3E040TZ ICD-10-PCS Code: Introduction of Destructive Agent into Central Vein, Open Approach

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

The MS-DRG grouper treats this as an operating room procedure. It appears in the surgical logic of 4 MS-DRGs:

• MDC 01 — Extracranial Procedures: DRG 037, DRG 038, DRG 039
• MDC 05 — Vein Ligation and Stripping: DRG 263

From the CMS MS-DRG Definitions Manual, Appendix E. Actual DRG assignment depends on the complete claim.

Related Codes

Same operation — other Body System / Region

Same table and root operation, differing only in the body system / region character.

3E030TZ — Introduction of Destructive Agent into Peripheral Vein, Open Approach, 3E050TZ — Introduction of Destructive Agent into Peripheral Artery, Open Approach, 3E060TZ — Introduction of Destructive Agent into Central Artery, Open Approach, 3E0Q0TZ — Introduction of Destructive Agent into Cranial Cavity and Brain, Open Approach

Same operation — other Approach

Same table and root operation, differing only in the approach character.

3E043TZ — Introduction of Destructive Agent into Central Vein, Percutaneous Approach

Same operation — other Substance

Same table and root operation, differing only in the substance character.

3E0407Z — Introduction of Electrolytic and Water Balance Substance into Central Vein, Open Approach, 3E040FZ — Introduction of Intracirculatory Anesthetic into Central Vein, Open Approach, 3E040HZ — Introduction of Radioactive Substance into Central Vein, Open Approach, 3E040KZ — Introduction of Other Diagnostic Substance into Central Vein, Open Approach, 3E040NZ — Introduction of Analgesics, Hypnotics, Sedatives into Central Vein, Open Approach, 3E040PZ — Introduction of Platelet Inhibitor into Central Vein, Open Approach, 3E040RZ — Introduction of Antiarrhythmic into Central Vein, Open Approach, 3E040XZ — Introduction of Vasopressor into Central Vein, Open Approach, +3 more

Same procedure category (CCSR), other tables

AHRQ's Clinical Classifications Software Refined groups these ICD-10-PCS procedures with this one under Administration of therapeutic substances, NEC (Administration of Therapeutic Substances); listed here are the members in other PCS tables. Source: Clinical Classifications Software Refined (CCSR), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality, November 2025.

XW00X27 — Introduction of Anacaulase-bcdb into Skin, External Approach, New Technology Group 7, XW0136A — Introduction of Dasiglucagon into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 10, XW01397 — Introduction of Satralizumab-mwge into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 7, XW013TB — Introduction of Rozanolixizumab-noli Monoclonal Antibody into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 11, XW013W5 — Introduction of Caplacizumab into Subcutaneous Tissue, Percutaneous Approach, New Technology Group 5, XW01X27 — Introduction of Anacaulase-bcdb into Subcutaneous Tissue, External Approach, New Technology Group 7, XW0333A — Introduction of Bentracimab, Ticagrelor Reversal Agent into Peripheral Vein, Percutaneous Approach, New Technology Group 10, XW03372 — Introduction of Inactivated Coagulation Factor Xa into Peripheral Vein, Percutaneous Approach, New Technology Group 2, XW03377 — Introduction of Trilaciclib into Peripheral Vein, Percutaneous Approach, New Technology Group 7, XW033F3 — Introduction of Other New Technology Therapeutic Substance into Peripheral Vein, Percutaneous Approach, New Technology Group 3, XW033FA — Introduction of Non-Chimeric Antigen Receptor T-cell Immune Effector Cell Therapy into Peripheral Vein, Percutaneous Approach, New Technology Group 10, XW033FB — Introduction of Valoctocogene Roxaparvovec-rvox into Peripheral Vein, Percutaneous Approach, New Technology Group 11, XW033MA — Introduction of Emapalumab-lzsg Anti-IFNy Monoclonal Antibody into Peripheral Vein, Percutaneous Approach, New Technology Group 10, XW033Q9 — Introduction of Posoleucel into Peripheral Vein, Percutaneous Approach, New Technology Group 9, XW033QB — Introduction of Iloprost into Peripheral Vein, Percutaneous Approach, New Technology Group 11, XW033R9 — Introduction of Rezafungin into Peripheral Vein, Percutaneous Approach, New Technology Group 9, XW033W5 — Introduction of Caplacizumab into Peripheral Vein, Percutaneous Approach, New Technology Group 5, XW0433A — Introduction of Bentracimab, Ticagrelor Reversal Agent into Central Vein, Percutaneous Approach, New Technology Group 10, XW04372 — Introduction of Inactivated Coagulation Factor Xa into Central Vein, Percutaneous Approach, New Technology Group 2, XW04377 — Introduction of Trilaciclib into Central Vein, Percutaneous Approach, New Technology Group 7, +38 more

