E65 vs R22
E65 (Localized adiposity) compared with R22 (Localized swelling, mass and lump of skin and subcutaneous tissue), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. R22 carries an Excludes1 note covering E65: “localized adiposity (E65)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| E65Localized adiposity | R22Localized swelling, mass and lump of skin and subcutaneous tissue | |
|---|---|---|
| Billing status | Billable | Non-billable header |
| Classification | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) | R00-R99 — Symptoms, Signs and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99) |
| Definition | Localized adiposity is a billable ICD-10-CM diagnosis code (E65). | Localized swelling, mass and lump of skin and subcutaneous tissue is a non-billable ICD-10-CM category code (R22). |
| Includes | Fat pad | subcutaneous nodules (localized)(superficial) |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources