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E16.4 ICD-10-CM Code: Increased secretion of gastrin

Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Coding at a Glance

Tabular directives
3 inclusion terms
Risk adjustment
RxHCC V08 category 66

Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 380 — COMPLICATED PEPTIC ULCER WITH MCC (MDC 06)
  • MS-DRG 381 — COMPLICATED PEPTIC ULCER WITH CC (MDC 06)
  • MS-DRG 382 — COMPLICATED PEPTIC ULCER WITHOUT CC/MCC (MDC 06)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for E16.4 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Hypergastrinemia
  • Hyperplasia of pancreatic endocrine cells with gastrin excess
  • Zollinger-Ellison syndrome

Code Overview

Increased secretion of gastrin is a billable ICD-10-CM diagnosis code (E16.4).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Indexed Clinical Terms (8)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Verify Before Coding

  • No Medicare Code Editor or MS-DRG Definitions Manual restrictions apply to this code.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder structured relationships — computed from published CMS and AHRQ datasets

Other codes that name E16.4 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Excludes1 note: K29 — Gastritis and duodenitis.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 1 Code First instruction: G63 — Polyneuropathy in diseases classified elsewhere (via E16.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: not on the CMS CC/MCC list — as a secondary diagnosis this code does not change MS-DRG severity for that release.

Named in the grouper logic of 3 MS-DRGs: DRG 380 (MDC 06), DRG 381 (MDC 06), DRG 382 (MDC 06).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):END015 — Other specified and unspecified endocrine disorders (default).

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical category (Other specified and unspecified endocrine disorders).

A18.7 — Tuberculosis of adrenal glands, A18.82 — Tuberculosis of other endocrine glands, A39.1 — Waterhouse-Friderichsen syndrome, E15 — Nondiabetic hypoglycemic coma, E16.0 — Drug-induced hypoglycemia without coma, E16.1 — Other hypoglycemia, E16.2 — Hypoglycemia, unspecified, E16.3 — Increased secretion of glucagon, E16.8 — Other specified disorders of pancreatic internal secretion, E16.9 — Disorder of pancreatic internal secretion, unspecified, E16.A1 — Hypoglycemia level 1, E16.A2 — Hypoglycemia level 2, E16.A3 — Hypoglycemia level 3, E20.0 — Idiopathic hypoparathyroidism, E20.1 — Pseudohypoparathyroidism, E20.8 — Other hypoparathyroidism, E20.810 — Autosomal dominant hypocalcemia, E20.811 — Secondary hypoparathyroidism in diseases classified elsewhere, E20.812 — Autoimmune hypoparathyroidism, E20.818 — Other specified hypoparathyroidism due to impaired parathyroid hormone secretion, +83 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main terms “Hyperplasia, hyperplastic”, “Hypersecretion”, “Increase, increased”, …; these codes share that main term but sit in a different category of the Tabular List.

D61.818 — Other pancytopenia (chemistry, blood, pancytopenia), D68.9 — Coagulation defect, unspecified (coagulation), D72.89 — Other specified disorders of white blood cells (white blood cells, specified NEC), D72.9 — Disorder of white blood cells, unspecified (leukocyte NEC), D73.1 — Hypersplenism (splenic activity), D75.89 — Other specified diseases of blood and blood-forming organs (erythroid), E05.80 — Other thyrotoxicosis without thyrotoxic crisis or storm (hormone, thyroid stimulating), E05.81 — Other thyrotoxicosis with thyrotoxic crisis or storm (hormone, thyroid stimulating, with thyroid storm), E07.0 — Hypersecretion of calcitonin (calcitonin), E07.89 — Other specified disorders of thyroid (thyroid-binding globulin), E21.0 — Primary hyperparathyroidism (parathyroid), E22.0 — Acromegaly and pituitary gigantism (hormone, growth), E22.2 — Syndrome of inappropriate secretion of antidiuretic hormone (hormone, antidiuretic), E22.9 — Hyperfunction of pituitary gland, unspecified (hormone, pituitary), E24.0 — Pituitary-dependent Cushing's disease (ACTH, pituitary), E24.9 — Cushing's syndrome, unspecified (cortisol), E25.0 — Congenital adrenogenital disorders associated with enzyme deficiency (adrenal, congenital), E25.9 — Adrenogenital disorder, unspecified (adrenal, with, virilization), E27.0 — Other adrenocortical overactivity (ACTH), E27.5 — Adrenomedullary hyperfunction (adrenaline), +321 more

Lab tests where this diagnosis supports Medicare coverage (NCD)

Medicare's National Coverage Determination (NCD) program lists this diagnosis as medical justification for these lab tests.

Blood Glucose Test

Contextual Map

Every relationship of E16.4 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run E16.4 with these 2 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Code First instructions

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 06 — Diseases and Disorders of the Digestive System[MDC crossing]: “Diseases and Disorders of the Digestive System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 5,748 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries

  • Abnormal, abnormality, abnormalities, gastrin secretion[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Abnormal, abnormality, abnormalities, secretion, gastrin[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Ellison-Zollinger syndrome[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Hypergastrinemia[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Hyperplasia, hyperplastic, pancreatic islet cells, alpha, with excess, gastrin[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Hypersecretion, gastrin[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Increase, increased, secretion, gastrin[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026
  • Zollinger-Ellison syndrome[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2026

Nearest codes (11)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder structured relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "E16.4 — Increased secretion of gastrin." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/e16.4-increased-secretion-of-gastrin

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Increased secretion of gastrin

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to E16.4 in its code family, with their registry titles.

View all codes in the E16 family