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D61.82 ICD-10-CM Code: Myelophthisis

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
3 inclusion terms · 5 Excludes1 · 1 Excludes2 · 3 code-also instructions
Risk adjustment
CMS-HCC V28: 1 category · CMS-HCC V22 category 46 · RxHCC V08 category 96

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 820 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH MCC (MDC 17)
  • MS-DRG 821 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITH CC (MDC 17)
  • MS-DRG 822 — LYMPHOMA AND LEUKEMIA WITH MAJOR O.R. PROCEDURES WITHOUT CC/MCC (MDC 17)
  • MS-DRG 823 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITH MCC (MDC 17)
  • MS-DRG 824 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITH CC (MDC 17)
  • MS-DRG 825 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH OTHER PROCEDURES WITHOUT CC/MCC (MDC 17)
  • MS-DRG 840 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH MCC (MDC 17)
  • MS-DRG 841 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITH CC (MDC 17)
  • MS-DRG 842 — LYMPHOMA AND NON-ACUTE LEUKEMIA WITHOUT CC/MCC (MDC 17)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Risk Adjustment (CMS-HCC)

Payment categories this diagnosis maps to under CMS-HCC V28, payment year 2026.

  • HCC 109 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias

Other models: CMS-HCC V22 HCC 46 · RxHCC V08 HCC 96

Risk scores depend on the enrollee's full accepted diagnosis set and segment; a category mapping alone does not determine payment.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for D61.82 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Notes without a marker are published on D61.82 itself; “inherited from” names the category or block whose note applies here.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Leukoerythroblastic anemia
  • Myelophthisic anemia
  • Panmyelophthisis

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Source: inherited from D61

Code Also

Additional codes that may be required to fully describe the encounter.

  • the underlying disorder, such as:
  • malignant neoplasm of breast (C50.-)
  • tuberculosis (A15.-)

Coder workflow for D61.82

MedCoder structured workflow — derived from this code’s own official record

Before you code D61.82

  1. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with D61.82. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support a condition named in D61.82’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewD47.1, D75.81, D47.4

Consider D61.82. Then review the Code Also note, and confirm the code is valid for the date of service in the Verify section.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).

Official instructions as workflow

  • Excludes1 — check before selecting D61.82(5 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with D61.82: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareD47.1, D75.81, D47.4

    See the official tabular notes · Guidelines I.A.12.a

  • Excludes2 — not part of D61.82(1 note)

    Coding workflow: The conditions named in this note are not included in D61.82. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareD70

    See the official tabular notes · Guidelines I.A.12.b

  • Code Also — related condition(3 notes)

    Coding workflow: Review the related condition when both are documented and the instruction applies. A Code Also note does not fix sequencing; the order follows the circumstances of the encounter.

    ReviewC50, A15

    See the official tabular notes · Guidelines I.A.17

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: Both the condition D61.82 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewD47.1, D75.81, D47.4

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Code Overview

Myelophthisis is a billable ICD-10-CM diagnosis code (D61.82).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (5)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Official Coding Guidelines

No excerpt in the ICD-10-CM Official Guidelines names this code specifically. Its chapter carries only this chapter-wide note:

Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)

Reserved for future guideline expansion

Decision Points

The directives on this code's own record, as a pre-claim checklist.

  1. 3 Code Also notes — a second code may apply; the guidelines leave its sequencing to the circumstances of the encounter. See the Code Also notes
  2. 5 Excludes1 entries — codes named there are generally not reported together with this code (Guidelines I.A.12.a). See the Excludes1 notes
  3. 1 Excludes2 entry — those conditions are not part of this code and may be reported additionally when documented. See the Excludes2 notes

Checklist rows are derived from this code's own official directives; the wording of each check is MedCoder editorial. The official notes themselves are in the sections each row links to.

