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C50.1 ICD-10-CM Code: Malignant neoplasm of central portion of breast

Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.

Official Registry Overview & Definition

Malignant neoplasm of central portion of breast is a non-billable ICD-10-CM category code (C50.1). A more specific billable subcode must be selected for claims submission.

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for C50.1 in the official ICD-10-CM tabular list.

Includes

Conditions the official ICD-10-CM tabular list includes under this code.

  • connective tissue of breast
  • Paget's disease of breast
  • Paget's disease of nipple

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Use Additional Code

Supplementary codes the tabular list directs you to add.

  • Use additional code to identify estrogen, and other hormones and factors receptor status (Z17.-)

Neoplasm Table Sites (1)

Anatomical sites from the official ICD-10-CM Table of Neoplasms that map to this code, with the matching behavior column.

  • Neoplasm, neoplastic, breast (connective tissue) (glandular tissue) (soft parts), central portion — Malignant, Primary

Frequently Compared Codes

The official Excludes notes on C50.1 name these codes. Each comparison page covers when the two can — or must not — be reported together.

Change history

No changes recorded for this code — unchanged since the FY2016 baseline of the change ledger.

Verify Before Coding

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim.

Relationships & Classification

Official ICD-10-CM tabular notes on other codes that name C50.1 or its code family.

3 Excludes1 notes: C49 (via C50.-), C49.3 (via C50.-), D05 (via C50.-).

3 Code First instructions across 2 chapters: D75.81 (via C50.-), Z17 (via C50.-), Z79.81 (via C50.-).

1 Code Also instructions: D61.82 (via C50.-).

Contextual Map

Every relationship of C50.1 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Hierarchy

  • C00-D49 — Chapter 2: Neoplasms (C00-D49) (C00-D49) [Hierarchy]
  • C00-C75 — Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue [Hierarchy]

Referenced by Excludes1 notes

  • C49 — Malignant neoplasm of other connective and soft tissue [Excludes1](via C50.-): “malignant neoplasm of connective tissue of breast (C50.-)” · check together
  • C49.3 — Malignant neoplasm of connective and soft tissue of thorax [Excludes1](via C50.-): “malignant neoplasm of breast (C50.-)” · check together
  • D05 — Carcinoma in situ of breast [Excludes1](via C50.-): “Paget's disease of breast or nipple (C50.-)” · check together

Referenced by Code First instructions

  • D75.81 — Myelofibrosis [Code First](via C50.-): “malignant neoplasm of breast (C50.-)” · check together
  • Z17 — Estrogen, and other hormones and factors receptor status [Code First](via C50.-): “malignant neoplasm of breast (C50.-)” · check together
  • Z79.81 — Long term (current) use of agents affecting estrogen receptors and estrogen levels [Code First](via C50.-): “malignant neoplasm of breast (C50.-)” · check together

Referenced by Code Also instructions

  • D61.82 — Myelophthisis [Code Also](via C50.-): “malignant neoplasm of breast (C50.-)” · check together

Neoplasm sites

  • Neoplasm, neoplastic, breast (connective tissue) (glandular tissue) (soft parts), central portion — Neoplasm, neoplastic, breast (connective tissue) (glandular tissue) (soft parts), central portion — Malignant, Primary [Neoplasm table]: “Neoplasm, neoplastic, breast (connective tissue) (glandular tissue) (soft parts), central portion (Malignant, Primary)”

Nearest codes (40)

  • C50 — Malignant neoplasm of breast [Sibling]
  • C50.0 — Malignant neoplasm of nipple and areola [Sibling]
  • C50.01 — Malignant neoplasm of nipple and areola, female [Sibling]
  • C50.011 — Malignant neoplasm of nipple and areola, right female breast [Sibling]
  • C50.012 — Malignant neoplasm of nipple and areola, left female breast [Sibling]
  • C50.019 — Malignant neoplasm of nipple and areola, unspecified female breast [Sibling]
  • C50.02 — Malignant neoplasm of nipple and areola, male [Sibling]
  • C50.021 — Malignant neoplasm of nipple and areola, right male breast [Sibling]
  • and 32 more

Frequently Asked Questions (FAQ) & Clinical Guidance

Can C50.1 be billed directly?

No. C50.1 (Malignant neoplasm of central portion of breast) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to C50.1 in its code family, with their registry titles.

  • C50.019 — Malignant neoplasm of nipple and areola, unspecified female breast
  • C50.02 — Malignant neoplasm of nipple and areola, male
  • C50.021 — Malignant neoplasm of nipple and areola, right male breast
  • C50.022 — Malignant neoplasm of nipple and areola, left male breast
  • C50.029 — Malignant neoplasm of nipple and areola, unspecified male breast
  • C50.11 — Malignant neoplasm of central portion of breast, female
  • C50.111 — Malignant neoplasm of central portion of right female breast
  • C50.112 — Malignant neoplasm of central portion of left female breast
  • C50.119 — Malignant neoplasm of central portion of unspecified female breast
  • C50.12 — Malignant neoplasm of central portion of breast, male

View all codes in the C50 family