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C50.1 vs Z80.3

C50.1 (Malignant neoplasm of central portion of breast) compared with Z80.3 (Family history of malignant neoplasm of breast), from the official CMS tabular data. Z80.3 is the personal-history/screening code for the active disease C50.1 names. MedCoder-derived

Can these codes be reported together?

Review

Condition lifecycle relationship

Z80.3
Family history of malignant neoplasm of breast
↔
C50.1
Malignant neoplasm of central portion of breast

What we found

History or screening versus active disease.Z80.3 is the personal-history or screening code for the active disease C50.1 names.

Site match derived from the code’s own title against the CMS/CDC Table of Neoplasms. A personal-history code describes a condition that no longer exists and is no longer being treated, so it is not interchangeable with the active-disease code.

What to review

Report the history code when the condition no longer exists and is no longer treated; report the active-disease code while it is.

Guide: History codes (Z codes)Check these on a claim

Why it matters

A personal-history code describes a condition that no longer exists and is no longer being treated, so it is not interchangeable with the active-disease code for the same site.

Source / rule

CMS Table of Neoplasms (site match derived from the code title)

Side by side

C50.1Malignant neoplasm of central portion of breastZ80.3Family history of malignant neoplasm of breast
Billing statusNon-billable header

Report instead: C50.111, C50.112, C50.119, C50.121, C50.122

Billable
ClassificationC00-D49 — Neoplasms (C00-D49)Z00-Z99 — Factors Influencing Health Status and Contact with Health Services (Z00-Z99)
DefinitionMalignant neoplasm of central portion of breast is a non-billable ICD-10-CM category code (C50.1).Family history of malignant neoplasm of breast is a billable ICD-10-CM diagnosis code (Z80.3).
Includes
connective tissue of breast
Paget's disease of breast
Paget's disease of nipple
Conditions classifiable to C50.-
Excludes1
skin of breast (C44.501, C44.511, C44.521, C44.591)
—
Use additional code
code to identify estrogen, and other hormones and factors receptor status (Z17.-)
—
Code also—
any follow-up examination (Z08-Z09)

Notes are the code’s own tabular entry, quoted as published. A note that names the other code is the one the verdict above rests on.

Edit this comparisonCheck a whole claim

Derived from the official CMS ICD-10-CM tabular data (FY2026). A coding-rule comparison, not billing advice: payer-specific edits and medical-necessity policy are outside its scope. All data sources