C96.6 vs E88
C96.6 (Unifocal Langerhans-cell histiocytosis) compared with E88 (Other and unspecified metabolic disorders), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. E88 carries an Excludes1 note covering C96.6: “histiocytosis X (chronic) (C96.6)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| C96.6Unifocal Langerhans-cell histiocytosis | E88Other and unspecified metabolic disorders | |
|---|---|---|
| Billing status | Billable | Non-billable header |
| Classification | C00-D49 — Neoplasms (C00-D49) | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) |
| Definition | Unifocal Langerhans-cell histiocytosis is a billable ICD-10-CM diagnosis code (C96.6). | Other and unspecified metabolic disorders is a non-billable ICD-10-CM category code (E88). |
| Includes | Eosinophilic granuloma Histiocytosis X, unifocal Histiocytosis X NOS Langerhans-cell histiocytosis NOS | — |
| Use additional code | — | codes for associated conditions |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources