00C54ZZ ICD-10-PCS Code: Extirpation of Matter from Intracranial Subarachnoid Space, Percutaneous Endoscopic Approach

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

The MS-DRG grouper treats this as an operating room procedure. It appears in the surgical logic of 15 MS-DRGs:

• MDC 01 — Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis: DRG 023, DRG 024
• MDC 01 — Craniotomy and endovascular intracranial procedures: DRG 025, DRG 026, DRG 027
• MDC 17 — Lymphoma and Leukemia with Major O.R. Procedures: DRG 820, DRG 821, DRG 822
• MDC 17 — Myeloproliferative Disorders or Poorly Differentiated Neoplasms with Major O.R. Procedures: DRG 826, DRG 827, DRG 828
• MDC 21 — Other O.R. Procedures for Injuries: DRG 907, DRG 908, DRG 909
• MDC 24 — Craniotomy for Multiple Significant Trauma: DRG 955

From the CMS MS-DRG Definitions Manual, Appendix E. Actual DRG assignment depends on the complete claim.

Related Codes

Same operation — other Body Part

Same table and root operation, differing only in the body part character.

00C14ZZ — Extirpation of Matter from Cerebral Meninges, Percutaneous Endoscopic Approach, 00C24ZZ — Extirpation of Matter from Dura Mater, Percutaneous Endoscopic Approach, 00C34ZZ — Extirpation of Matter from Intracranial Epidural Space, Percutaneous Endoscopic Approach, 00C44ZZ — Extirpation of Matter from Intracranial Subdural Space, Percutaneous Endoscopic Approach, 00C64ZZ — Extirpation of Matter from Cerebral Ventricle, Percutaneous Endoscopic Approach, 00C74ZZ — Extirpation of Matter from Cerebral Hemisphere, Percutaneous Endoscopic Approach, 00C84ZZ — Extirpation of Matter from Basal Ganglia, Percutaneous Endoscopic Approach, 00C94ZZ — Extirpation of Matter from Thalamus, Percutaneous Endoscopic Approach, +22 more

Same operation — other Approach

Same table and root operation, differing only in the approach character.

00C50ZZ — Extirpation of Matter from Intracranial Subarachnoid Space, Open Approach, 00C53ZZ — Extirpation of Matter from Intracranial Subarachnoid Space, Percutaneous Approach

Same procedure category (CCSR), other tables

AHRQ's Clinical Classifications Software Refined groups these ICD-10-PCS procedures with this one under Other CNS drainage and related procedures (Central Nervous System Procedures); listed here are the members in other PCS tables. Source: Clinical Classifications Software Refined (CCSR), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, November 2025.

009S30Z — Drainage of Hypoglossal Nerve with Drainage Device, Percutaneous Approach, 009S3ZZ — Drainage of Hypoglossal Nerve, Percutaneous Approach, 009S40Z — Drainage of Hypoglossal Nerve with Drainage Device, Percutaneous Endoscopic Approach, 009S4ZZ — Drainage of Hypoglossal Nerve, Percutaneous Endoscopic Approach, 009T00Z — Drainage of Spinal Meninges with Drainage Device, Open Approach, 009T0ZZ — Drainage of Spinal Meninges, Open Approach, 009T30Z — Drainage of Spinal Meninges with Drainage Device, Percutaneous Approach, 009T3ZZ — Drainage of Spinal Meninges, Percutaneous Approach, 009T40Z — Drainage of Spinal Meninges with Drainage Device, Percutaneous Endoscopic Approach, 009T4ZZ — Drainage of Spinal Meninges, Percutaneous Endoscopic Approach, 00F50ZZ — Fragmentation in Intracranial Subarachnoid Space, Open Approach, 00F53ZZ — Fragmentation in Intracranial Subarachnoid Space, Percutaneous Approach, 00F54ZZ — Fragmentation in Intracranial Subarachnoid Space, Percutaneous Endoscopic Approach, 00F5XZZ — Fragmentation in Intracranial Subarachnoid Space, External Approach, 00F60ZZ — Fragmentation in Cerebral Ventricle, Open Approach, 00F63ZZ — Fragmentation in Cerebral Ventricle, Percutaneous Approach, 00F64ZZ — Fragmentation in Cerebral Ventricle, Percutaneous Endoscopic Approach, 00F6XZZ — Fragmentation in Cerebral Ventricle, External Approach, 00P000Z — Removal of Drainage Device from Brain, Open Approach, 00P030Z — Removal of Drainage Device from Brain, Percutaneous Approach, +185 more

Contextual Map

Every relationship of 00C54ZZ in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run 00C54ZZ with these 5 related codes in Claim Check

PCS table

• 00C[PCS table]— CMS ICD-10-PCS tables
• Medical and Surgical — Section: Medical and Surgical[Section]: “Medical and Surgical”— CMS ICD-10-PCS tables
• Central Nervous System and Cranial Nerves — Body System: Central Nervous System and Cranial Nerves[Body System]: “Central Nervous System and Cranial Nerves”— CMS ICD-10-PCS tables
• Extirpation — Operation: Extirpation[Operation]: “Extirpation”— CMS ICD-10-PCS tables

