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E16.3 ICD-10-CM Code: Increased secretion of glucagon

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Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
1 inclusion term
Risk adjustment
RxHCC V08 category 66

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too; the Instructions section marks which is which.

IncludesWhat this code covers
  • Hyperplasia of pancreatic endocrine cells with glucagon excess

CompareCheck ClaimView Related Codes

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 643 — ENDOCRINE DISORDERS WITH MCC (MDC 10)
  • MS-DRG 644 — ENDOCRINE DISORDERS WITH CC (MDC 10)
  • MS-DRG 645 — ENDOCRINE DISORDERS WITHOUT CC/MCC (MDC 10)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for E16.3 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Hyperplasia of pancreatic endocrine cells with glucagon excess

Don’t confuse E16.3 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of E16.3 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • E16.2— Specificity relationship (Review)

    Overlapping diagnoses in the same category.

    Overlapping codes in the same category — the documentation decides which is the more specific fit.

    What moves you there: A record that documents no more than “Hypoglycemia, unspecified” takes E16.2; specificity in the record moves it back here.

    Full comparison: E16.3 vs E16.2 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Increased secretion of glucagon is a billable ICD-10-CM diagnosis code (E16.3).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name E16.3 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Excludes1 note: E74 — Other disorders of carbohydrate metabolism.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 1 Code First instruction: G63 — Polyneuropathy in diseases classified elsewhere (via E16.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 3 MS-DRGs: DRG 643 (MDC 10), DRG 644 (MDC 10), DRG 645 (MDC 10).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):END015 — Other specified and unspecified endocrine disorders (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other specified and unspecified endocrine disorders).

A18.7 — Tuberculosis of adrenal glands, A18.82 — Tuberculosis of other endocrine glands, A39.1 — Waterhouse-Friderichsen syndrome, E15 — Nondiabetic hypoglycemic coma, E16.0 — Drug-induced hypoglycemia without coma, E16.1 — Other hypoglycemia, E16.2 — Hypoglycemia, unspecified, E16.4 — Increased secretion of gastrin, E16.8 — Other specified disorders of pancreatic internal secretion, E16.9 — Disorder of pancreatic internal secretion, unspecified, E16.A1 — Hypoglycemia level 1, E16.A2 — Hypoglycemia level 2, E16.A3 — Hypoglycemia level 3, E20.0 — Idiopathic hypoparathyroidism, E20.1 — Pseudohypoparathyroidism, E20.8 — Other hypoparathyroidism, E20.810 — Autosomal dominant hypocalcemia, E20.811 — Secondary hypoparathyroidism in diseases classified elsewhere, E20.812 — Autoimmune hypoparathyroidism, E20.818 — Other specified hypoparathyroidism due to impaired parathyroid hormone secretion, +83 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Hyperplasia, hyperplastic”, “Hypersecretion”, “Increase, increased”, …; these codes share that main term but sit in a different category of the Tabular List.

D61.818 — Other pancytopenia (chemistry, blood, pancytopenia), D68.9 — Coagulation defect, unspecified (coagulation), D72.89 — Other specified disorders of white blood cells (white blood cells, specified NEC), D72.9 — Disorder of white blood cells, unspecified (leukocyte NEC), D73.1 — Hypersplenism (splenic activity), D75.89 — Other specified diseases of blood and blood-forming organs (erythroid), E05.80 — Other thyrotoxicosis without thyrotoxic crisis or storm (hormone, thyroid stimulating), E05.81 — Other thyrotoxicosis with thyrotoxic crisis or storm (hormone, thyroid stimulating, with thyroid storm), E07.0 — Hypersecretion of calcitonin (calcitonin), E07.89 — Other specified disorders of thyroid (thyroid-binding globulin), E21.0 — Primary hyperparathyroidism (parathyroid), E22.0 — Acromegaly and pituitary gigantism (hormone, growth), E22.2 — Syndrome of inappropriate secretion of antidiuretic hormone (hormone, antidiuretic), E22.9 — Hyperfunction of pituitary gland, unspecified (hormone, pituitary), E24.0 — Pituitary-dependent Cushing's disease (ACTH, pituitary), E24.9 — Cushing's syndrome, unspecified (cortisol), E25.0 — Congenital adrenogenital disorders associated with enzyme deficiency (adrenal, congenital), E25.9 — Adrenogenital disorder, unspecified (adrenal, with, virilization), E27.0 — Other adrenocortical overactivity (ACTH), E27.5 — Adrenomedullary hyperfunction (adrenaline), +358 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

HbA1c Test (Glycated Hemoglobin), Blood Glucose Test

Contextual Map

Every relationship of E16.3 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run E16.3 with these 2 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Code First instructions

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 10 — Endocrine, Nutritional and Metabolic Diseases and Disorders[MDC crossing]: “Endocrine, Nutritional and Metabolic Diseases and Disorders — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 5,013 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries

  • Abnormal, abnormality, abnormalities, glucagon secretion[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Abnormal, abnormality, abnormalities, secretion, glucagon[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Excess, excessive, excessively, glucagon[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Hyperplasia, hyperplastic, pancreatic islet cells, alpha, with excess, glucagon[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Hypersecretion, glucagon[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Increase, increased, secretion, glucagon[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027

Nearest codes (11)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Indexed Clinical Terms (6)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 20, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "E16.3 — Increased secretion of glucagon." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/e16.3-increased-secretion-of-glucagon

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Increased secretion of glucagon

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to E16.3 in its code family, with their registry titles.

View all codes in the E16 family