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ICD-10/D64.81

D64.81 ICD-10-CM Code: Anemia due to antineoplastic chemotherapy

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Inpatient Payment Groups (MS-DRG)

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43.0 (FY2026), Appendix B.

  • MS-DRG 811 — RED BLOOD CELL DISORDERS WITH MCC (MDC 16)
  • MS-DRG 812 — RED BLOOD CELL DISORDERS WITHOUT MCC (MDC 16)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Code Set: Valid FY2026 and FY2027. FY2026 took effect October 1, 2025.

Official Registry Overview & Definition

Anemia due to antineoplastic chemotherapy is a billable ICD-10-CM diagnosis code (D64.81).

Official Tabular Instructional Notes

Sequencing, inclusion, and exclusion notes published for D64.81 in the official ICD-10-CM tabular list.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Antineoplastic chemotherapy induced anemia

Excludes1 — Not Coded Here

Conditions that can never be reported with this code; the two are mutually exclusive.

  • refractory anemia (D46.-)
  • refractory anemia with excess blasts in transformation RAEB T

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

  • anemia in neoplastic disease (D63.0)
  • aplastic anemia due to antineoplastic chemotherapy (D61.1)

Nearest Codes in This Family

Official ICD-10-CM classifications closest to D64.81 in its code family, with their registry titles.

  • D64 — Other anemias
  • D64.0 — Hereditary sideroblastic anemia
  • D64.1 — Secondary sideroblastic anemia due to disease
  • D64.2 — Secondary sideroblastic anemia due to drugs and toxins
  • D64.3 — Other sideroblastic anemias
  • D64.4 — Congenital dyserythropoietic anemia
  • D64.8 — Other specified anemias
  • D64.89 — Other specified anemias
  • D64.9 — Anemia, unspecified

View all codes in the D64 family

Indexed Clinical Terms (2)

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code.

  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), due to (in) (with), antineoplastic chemotherapy
  • Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound), due to (in) (with), chemotherapy, antineoplastic