MS-DRG participation (15)

• DRG 023 — CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITH MCC OR ANTINEOPLASTIC IMPLANT OR EPILEPSY WITH NEUROSTIMULATOR[MS-DRG]: “CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITH MCC OR ANTINEOPLASTIC IMPLANT OR EPILEPSY WITH NEUROSTIMULATOR — Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026
• DRG 024 — CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITHOUT MCC[MS-DRG]: “CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITHOUT MCC — Craniotomy with Major Device Implant or Acute Complex CNS Principal Diagnosis (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026
• DRG 025 — CRANIOTOMY AND ENDOVASCULAR INTRACRANIAL PROCEDURES WITH MCC[MS-DRG]: “CRANIOTOMY AND ENDOVASCULAR INTRACRANIAL PROCEDURES WITH MCC — Craniotomy and endovascular intracranial procedures (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026
• DRG 026 — CRANIOTOMY AND ENDOVASCULAR INTRACRANIAL PROCEDURES WITH CC[MS-DRG]: “CRANIOTOMY AND ENDOVASCULAR INTRACRANIAL PROCEDURES WITH CC — Craniotomy and endovascular intracranial procedures (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026
• DRG 027 — CRANIOTOMY AND ENDOVASCULAR INTRACRANIAL PROCEDURES WITHOUT CC/MCC[MS-DRG]: “CRANIOTOMY AND ENDOVASCULAR INTRACRANIAL PROCEDURES WITHOUT CC/MCC — Craniotomy and endovascular intracranial procedures (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026
• DRG 820 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH MCC[MS-DRG]: “LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH MCC — Lymphoma and Leukemia with Major O.R. Procedures (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026
• DRG 821 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH CC[MS-DRG]: “LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH CC — Lymphoma and Leukemia with Major O.R. Procedures (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026
• DRG 822 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITHOUT CC/MCC[MS-DRG]: “LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITHOUT CC/MCC — Lymphoma and Leukemia with Major O.R. Procedures (MDC 17)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026
• and 7 more

Clinical classification (CCSR)

• CNS006 — Other CNS drainage and related procedures[CCSR category]: “Other CNS drainage and related procedures — Central Nervous System Procedures”— AHRQ CCSR for ICD-10-PCS Procedures (HCUP) · v2026.1

MDC crossing · diagnoses (3301)

• MDC 01 — Diseases and Disorders of the Nervous System[MDC crossing]: “Diseases and Disorders of the Nervous System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”— CMS MS-DRG Definitions Manual · FY2026
• MDC 17 — Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms[MDC crossing]: “Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”— CMS MS-DRG Definitions Manual · FY2026
• A02.21 — Salmonella meningitis[Same-MDC diagnosis]: “Salmonella meningitis — grouped in MDC 01, the diagnosis side of this code's crossing.”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• A06.6 — Amebic brain abscess[Same-MDC diagnosis]: “Amebic brain abscess — grouped in MDC 01, the diagnosis side of this code's crossing.”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• A17.0 — Tuberculous meningitis[Same-MDC diagnosis]: “Tuberculous meningitis — grouped in MDC 01, the diagnosis side of this code's crossing.”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• A17.1 — Meningeal tuberculoma[Same-MDC diagnosis]: “Meningeal tuberculoma — grouped in MDC 01, the diagnosis side of this code's crossing.”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• A17.81 — Tuberculoma of brain and spinal cord[Same-MDC diagnosis]: “Tuberculoma of brain and spinal cord — grouped in MDC 01, the diagnosis side of this code's crossing.”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• and 3296 more

Nearest codes

• 00C04ZZ — Extirpation of Matter from Brain, Percutaneous Endoscopic Approach[One axis away]— CMS ICD-10-PCS tables
• 00C14ZZ — Extirpation of Matter from Cerebral Meninges, Percutaneous Endoscopic Approach[One axis away]— CMS ICD-10-PCS tables
• 00C24ZZ — Extirpation of Matter from Dura Mater, Percutaneous Endoscopic Approach[One axis away]— CMS ICD-10-PCS tables
• 00C34ZZ — Extirpation of Matter from Intracranial Epidural Space, Percutaneous Endoscopic Approach[One axis away]— CMS ICD-10-PCS tables
• 00C44ZZ — Extirpation of Matter from Intracranial Subdural Space, Percutaneous Endoscopic Approach[One axis away]— CMS ICD-10-PCS tables
• 00C50ZZ — Extirpation of Matter from Intracranial Subarachnoid Space, Open Approach[One axis away]— CMS ICD-10-PCS tables
• 00C53ZZ — Extirpation of Matter from Intracranial Subarachnoid Space, Percutaneous Approach[One axis away]— CMS ICD-10-PCS tables
• 00C64ZZ — Extirpation of Matter from Cerebral Ventricle, Percutaneous Endoscopic Approach[One axis away]— CMS ICD-10-PCS tables