XL-3 Xtreme

NDC 76281-305 · AptaPharma Inc.

Generic nameAcetaminophen, Dextromethorphan HBr, Doxylamine Succinate

Dosage formLIQUID

RouteORAL

Active ingredient(s)ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE

Strength650; 30; 12.5 mg/30mL; mg/30mL; mg/30mL

Pharmacologic classAntihistamine [EPC], Histamine Receptor Antagonists [MoA], Sigma-1 Agonist [EPC], Sigma-1 Receptor Agonists [MoA], Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC], Uncompetitive NMDA Receptor Antagonists [MoA]

Marketing categoryOTC MONOGRAPH DRUG

Packages

76281-305-28 — 354 mL in 1 BOTTLE (76281-305-28)

Related Codes

Same active ingredient

FDA lists these products with the same active ingredient.

76162-751 — DEXTROMETHORPHAN HBr AND GUAIFENESIN, 76162-792 — Acetaminophen, Chlorpheniramine Maleate, and Dextromethorphan Hydrobromide, 76162-811 — Acetaminophen, Dextromethorphan hydrobromide, Guaifenesin, Phenylephrine hydrochloride, 76162-812 — Acetaminophen, Dextromethorphan hydrobromide, Doxylamine succinate, Phenylephrine hydrochloride, 76162-912 — Acetaminophen, Dextromethorphan HBr, Phenylephrine HCl, 76162-913 — Acetaminophen, Dextromethorphan HBr, Doxylamine succinate, Phenylephrine HCl, 76168-056 — Acetaminophen,Dextromethorphan,Doxylamine, 76168-119 — Acetaminophen PM, 76168-120 — Acetaminophen, 76281-304 — ACETAMINOPHEN, DEXTROMETHORPHAN HBR, PHENYLEPHRINE HCL, 76281-306 — ACETAMINOPHEN, DEXTROMETHORPHAN HBR, PHENYLEPHRINE HCL, 76281-307 — Acetaminophen, Dextromethorphan HBr, Doxylamine Succinate, 76281-501 — ACETAMINOPHEN, 76281-502 — ACETAMINOPHEN, 76281-503 — DEXTROMETHORPHAN HYDROBROMIDE, 76281-504 — DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE, 76281-506 — Acetaminophen, Dextromethorphan HBr, Phenylephrine HCl, 76281-512 — DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, 76281-515 — ACETAMINOPHEN, GUAIFENESIN, PHENYLEPHRINE HCl, 76281-517 — Dextromethorphan HBr, GUaifenesin, Phenylephrine HCL, +4482 more

From the FDA National Drug Code Directory, retrieved August 24, 2026. Product listings are submitted by labelers; FDA does not verify them.

Read from: FDA National Drug Code Directory, product.txt and package.txt (accessdata.fda.gov/cder/ndctext.zip) — Snapshot retrieved 2026-08-24, loaded 2026-08-24; CMS Medicare Part B Drug Average Sales Price (ASP) Pricing Files (cms.gov/medicare/payment/part-b-drugs/asp-pricing-files) -- the NDC-HCPCS crosswalk and Part B payment limit files — 2026 Q3 (July 2026 release). All data sources · How to read the labels