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Day Time Cold and Flu

NDC 21130-580 · Safeway, Inc.

Generic nameAcetaminophen Dextromethorphan HBr Phenylephrine HCl
Dosage formLIQUID
RouteORAL
Active ingredient(s)ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE HYDROCHLORIDE
Strength325; 10; 5 mg/15mL; mg/15mL; mg/15mL
Pharmacologic classAdrenergic alpha1-Agonists [MoA], Sigma-1 Agonist [EPC], Sigma-1 Receptor Agonists [MoA], Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC], Uncompetitive NMDA Receptor Antagonists [MoA], alpha-1 Adrenergic Agonist [EPC]
Marketing categoryOTC MONOGRAPH DRUG

Packages

21130-580-08 — 237 mL in 1 BOTTLE, PLASTIC (21130-580-08)

21130-580-12 — 355 mL in 1 BOTTLE, PLASTIC (21130-580-12)

Related Codes

Same active ingredient

FDA lists these products with the same active ingredient.

21130-454 — dextromethorphan hydrobromide, guaifenesin, 21130-474 — Acetaminophen, Phenylephrine HCl, 21130-492 — Acetaminophen, 21130-499 — Dextromethorphan Hydrobromide, Doxylamine Succinate, 21130-502 — Acetaminophen, Phenylephrine HCl, 21130-505 — Dextromethorphan HBr, Guaifenesin, 21130-520 — dextromethorphan polistirex, 21130-538 — dextromethorphan polistirex, 21130-569 — Acetaminophen, Aspirin, Caffeine, 21130-577 — mineral oil, petrolatum, phenylephrine HCl, 21130-583 — Dextromethorphan HBr, Guaifenesin, 21130-586 — Acetaminophen, Aspirin, Caffeine, 21130-598 — Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride, 21130-603 — Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, 21130-615 — Acetaminophen, Guaifenesin, Phenylephrine HCl, 21130-627 — Acetaminophen, Guaifenesin, Phenylephrine HCl, 21130-628 — cocoa butter, phenylephrine HCl, 21130-650 — Acetaminophen, Dextromethorphan Hydrobromide, Phenylephrine Hydrochloride, 21130-661 — Acetaminophen and Diphenhydramine HCL, 21130-681 — Acetaminophen, Aspirin and Caffeine, +4867 more

From the FDA National Drug Code Directory, retrieved August 24, 2026. Product listings are submitted by labelers; FDA does not verify them.

Read from: FDA National Drug Code Directory, product.txt and package.txt (accessdata.fda.gov/cder/ndctext.zip) — Snapshot retrieved 2026-08-24, loaded 2026-08-24; CMS Medicare Part B Drug Average Sales Price (ASP) Pricing Files (cms.gov/medicare/payment/part-b-drugs/asp-pricing-files) -- the NDC-HCPCS crosswalk and Part B payment limit files — 2026 Q3 (July 2026 release). All data sources · How to read the labels