C49.6 vs D48.1

C49.6 (Malignant neoplasm of connective and soft tissue of trunk, unspecified) compared with D48.1 (Neoplasm of uncertain behavior of connective and other soft tissue), from the official CMS tabular data. C49.6 and D48.1 name the same anatomical site (connective tissue) with a different neoplasm behavior.

Relationship

Informational

Neoplasm table relationship

D48.1

Neoplasm of uncertain behavior of connective and other soft tissue

↔

C49.6

Malignant neoplasm of connective and soft tissue of trunk, unspecified

Same anatomical site, different neoplasm behavior.

Same site — primary malignancy (connective tissue)

The behavior documented for the site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column of the neoplasm table, and therefore which code, applies.

Source: CMS Table of Neoplasms

Can these codes be reported together?

Same site, different neoplasm behavior. D48.1 and C49.6 name the same anatomical site (connective tissue) with a different neoplasm behavior.

From the CMS Table of Neoplasms: the behavior documented for that site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column, and therefore which code, applies.

Side by side

	C49.6Malignant neoplasm of connective and soft tissue of trunk, unspecified	D48.1Neoplasm of uncertain behavior of connective and other soft tissue
Billing status	Billable	Non-billable header Report instead: D48.110, D48.111, D48.112, D48.113, D48.114
Classification	C00-D49 — Neoplasms (C00-D49)	C00-D49 — Neoplasms (C00-D49)
Definition	Malignant neoplasm of connective and soft tissue of trunk, unspecified is a billable ICD-10-CM diagnosis code (C49.6).	Neoplasm of uncertain behavior of connective and other soft tissue is a non-billable ICD-10-CM category code (D48.1).
Includes	malignant neoplasm of blood vessel malignant neoplasm of bursa malignant neoplasm of cartilage malignant neoplasm of fascia	Neoplasm of uncertain behavior of connective tissue of ear Neoplasm of uncertain behavior of connective tissue of eyelid Stromal tumors of uncertain behavior of digestive system

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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources