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Compare/E85 vs M61

E85 vs M61

E85 (Amyloidosis) compared with M61 (Calcification and ossification of muscle), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Can these codes be reported together?

No — do not report together. M61 carries an Excludes1 note covering E85: “myopathy in amyloidosis (E85.-)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Side by side

E85AmyloidosisM61Calcification and ossification of muscle
Billing statusNon-billable header

Report instead: E85.0, E85.1, E85.2, E85.3, E85.4

Non-billable header

Report instead: M61.00, M61.011, M61.012, M61.019, M61.021

ClassificationE00-E89 — Endocrine, Nutritional and Metabolic Diseases (E00-E89)M00-M99 — Diseases of the Musculoskeletal System and Connective Tissue (M00-M99)
DefinitionAmyloidosis is a non-billable ICD-10-CM category code (E85).Calcification and ossification of muscle is a non-billable ICD-10-CM category code (M61).
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Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources