D68.5 vs M31.19
D68.5 (Primary thrombophilia) compared with M31.19 (Other thrombotic microangiopathy), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. D68.5 carries an Excludes1 note covering M31.19: “thrombotic thrombocytopenic purpura (M31.19)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| D68.5Primary thrombophilia | M31.19Other thrombotic microangiopathy | |
|---|---|---|
| Billing status | Non-billable header | Billable |
| Classification | D50-D89 — Diseases of the Blood and Blood-forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89) | M00-M99 — Diseases of the Musculoskeletal System and Connective Tissue (M00-M99) |
| Definition | Primary thrombophilia is a non-billable ICD-10-CM category code (D68.5). | Other thrombotic microangiopathy is a billable ICD-10-CM diagnosis code (M31.19). |
| Includes | Primary hypercoagulable states | autoimmune disease NOS collagen (vascular) disease NOS systemic autoimmune disease systemic collagen (vascular) disease |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources