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ICD-10/T36.0X5A

T36.0X5A ICD-10-CM Code: Adverse effect of penicillins, initial encounter

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.

  • MS-DRG 791 — PREMATURITY WITH MAJOR PROBLEMS (MDC 15)
  • MS-DRG 793 — FULL TERM NEONATE WITH MAJOR PROBLEMS (MDC 15)
  • MS-DRG 917 — POISONING AND TOXIC EFFECTS OF DRUGS WITH MCC (MDC 21)
  • MS-DRG 918 — POISONING AND TOXIC EFFECTS OF DRUGS WITHOUT MCC (MDC 21)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.

Official Registry Overview & Definition

Adverse effect of penicillins, initial encounter is a billable ICD-10-CM diagnosis code (T36.0X5A).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for T36.0X5A in the official ICD-10-CM tabular list.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

  • antineoplastic antibiotics (T45.1-)
  • locally applied antibiotic NEC (T49.0)
  • topically used antibiotic for ear, nose and throat (T49.6)
  • topically used antibiotic for eye (T49.5)
  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)

Code First

Underlying conditions that must be sequenced before this code.

  • Code first, for adverse effects, the nature of the adverse effect, such as:
  • adverse effect NOS (T88.7)
  • aspirin gastritis (K29.-)
  • blood disorders (D56-D76)
  • contact dermatitis (L23-L25)
  • dermatitis due to substances taken internally (L27.-)
  • nephropathy (N14.0-N14.2)

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code(s) to specify:
  • manifestations of poisoning
  • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
  • underdosing of medication regimen (Z91.12-, Z91.13-)

Frequently Asked Questions (FAQ) & Clinical Guidance

Does T36.0X5A require a 7th character?

Yes. The appropriate 7th character is to be added to each code from category T36.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to T36.0X5A in its code family, with their registry titles.

  • T36.0X4 — Poisoning by penicillins, undetermined
  • T36.0X4A — Poisoning by penicillins, undetermined, initial encounter
  • T36.0X4D — Poisoning by penicillins, undetermined, subsequent encounter
  • T36.0X4S — Poisoning by penicillins, undetermined, sequela
  • T36.0X5 — Adverse effect of penicillins
  • T36.0X5D — Adverse effect of penicillins, subsequent encounter
  • T36.0X5S — Adverse effect of penicillins, sequela
  • T36.0X6 — Underdosing of penicillins
  • T36.0X6A — Underdosing of penicillins, initial encounter
  • T36.0X6D — Underdosing of penicillins, subsequent encounter

View all codes in the T36 family

Associated Substances (54)

Substances from the official ICD-10-CM Table of Drugs and Chemicals that map to this code.

  • Adicillin
  • Amdinocilline
  • Amoxicillin
  • Ampicillin
  • Ancillin
  • Apalcillin
  • Aspoxicillin
  • Azidocillin
  • Azlocillin
  • Bacampicillin
  • Benethamine penicillin
  • Benzathine benzylpenicillin
  • Benzathine penicillin
  • Benzylpenicillin
  • Carbenicillin
  • Carfecillin
  • Carindacillin
  • Ciclacillin
  • Clometocillin
  • Cloxacillin
  • Cyclacillin
  • Dicloxacillin
  • Epicillin
  • Flucloxacillin
  • Hetacillin
  • Hydrabamine penicillin
  • Imipenem
  • Isoxazolyl penicillin
  • Mecillinam
  • Metampicillin
  • Methicillin
  • Methoxybenzyl penicillin
  • Meticillin
  • Mezlocillin
  • Nafcillin
  • Oxacillin
  • Penamecillin
  • Penethamate
  • Penicillin (any)
  • Phenbenicillin
  • Pheneticillin
  • Phenoxymethyl penicillin
  • Phenthicillin
  • Piperacillin
  • Pivampicillin
  • Pivmecillinam
  • Propicillin
  • Sulbactam
  • Sulbenicillin
  • Sultamicillin
  • Talampicillin
  • Temocillin
  • Ticarcillin
  • Xantocillin