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E65 ICD-10-CM Code: Localized adiposity

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
1 inclusion term

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v43, Appendix B.

  • MS-DRG 640 — MISCELLANEOUS DISORDERS OF NUTRITION, METABOLISM, FLUIDS AND ELECTROLYTES WITH MCC (MDC 10)
  • MS-DRG 641 — MISCELLANEOUS DISORDERS OF NUTRITION, METABOLISM, FLUIDS AND ELECTROLYTES WITHOUT MCC (MDC 10)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for E65 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Fat pad

Code Overview

Localized adiposity is a billable ICD-10-CM diagnosis code (E65).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (9)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name E65 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Excludes1 note: R22 — Localized swelling, mass and lump of skin and subcutaneous tissue.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

MS-DRG Grouper Relationships (FY2026)

Potential MS-DRG participation — not a DRG assignment.

FY2026 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 2 MS-DRGs: DRG 640 (MDC 10), DRG 641 (MDC 10).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):END016 — Other specified and unspecified nutritional and metabolic disorders (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other specified and unspecified nutritional and metabolic disorders).

D81.3 — Adenosine deaminase [ADA] deficiency, D81.30 — Adenosine deaminase deficiency, unspecified, D81.31 — Severe combined immunodeficiency due to adenosine deaminase deficiency, D81.32 — Adenosine deaminase 2 deficiency, D81.39 — Other adenosine deaminase deficiency, D81.5 — Purine nucleoside phosphorylase [PNP] deficiency, D81.810 — Biotinidase deficiency, D81.818 — Other biotin-dependent carboxylase deficiency, D81.819 — Biotin-dependent carboxylase deficiency, unspecified, E66.3 — Overweight, E67.0 — Hypervitaminosis A, E67.1 — Hypercarotenemia, E67.2 — Megavitamin-B6 syndrome, E67.3 — Hypervitaminosis D, E67.8 — Other specified hyperalimentation, E70.0 — Classical phenylketonuria, E70.1 — Other hyperphenylalaninemias, E70.20 — Disorder of tyrosine metabolism, unspecified, E70.21 — Tyrosinemia, E70.29 — Other disorders of tyrosine metabolism, +258 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Excess, excessive, excessively”, “Hypertrophy, hypertrophic”, “Pannus”; these codes share that main term but sit in a different category of the Tabular List.

A71.1 — Active stage of trachoma (trachomatosus, trachomatous), E16.3 — Increased secretion of glucagon (glucagon), E21.0 — Primary hyperparathyroidism (parathyroid), E23.6 — Other disorders of pituitary gland (pituitary), E27.8 — Other specified disorders of adrenal gland (adrenal cortex), E28.0 — Estrogen excess (estrogen), E28.1 — Androgen excess (androgen), E32.0 — Persistent hyperplasia of thymus (thymic, thymus), E67.0 — Hypervitaminosis A (vitamin, A), E67.1 — Hypercarotenemia (carotene, carotin), E67.3 — Hypervitaminosis D (vitamin, D), E87.0 — Hyperosmolality and hypernatremia (sodium), E87.5 — Hyperkalemia (kalium), F10.10 — Alcohol abuse, uncomplicated (drinking), F10.20 — Alcohol dependence, uncomplicated (drinking, habitual), F52.8 — Other sexual dysfunction not due to a substance or known physiological condition (sexual drive), G71.09 — Other specified muscular dystrophies (pseudomuscular), G93.89 — Other specified disorders of brain (brain), H11.89 — Other specified disorders of conjunctiva (conjunctiva, lymphoid), H16.42 — Pannus (corneal), +145 more

Contextual Map

Every relationship of E65 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run E65 with this related code in Claim Check

Hierarchy

Referenced by Excludes1 notes

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 10 — Endocrine, Nutritional and Metabolic Diseases and Disorders[MDC crossing]: “Endocrine, Nutritional and Metabolic Diseases and Disorders — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 5,008 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2026

Index entries (9)

  • Adiposity, localized[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Excess, excessive, excessively, fat, localized[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Fat, localized (pad)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Fat, pad[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Fatty, apron[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Hypertrophy, hypertrophic, fat pad[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Panniculus adiposus (abdominal)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Pannus (allergic) (cornea) (degenerativus) (keratic), abdominal (symptomatic)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • and 1 more

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v43 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "E65 — Localized adiposity." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/e65-localized-adiposity

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Localized adiposity

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.