Verify Before Coding

  • CC as a secondary diagnosis (FY2026). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name D61.82 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 4 Excludes1 notes across 3 chapters: D47.1 — Chronic myeloproliferative disease, D61.81 — Pancytopenia, D75.81 — Myelofibrosis, R71 — Abnormality of red blood cells (via D61.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 23 Code First instructions across 3 chapters: I21.A1 — Myocardial infarction type 2 (via D61.-), M90.5 — Osteonecrosis in diseases classified elsewhere (via D61.-), T36 — Poisoning by, adverse effect of and underdosing of systemic antibiotics (via D61.-), T36-T39 — Antibiotics & Anti-infectives (T36-T39) (via D61.-), T36-T50 — Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50) (via D61.-), T37 — Poisoning by, adverse effect of and underdosing of other systemic anti-infectives and antiparasitics (via D61.-), T38 — Poisoning by, adverse effect of and underdosing of hormones and their synthetic substitutes and antagonists, not elsewhere classified (via D61.-), T39 — Poisoning by, adverse effect of and underdosing of nonopioid analgesics, antipyretics and antirheumatics (via D61.-), T40 — Poisoning by, adverse effect of and underdosing of narcotics and psychodysleptics [hallucinogens] (via D61.-), T40-T41 — Analgesics & Antipyretics (T40-T41) (via D61.-), T41 — Poisoning by, adverse effect of and underdosing of anesthetics and therapeutic gases (via D61.-), T42 — Poisoning by, adverse effect of and underdosing of antiepileptic, sedative- hypnotic and antiparkinsonism drugs (via D61.-), T42-T43 — Anticonvulsants & Psychotropics (T42-T43) (via D61.-), T43 — Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified (via D61.-), T44 — Poisoning by, adverse effect of and underdosing of drugs primarily affecting the autonomic nervous system (via D61.-), T44-T46 — Cardiovascular & Gastrointestinal (T44-T46) (via D61.-), T45 — Poisoning by, adverse effect of and underdosing of primarily systemic and hematological agents, not elsewhere classified (via D61.-), T46 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the cardiovascular system (via D61.-), T47 — Poisoning by, adverse effect of and underdosing of agents primarily affecting the gastrointestinal system (via D61.-), T47-T50 — Hormones & Systemic Agents (T47-T50) (via D61.-), +3 more.

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: CC — Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 41 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 9 MS-DRGs: DRG 820 (MDC 17), DRG 821 (MDC 17), DRG 822 (MDC 17), DRG 823 (MDC 17), DRG 824 (MDC 17), DRG 825 (MDC 17), DRG 840 (MDC 17), DRG 841 (MDC 17), DRG 842 (MDC 17).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):BLD003 — Aplastic anemia (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as CC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

D60.0 — Chronic acquired pure red cell aplasia, D60.1 — Transient acquired pure red cell aplasia, D60.8 — Other acquired pure red cell aplasias, D60.9 — Acquired pure red cell aplasia, unspecified, D61.1 — Drug-induced aplastic anemia, D61.2 — Aplastic anemia due to other external agents, D61.3 — Idiopathic aplastic anemia, D61.810 — Antineoplastic chemotherapy induced pancytopenia, D61.811 — Other drug-induced pancytopenia, D61.818 — Other pancytopenia, D61.89 — Other specified aplastic anemias and other bone marrow failure syndromes, D61.9 — Aplastic anemia, unspecified, D62 — Acute posthemorrhagic anemia, D64.0 — Hereditary sideroblastic anemia, D64.2 — Secondary sideroblastic anemia due to drugs and toxins, D64.3 — Other sideroblastic anemias, D64.4 — Congenital dyserythropoietic anemia, D64.81 — Anemia due to antineoplastic chemotherapy, D64.89 — Other specified anemias, D64.9 — Anemia, unspecified, +20 more

Same CMS-HCC risk category (V28)

CMS maps these diagnoses to the same Hierarchical Condition Category (Acquired Hemolytic, Aplastic, and Sideroblastic Anemias) for risk-adjusted payment.

D60.0 — Chronic acquired pure red cell aplasia, D60.8 — Other acquired pure red cell aplasias, D60.9 — Acquired pure red cell aplasia, unspecified, D61.01 — Constitutional (pure) red blood cell aplasia, D61.02 — Shwachman-Diamond syndrome, D61.03 — Fanconi anemia, D61.09 — Other constitutional aplastic anemia, D61.2 — Aplastic anemia due to other external agents, D61.3 — Idiopathic aplastic anemia, D61.818 — Other pancytopenia, D61.89 — Other specified aplastic anemias and other bone marrow failure syndromes, D64.0 — Hereditary sideroblastic anemia, D64.1 — Secondary sideroblastic anemia due to disease, D64.3 — Other sideroblastic anemias, D64.4 — Congenital dyserythropoietic anemia, P55.0 — Rh isoimmunization of newborn, P55.1 — ABO isoimmunization of newborn, P55.8 — Other hemolytic diseases of newborn, P55.9 — Hemolytic disease of newborn, unspecified, P56.0 — Hydrops fetalis due to isoimmunization, +16 more

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Aplastic anemia).

