Alka-Seltzer Plus Cold Orange Zest

NDC 0280-1510 · Bayer HealthCare LLC.

Generic nameAspirin, Chlorpheniramine Maleate, Phenylephrine bitartrate

Dosage formTABLET, EFFERVESCENT

RouteORAL

Active ingredient(s)ASPIRIN, CHLORPHENIRAMINE MALEATE, PHENYLEPHRINE BITARTRATE

Strength325; 2; 7.8 mg/1; mg/1; mg/1

Pharmacologic classAdrenergic alpha1-Agonists [MoA], Anti-Inflammatory Agents, Non-Steroidal [CS], Cyclooxygenase Inhibitors [MoA], Decreased Platelet Aggregation [PE], Decreased Prostaglandin Production [PE], Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC], Nonsteroidal Anti-inflammatory Drug [EPC], Platelet Aggregation Inhibitor [EPC], alpha-1 Adrenergic Agonist [EPC]

Marketing categoryOTC MONOGRAPH DRUG

Packages

0280-1510-20 — 10 POUCH in 1 CARTON (0280-1510-20) / 2 TABLET, EFFERVESCENT in 1 POUCH

Related Codes

Same active ingredient

FDA lists these products with the same active ingredient.

0280-0088 — chlorpheniramine maleate, acetaminophen, phenylephrine hydrochloride, dextromethorphan hydrobromide, 0280-0092 — Acetaminophen, Chlorpheniramine malaeate, Dextromethorphan hydrobromide, Phenylephrine hydrochloride, 0280-0103 — Aspirin/Caffeine Oral Powder, 0280-0121 — aspirin, chlorpheniramine maleate, dextromethorphan hydrobromide, phenylephrine bitartrate, 0280-0151 — chlorpheniramine maleate, acetaminophen, dextromethorphan hydrobromide, 0280-0160 — ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE, 0280-0161 — Aspirin, 0280-0162 — Aspirin,Caffeine, 0280-0211 — Anhydrous Citric Acid, Sodium Bicarbonate, and Aspirin, 0280-1400 — ASPIRIN, CHLORPHENIRAMINE MALEATE, and PHENYLEPHRINE BITARTRATE, 0280-1520 — Aspirin, Chlorpheniramine maleate, Phenylephrine bitartrate, 0280-1545 — Aspirin, Dextromethorphan hydrobromide, Doxylamine succinate, Phenylephrine bitartrate, 0280-1555 — Aspirin, Chlorpheniramine maleate, Dextromethorphan hydrobromide, Phenylephrine bitartrate, 0280-1570 — Acetaminophen, Chlorpheniramine maleate, Dextromethorphan hydrobromide, Phenylephrine hydrochloride, 0280-2000 — Aspirin, 0280-2020 — BAYER Aspirin Extra Strength, 0280-2080 — Aspirin, 0280-2090 — Aspirin, 0280-2100 — Aspirin, 0280-2110 — Aspirin, +960 more

From the FDA National Drug Code Directory, retrieved August 24, 2026. Product listings are submitted by labelers; FDA does not verify them.

Read from: FDA National Drug Code Directory, product.txt and package.txt (accessdata.fda.gov/cder/ndctext.zip) — Snapshot retrieved 2026-08-24, loaded 2026-08-24; CMS Medicare Part B Drug Average Sales Price (ASP) Pricing Files (cms.gov/medicare/payment/part-b-drugs/asp-pricing-files) -- the NDC-HCPCS crosswalk and Part B payment limit files — 2026 Q3 (July 2026 release). All data sources · How to read the labels