels that are too low or too high can cause health concerns. For example, not having enough iron in your body is the most common cause of anemia . Anemia is a condition in which your blood has a lower-than-normal amount of red blood cells. The amount of iron in your blood varies throughout the day and may be higher in the morning. There are different types of iron tests. You may just have one type of test. But in some cases, your health care provider might order several different iron tests to understand your results better. The different types of iron tests include: Serum iron test , which measures the amount of iron in the blood Transferrin test , which measures transferrin, a protein that moves iron throughout the body Total iron-binding capacity (TIBC) , which measures how well iron attaches to transferrin and other proteins in the blood Ferritin blood test , which measures how much iron is stored in the body Other names: Serum Iron, Serum Fe, Ferritin Test, Serum Ferritin
Why is this test ordered? You may need testing if you have symptoms of iron levels that are too low or too high. However, low iron may not cause symptoms until the level is very low. So, your provider may order a routine iron test to check your iron level. Symptoms of iron levels that are too low include: Weakness or fatigue Dizziness Shortness of breath Arrhythmia (a problem with the rate or rhythm of your heartbeat) Symptoms of iron levels that are too high include: Weakness or fatigue Joint pain, most often in the knees or hands Abdominal (belly) pain Loss of interest in sex or erectile dysfunction (ED) Changes in skin color, which may look gray, metallic, or bronze
Clinical Interpretation
To understand the results of your iron test, your provider will consider your symptoms, age, medical history, and the results of other blood tests. If one or more iron test results show your iron levels are too low, it may mean you have: Iron deficiency anemia, a common type of anemia. Another type of anemia. Thalassemia , a blood disorder that is inherited (passed down through families). It causes the body to make fewer than normal healthy red blood cells. If one or more iron test results show your iron levels are too high, it may mean you have: Hemochromatosis Lead poisoning Liver disease Most conditions that cause too little or too much iron can be treated with iron supplements (for low iron), changes to your diet, medicines, and/or other therapies. If your iron test results are not normal, it does not necessarily mean you have a medical condition that needs treatment. Some medicines, including birth control pills and estrogen treatments, can affect iron levels. Iron levels may also be lower for women during their menstrual cycles. If you have questions about your results, talk to your provider. Learn more about laboratory tests, reference ranges, and understanding results.
Medicare Coverage — diagnoses supporting medical necessity (NCD)
Showing 18 of 3,274 diagnoses Medicare covers for this test under NCD 190.18. The complete list is in CMS's Lab NCD code list.
Clinical Protocol & Patient Advice
- 1
Fasting is recommended; serum iron levels fluctuate throughout the day and are typically highest in the morning.
- 2
Do not take iron supplements or multivitamins containing iron for 24 hours prior to the test.
- 3
Your provider may ask you to fast (not eat or drink) for 12 hours before your test. The test is usually done in the morning. If you have any questions about how to prepare for your test, talk to your health care provider.
Usage Guidance
- A complete iron profile must interpret iron levels alongside ferritin to differentiate simple iron deficiency from anemia of chronic disease.
- Reference ranges vary by laboratory. Always discuss your specific results with a qualified healthcare professional.
Source: MedlinePlus, National Library of Medicine. View the original.
Read from: MedlinePlus (NLM); reference ranges only where NIDDK, NIH ODS or NCI states the value, linked per page — Curated from federal sources. All data sources · How to read the labels