D55 vs E86
D55 (Anemia due to enzyme disorders) compared with E86 (Volume depletion), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. E86 carries an Excludes1 note covering D55: “hemolytic anemias attributable to enzyme disorders (D55.-)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| D55Anemia due to enzyme disorders | E86Volume depletion | |
|---|---|---|
| Billing status | Non-billable header | Non-billable header |
| Classification | D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) |
| Definition | Anemia due to enzyme disorders is a non-billable ICD-10-CM category code (D55). | Volume depletion is a non-billable ICD-10-CM category code (E86). |
| Use additional code | — | code(s) for any associated disorders of electrolyte and acid-base balance (E87.-) |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources