E75.3 vs E78
E75.3 (Sphingolipidosis, unspecified) compared with E78 (Disorders of lipoprotein metabolism and other lipidemias), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.
Can these codes be reported together?
No — do not report together. E78 carries an Excludes1 note covering E75.3: “sphingolipidosis (E75.0-E75.3)”
Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
Side by side
| E75.3Sphingolipidosis, unspecified | E78Disorders of lipoprotein metabolism and other lipidemias | |
|---|---|---|
| Billing status | Billable | Non-billable header |
| Classification | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) | E00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89) |
| Definition | Sphingolipidosis, unspecified is a billable ICD-10-CM diagnosis code (E75.3). | Disorders of lipoprotein metabolism and other lipidemias is a non-billable ICD-10-CM category code (E78). |
Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources