D21.2 vs D48.1

D21.2 (Benign neoplasm of connective and other soft tissue of lower limb, including hip) compared with D48.1 (Neoplasm of uncertain behavior of connective and other soft tissue), from the official CMS tabular data. D21.2 and D48.1 name the same anatomical site (aponeurosis) with a different neoplasm behavior. MedCoder-derived

Relationship

Informational

Neoplasm table relationship

D48.1

Neoplasm of uncertain behavior of connective and other soft tissue

↔

D21.2

Benign neoplasm of connective and other soft tissue of lower limb, including hip

Same anatomical site, different neoplasm behavior.

Same site — benign neoplasm (aponeurosis)

The behavior documented for the site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column of the neoplasm table, and therefore which code, applies.

Source: CMS Table of Neoplasms

Can these codes be reported together?

Same site, different neoplasm behavior. D48.1 and D21.2 name the same anatomical site (aponeurosis) with a different neoplasm behavior.

From the CMS/CDC Table of Neoplasms: the behavior documented for that site — malignant primary, secondary, carcinoma in situ, benign, uncertain or unspecified — decides which column, and therefore which code, applies.

Side by side

	D21.2Benign neoplasm of connective and other soft tissue of lower limb, including hip	D48.1Neoplasm of uncertain behavior of connective and other soft tissue
Billing status	Non-billable header Report instead: D21.20, D21.21, D21.22	Non-billable header Report instead: D48.110, D48.111, D48.112, D48.113, D48.114
Classification	C00-D49 — Neoplasms (C00-D49)	C00-D49 — Neoplasms (C00-D49)
Definition	Benign neoplasm of connective and other soft tissue of lower limb, including hip is a non-billable ICD-10-CM category code (D21.2).	Neoplasm of uncertain behavior of connective and other soft tissue is a non-billable ICD-10-CM category code (D48.1).
Includes	benign neoplasm of blood vessel benign neoplasm of bursa benign neoplasm of cartilage benign neoplasm of fascia	Neoplasm of uncertain behavior of connective tissue of ear Neoplasm of uncertain behavior of connective tissue of eyelid Stromal tumors of uncertain behavior of digestive system

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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources