TYLENOL Cold Plus Flu

NDC 50580-402 · Kenvue Brands LLC

Generic nameAcetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, and Phenylephrine Hydrochloride

Dosage formTABLET, FILM COATED

RouteORAL

Active ingredient(s)ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE

Strength325; 10; 200; 5 mg/1; mg/1; mg/1; mg/1

Pharmacologic classAdrenergic alpha1-Agonists [MoA], Decreased Respiratory Secretion Viscosity [PE], Expectorant [EPC], Increased Respiratory Secretions [PE], Sigma-1 Agonist [EPC], Sigma-1 Receptor Agonists [MoA], Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC], Uncompetitive NMDA Receptor Antagonists [MoA], alpha-1 Adrenergic Agonist [EPC]

Marketing categoryOTC MONOGRAPH DRUG

Packages

50580-402-01 — 2 TABLET, FILM COATED in 1 POUCH (50580-402-01)

50580-402-02 — 50 POUCH in 1 CARTON (50580-402-02) / 2 TABLET, FILM COATED in 1 POUCH

50580-402-26 — 2 BLISTER PACK in 1 CARTON (50580-402-26) / 12 TABLET, FILM COATED in 1 BLISTER PACK

50580-402-72 — 3 CARTON in 1 PACKAGE (50580-402-72) / 2 BLISTER PACK in 1 CARTON / 12 TABLET, FILM COATED in 1 BLISTER PACK

Related Codes

Same active ingredient

FDA lists these products with the same active ingredient.

50580-213 — Acetaminophen, Dextromethorphan Hydrobromide, 50580-243 — Acetaminophen, Dextromethorphan Hydrobromide and Doxylamine Succinate., 50580-245 — Acetaminophen, Chlorpheniramine Maleate, and Dextromethorphan Hydrobromide, 50580-299 — Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hydrobromide, and Phenylephrine Hydrochloride, 50580-309 — acetaminophen, 50580-325 — Acetaminophen, 50580-341 — Diphenhydramine hydrochloride and Phenylephrine hydrochloride, 50580-344 — acetaminophen, Pseudoephedrine hydrochloride, and Dextromethorphan Hydrobromide, 50580-369 — Acetaminophen, Dextromethorphan Hydrobromide, Doxylamine Succinate, and Phenylephrine Hydrochloride, 50580-378 — Acetaminophen, 50580-403 — Acetaminophen, dextromethorphan hydrobromide, guaifenesin, and phenylephrine hydrochloride, 50580-415 — Diphenhydramine Hydrochloride and Phenylephrine Hydrochloride, 50580-424 — ACETAMINOPHEN, 50580-433 — Acetaminophen, 50580-435 — Acetaminophen and Phenylephrine hydrochloride, 50580-436 — Ibuprofen and Phenylephrine Hydrochloride, 50580-437 — Phenylephrine Hydrochloride, 50580-446 — Acetaminophen and Dextromethorphan Hydrobromide, 50580-447 — acetaminophen, guaifenesin, and phenylephrine hydrochloride, 50580-449 — Acetaminophen, +5267 more

From the FDA National Drug Code Directory, retrieved August 24, 2026. Product listings are submitted by labelers; FDA does not verify them.