D61.01 — Constitutional (pure) red blood cell aplasia, D61.02 — Shwachman-Diamond syndrome, D61.03 — Fanconi anemia, D61.09 — Other constitutional aplastic anemia, D61.1 — Drug-induced aplastic anemia, D61.2 — Aplastic anemia due to other external agents, D61.3 — Idiopathic aplastic anemia, D61.810 — Antineoplastic chemotherapy induced pancytopenia, D61.811 — Other drug-induced pancytopenia, D61.818 — Other pancytopenia, D61.89 — Other specified aplastic anemias and other bone marrow failure syndromes, D61.9 — Aplastic anemia, unspecified, D63.0 — Anemia in neoplastic disease, D63.1 — Anemia in chronic kidney disease, D63.8 — Anemia in other chronic diseases classified elsewhere, D64.0 — Hereditary sideroblastic anemia, D64.1 — Secondary sideroblastic anemia due to disease, D64.2 — Secondary sideroblastic anemia due to drugs and toxins, D64.3 — Other sideroblastic anemias, D64.4 — Congenital dyserythropoietic anemia, +7 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Anemia”; these codes share that main term but sit in a different category of the Tabular List.

D59.19 — Other autoimmune hemolytic anemia (Lederer's), D59.2 — Drug-induced nonautoimmune hemolytic anemia (hemolytic, due to, drugs), D59.4 — Other nonautoimmune hemolytic anemias (hemolytic, toxic), D59.6 — Hemoglobinuria due to hemolysis from other external causes (hemolytic, acquired, with hemoglobinuria NEC), D59.8 — Other acquired hemolytic anemias (hemolytic, acquired, specified type NEC), D59.9 — Acquired hemolytic anemia, unspecified (hemolytic, acute), D60.0 — Chronic acquired pure red cell aplasia (aplastic, red cell, chronic), D60.1 — Transient acquired pure red cell aplasia (aplastic, red cell, transient), D60.8 — Other acquired pure red cell aplasias (aplastic, red cell, specified type NEC), D60.9 — Acquired pure red cell aplasia, unspecified (pure red cell), D62 — Acute posthemorrhagic anemia (blood loss, acute), D63.0 — Anemia in neoplastic disease (in, neoplastic disease), D63.1 — Anemia in chronic kidney disease (in, failure, kidney), D63.8 — Anemia in other chronic diseases classified elsewhere (intertropical), D64.0 — Hereditary sideroblastic anemia (sideroblastic, hereditary), D64.1 — Secondary sideroblastic anemia due to disease (sideroblastic, secondary, disease), D64.2 — Secondary sideroblastic anemia due to drugs and toxins (sideroblastic, secondary, drugs and toxins), D64.3 — Other sideroblastic anemias (sideroblastic), D64.4 — Congenital dyserythropoietic anemia (dyshematopoietic), D64.81 — Anemia due to antineoplastic chemotherapy (due to, antineoplastic chemotherapy), +66 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Fecal Occult Blood Test (FOBT)

Contextual Map

Every relationship of D61.82 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run D61.82 with these 15 related codes in Claim Check

Hierarchy

Excludes1

Code Also

Referenced by Excludes1 notes

Referenced by Code First instructions (23)

Clinical classification (CCSR)

Risk adjustment (CMS-HCC)

  • HCC 109 — Acquired Hemolytic, Aplastic, and Sideroblastic Anemias [CMS-HCC]— CMS-HCC V28 · 2026

MS-DRG Grouper (9)

MDC crossing

  • MDC 17 — Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms[MDC crossing]: “Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 4,730 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries

  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), leukoerythroblastic[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), myelophthisic[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), normocytic (infectional), myelophthisic[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Myelophthisis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Panmyelophthisis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (16)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Coding guidelines Official source data
ICD-10-CM Official Guidelines for Coding and Reporting (FY2026), quoted by section Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Risk adjustment Official source data
2026 Mid-Year Final ICD-10 Mappings + Model Software (cms.gov/files/zip/2026-midyear-final-icd-10-mappings.zip, 2026-midyear-final-model-software.zip) — CMS-HCC V28, PY2026 mid-year final release Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "D61.82 — Myelophthisis." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/d61.82-myelophthisis

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Myelophthisis

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D61.82 in its code family, with their registry titles.

View all codes in the D61 family