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ICD-10/T88.6XXD

T88.6XXD ICD-10-CM Code: Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, subsequent encounter

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.

Official Registry Overview & Definition

Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, subsequent encounter is a billable ICD-10-CM diagnosis code (T88.6D).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for T88.6XXD in the official ICD-10-CM tabular list.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
  • Anaphylactoid reaction NOS

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

  • anaphylactic reaction due to serum (T80.5-)
  • anaphylactic shock or reaction due to adverse food reaction (T78.0-)

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

  • complication following infusion, transfusion and therapeutic injection (T80.-)
  • complication following procedure NEC (T81.-)
  • complications of anesthesia in labor and delivery (O74.-)
  • complications of anesthesia in pregnancy (O29.-)
  • complications of anesthesia in puerperium (O89.-)
  • complications of devices, implants and grafts (T82-T85)
  • complications of obstetric surgery and procedure (O75.4)
  • dermatitis due to drugs and medicaments (L23.3, L24.4, L25.1, L27.0-L27.1)
  • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4)
  • specified complications classified elsewhere
  • any encounters with medical care for postprocedural conditions in which no complications are present, such as:
  • artificial opening status (Z93.-)
  • closure of external stoma (Z43.-)
  • fitting and adjustment of external prosthetic device (Z44.-)
  • burns and corrosions from local applications and irradiation (T20-T32)
  • complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
  • mechanical complication of respirator ventilator
  • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
  • postprocedural fever (R50.82)
  • specified complications classified elsewhere, such as:
  • cerebrospinal fluid leak from spinal puncture (G97.0)
  • colostomy malfunction (K94.0-)
  • disorders of fluid and electrolyte imbalance (E86-E87)
  • functional disturbances following cardiac surgery (I97.0-I97.1)
  • intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
  • ostomy complications (J95.0-, K94.-, N99.5-)
  • postgastric surgery syndromes (K91.1)
  • postlaminectomy syndrome NEC (M96.1)
  • postmastectomy lymphedema syndrome (I97.2)
  • postsurgical blind-loop syndrome (K91.2)
  • ventilator associated pneumonia (J95.851)

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • Use additional code(s) to identify the specified condition resulting from the complication
  • Use additional code to identify devices involved and details of circumstances (Y62-Y82)

Frequently Asked Questions (FAQ) & Clinical Guidance

Does T88.6XXD require a 7th character?

Yes. The appropriate 7th character is to be added to each code from category T88.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to T88.6XXD in its code family, with their registry titles.

  • T88.59XA — Other complications of anesthesia, initial encounter
  • T88.59XD — Other complications of anesthesia, subsequent encounter
  • T88.59XS — Other complications of anesthesia, sequela
  • T88.6 — Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered
  • T88.6XXA — Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, initial encounter
  • T88.6XXS — Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered, sequela
  • T88.7 — Unspecified adverse effect of drug or medicament
  • T88.7XXA — Unspecified adverse effect of drug or medicament, initial encounter
  • T88.7XXD — Unspecified adverse effect of drug or medicament, subsequent encounter
  • T88.7XXS — Unspecified adverse effect of drug or medicament, sequela

View all codes in the T88 family