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Signature Care Nighttime Severe Cold and Flu Relief

NDC 21130-129 · Safeway

Generic nameAcetaminophen, Dextromethorphan HBr, Doxylamine Succinate, Phenylephrine HCl
Dosage formSOLUTION
RouteORAL
Active ingredient(s)ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE, PHENYLEPHRINE HYDROCHLORIDE
Strength650; 20; 12.5; 10 mg/30mL; mg/30mL; mg/30mL; mg/30mL
Pharmacologic classAdrenergic alpha1-Agonists [MoA], Antihistamine [EPC], Histamine Receptor Antagonists [MoA], Sigma-1 Agonist [EPC], Sigma-1 Receptor Agonists [MoA], Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC], Uncompetitive NMDA Receptor Antagonists [MoA], alpha-1 Adrenergic Agonist [EPC]
Marketing categoryOTC MONOGRAPH DRUG

Packages

21130-129-40 — 355 mL in 1 BOTTLE (21130-129-40)

Related Codes

Same active ingredient

FDA lists these products with the same active ingredient.

21130-036 — Acetaminophen, Dextromethorphan HBr, Guaifenesin, Phenylephrine HCl, 21130-037 — Acetaminophen, Aspirin, Caffeine, 21130-043 — Acetaminophen, 21130-044 — Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, 21130-074 — acetaminophen, aspirin and caffeine, 21130-091 — acetaminophen, dextromethorphan hbr, guaifenesin, phenylephrine hcl, 21130-095 — Acetaminophen and Diphenhydramine Hydrochloride, 21130-097 — Acetaminophen, 21130-108 — Acetaminophen, 21130-111 — Acetaminophen, 21130-155 — Acetaminophen, 21130-162 — Dextromethorphan Hydrobromide, Guaifenesin, and Phenylephrine Hydrochloride, 21130-178 — Acetaminophen, 21130-223 — acetaminophen, 21130-224 — Acetaminophen and Diphenhydramine hydrochloride, 21130-243 — Acetaminophen, 21130-270 — Acetaminophen, 21130-285 — Acetaminophen, 21130-343 — Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, 21130-353 — Acetaminophen, +4930 more

From the FDA National Drug Code Directory, retrieved August 24, 2026. Product listings are submitted by labelers; FDA does not verify them.