Contextual Map

Every relationship of 3E040TZ in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run 3E040TZ with these 5 related codes in Claim Check

PCS table

• 3E0[PCS table]— CMS ICD-10-PCS tables
• Administration — Section: Administration[Section]: “Administration”— CMS ICD-10-PCS tables
• Physiological Systems and Anatomical Regions — Body System: Physiological Systems and Anatomical Regions[Body System]: “Physiological Systems and Anatomical Regions”— CMS ICD-10-PCS tables
• Introduction — Operation: Introduction[Operation]: “Introduction”— CMS ICD-10-PCS tables

MS-DRG participation

• DRG 037 — EXTRACRANIAL PROCEDURES WITH MCC[MS-DRG]: “EXTRACRANIAL PROCEDURES WITH MCC — Extracranial Procedures (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026
• DRG 038 — EXTRACRANIAL PROCEDURES WITH CC[MS-DRG]: “EXTRACRANIAL PROCEDURES WITH CC — Extracranial Procedures (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026
• DRG 039 — EXTRACRANIAL PROCEDURES WITHOUT CC/MCC[MS-DRG]: “EXTRACRANIAL PROCEDURES WITHOUT CC/MCC — Extracranial Procedures (MDC 01)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026
• DRG 263 — VEIN LIGATION AND STRIPPING[MS-DRG]: “VEIN LIGATION AND STRIPPING — Vein Ligation and Stripping (MDC 05)”— CMS MS-DRG Definitions Manual (Appendix E) · FY2026

Clinical classification (CCSR)

• ADM021 — Administration of therapeutic substances, NEC[CCSR category]: “Administration of therapeutic substances, NEC — Administration of Therapeutic Substances”— AHRQ CCSR for ICD-10-PCS Procedures (HCUP) · v2026.1

MDC crossing · diagnoses (4480)

• MDC 01 — Diseases and Disorders of the Nervous System[MDC crossing]: “Diseases and Disorders of the Nervous System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”— CMS MS-DRG Definitions Manual · FY2026
• MDC 05 — Diseases and Disorders of the Circulatory System[MDC crossing]: “Diseases and Disorders of the Circulatory System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs.”— CMS MS-DRG Definitions Manual · FY2026
• A02.21 — Salmonella meningitis[Same-MDC diagnosis]: “Salmonella meningitis — grouped in MDC 01, the diagnosis side of this code's crossing.”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• A06.6 — Amebic brain abscess[Same-MDC diagnosis]: “Amebic brain abscess — grouped in MDC 01, the diagnosis side of this code's crossing.”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• A17.0 — Tuberculous meningitis[Same-MDC diagnosis]: “Tuberculous meningitis — grouped in MDC 01, the diagnosis side of this code's crossing.”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• A17.1 — Meningeal tuberculoma[Same-MDC diagnosis]: “Meningeal tuberculoma — grouped in MDC 01, the diagnosis side of this code's crossing.”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• A17.81 — Tuberculoma of brain and spinal cord[Same-MDC diagnosis]: “Tuberculoma of brain and spinal cord — grouped in MDC 01, the diagnosis side of this code's crossing.”— CMS MS-DRG Definitions Manual (Appendix B) · FY2026
• and 4475 more

Nearest codes

• 3E030TZ — Introduction of Destructive Agent into Peripheral Vein, Open Approach[One axis away]— CMS ICD-10-PCS tables
• 3E0403Z — Introduction of Anti-inflammatory into Central Vein, Open Approach[One axis away]— CMS ICD-10-PCS tables
• 3E0404Z — Introduction of Serum, Toxoid and Vaccine into Central Vein, Open Approach[One axis away]— CMS ICD-10-PCS tables
• 3E0406Z — Introduction of Nutritional Substance into Central Vein, Open Approach[One axis away]— CMS ICD-10-PCS tables
• 3E0407Z — Introduction of Electrolytic and Water Balance Substance into Central Vein, Open Approach[One axis away]— CMS ICD-10-PCS tables
• 3E040FZ — Introduction of Intracirculatory Anesthetic into Central Vein, Open Approach[One axis away]— CMS ICD-10-PCS tables
• 3E040HZ — Introduction of Radioactive Substance into Central Vein, Open Approach[One axis away]— CMS ICD-10-PCS tables
• 3E040KZ — Introduction of Other Diagnostic Substance into Central Vein, Open Approach[One axis away]— CMS ICD-10-PCS tables