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Q78.0 ICD-10-CM Code: Osteogenesis imperfecta

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
2 inclusion terms · 1 Excludes2

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 456 — SPINAL FUSION EXCEPT CERVICAL WITH SPINAL CURVATURE, MALIGNANCY, INFECTION OR EXTENSIVE FUSIONS WITH MCC (MDC 08)
  • MS-DRG 457 — SPINAL FUSION EXCEPT CERVICAL WITH SPINAL CURVATURE, MALIGNANCY, INFECTION OR EXTENSIVE FUSIONS WITH CC (MDC 08)
  • MS-DRG 458 — SPINAL FUSION EXCEPT CERVICAL WITH SPINAL CURVATURE, MALIGNANCY, INFECTION OR EXTENSIVE FUSIONS WITHOUT CC/MCC (MDC 08)
  • MS-DRG 564 — OTHER MUSCULOSKELETAL SYSTEM AND CONNECTIVE TISSUE DIAGNOSES WITH MCC (MDC 08)
  • MS-DRG 565 — OTHER MUSCULOSKELETAL SYSTEM AND CONNECTIVE TISSUE DIAGNOSES WITH CC (MDC 08)
  • MS-DRG 566 — OTHER MUSCULOSKELETAL SYSTEM AND CONNECTIVE TISSUE DIAGNOSES WITHOUT CC/MCC (MDC 08)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for Q78.0 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on Q78.0 itself; “inherited from” names the category or block whose note applies here.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Fragilitas ossium
  • Osteopsathyrosis

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Source: inherited from Q78

Coder workflow for Q78.0

MedCoder structured workflow — derived from this code’s own official record

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

  • Excludes2 — not part of Q78.0(1 note)

    Coding workflow: The conditions named in this note are not included in Q78.0. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareG71.13

    See the official tabular notes · Guidelines I.A.12.b

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Osteogenesis imperfecta is a billable ICD-10-CM diagnosis code (Q78.0).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (26)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Verify Before Coding

  • CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name Q78.0 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 2 Excludes1 notes: M24.3 — Pathological dislocation of joint, not elsewhere classified (via Q78.-), M85 — Other disorders of bone density and structure.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 1 Excludes2 note: M95 — Other acquired deformities of musculoskeletal system and connective tissue (via Q78.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 10 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 6 MS-DRGs: DRG 456 (MDC 08), DRG 457 (MDC 08), DRG 458 (MDC 08), DRG 564 (MDC 08), DRG 565 (MDC 08), DRG 566 (MDC 08).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):MAL008 — Musculoskeletal congenital conditions (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

Q77.3 — Chondrodysplasia punctata, Q77.6 — Chondroectodermal dysplasia, Q78.1 — Polyostotic fibrous dysplasia, Q78.2 — Osteopetrosis, Q78.3 — Progressive diaphyseal dysplasia, Q78.5 — Metaphyseal dysplasia, Q78.6 — Multiple congenital exostoses, Q78.8 — Other specified osteochondrodysplasias, Q78.9 — Osteochondrodysplasia, unspecified

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Musculoskeletal congenital conditions).

Q77.0 — Achondrogenesis, Q77.1 — Thanatophoric short stature, Q77.2 — Short rib syndrome, Q77.3 — Chondrodysplasia punctata, Q77.4 — Achondroplasia, Q77.5 — Diastrophic dysplasia, Q77.6 — Chondroectodermal dysplasia, Q77.7 — Spondyloepiphyseal dysplasia, Q77.8 — Other osteochondrodysplasia with defects of growth of tubular bones and spine, Q77.9 — Osteochondrodysplasia with defects of growth of tubular bones and spine, unspecified, Q78.1 — Polyostotic fibrous dysplasia, Q78.2 — Osteopetrosis, Q78.3 — Progressive diaphyseal dysplasia, Q78.4 — Enchondromatosis, Q78.5 — Metaphyseal dysplasia, Q78.6 — Multiple congenital exostoses, Q78.8 — Other specified osteochondrodysplasias, Q78.9 — Osteochondrodysplasia, unspecified, Q79.0 — Congenital diaphragmatic hernia, Q79.1 — Other congenital malformations of diaphragm, +245 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Brittle”, “Fragile, fragility”, “Deafness”, …; these codes share that main term but sit in a different category of the Tabular List.

M85.31 — Osteitis condensans, shoulder (condensans, shoulder), M85.32 — Osteitis condensans, upper arm (condensans, upper arm), M85.33 — Osteitis condensans, forearm (condensans, forearm), M85.34 — Osteitis condensans, hand (condensans, hand), M85.35 — Osteitis condensans, thigh (condensans, thigh), M85.36 — Osteitis condensans, lower leg (condensans, lower leg), M85.37 — Osteitis condensans, ankle and foot (condensans, toe), M85.38 — Osteitis condensans, other site (condensans, rib), M85.39 — Osteitis condensans, multiple sites (condensans, multiple site), M88.0 — Osteitis deformans of skull (deformans, skull), M88.1 — Osteitis deformans of vertebrae (deformans, vertebra), M88.9 — Osteitis deformans of unspecified bone (deformans), Q12.0 — Congenital cataract (dot cataract), Q13.5 — Blue sclera (sclera), Q24.9 — Congenital malformation of heart, unspecified (baby), Q84.6 — Other congenital malformations of nails (nails, congenital), Q95.5 — Individual with autosomal fragile site (autosomal site), Q99.2 — Fragile X chromosome (X chromosome), R48.8 — Other symbolic dysfunctions (mental), T70.0 — Otitic barotrauma (aviation), +35 more

Contextual Map

Every relationship of Q78.0 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run Q78.0 with these 3 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Excludes2 notes

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 08 — Diseases and Disorders of the Musculoskeletal System and Connective Tissue[MDC crossing]: “Diseases and Disorders of the Musculoskeletal System and Connective Tissue — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 18,508 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries (26)

  • Adair-Dighton syndrome (brittle bones and blue sclera, deafness)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Blue, sclera, with fragility of bone and deafness[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Brittle, bones disease[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Deafness (acquired) (complete) (hereditary) (partial), congenital, with blue sclera and fragility of bone[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Deafness (acquired) (complete) (hereditary) (partial), with blue sclera and fragility of bone[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Disease, diseased, Eddowes' (brittle bones and blue sclera)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Disease, diseased, Lobstein's (brittle bones and blue sclera)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Disease, diseased, Vrolik's (osteogenesis imperfecta)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • and 18 more

Nearest codes (9)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "Q78.0 — Osteogenesis imperfecta." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/q78.0-osteogenesis-imperfecta

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Osteogenesis imperfecta

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to Q78.0 in its code family, with their registry titles.

View all codes in the Q78 family