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Compare/E78 vs R74

E78 vs R74

E78 (Disorders of lipoprotein metabolism and other lipidemias) compared with R74 (Abnormal serum enzyme levels), from the official CMS tabular data. Both may be reported when both conditions are documented (Excludes2).

Can these codes be reported together?

Yes, when both are documented. R74 carries an Excludes2 note covering E78: “abnormalities of lipids (E78.-)”

Excludes2 marks distinct conditions — both may be reported when both are documented.

Side by side

E78Disorders of lipoprotein metabolism and other lipidemiasR74Abnormal serum enzyme levels
Billing statusNon-billable header

Report instead: E78.00, E78.010, E78.011, E78.019, E78.1

Non-billable header

Report instead: R74.01, R74.02, R74.8, R74.9

ClassificationE00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89)R00-R99 — Symptoms, Signs and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99)
DefinitionDisorders of lipoprotein metabolism and other lipidemias is a non-billable ICD-10-CM category code (E78).Abnormal serum enzyme levels is a non-billable ICD-10-CM category code (R74).
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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources