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Compare/L87.1 vs M35

L87.1 vs M35

L87.1 (Reactive perforating collagenosis) compared with M35 (Other systemic involvement of connective tissue), from the official CMS tabular data. Do not report these codes together: the official tabular list marks them Excludes1.

Can these codes be reported together?

No — do not report together. M35 carries an Excludes1 note covering L87.1: “reactive perforating collagenosis (L87.1)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Side by side

L87.1Reactive perforating collagenosisM35Other systemic involvement of connective tissue
Billing statusBillableNon-billable header

Report instead: M35.00, M35.01, M35.02, M35.03, M35.04

ClassificationL00-L99 — Diseases of the Skin and Subcutaneous Tissue (L00-L99)M00-M99 — Diseases of the Musculoskeletal System and Connective Tissue (M00-M99)
DefinitionReactive perforating collagenosis is a billable ICD-10-CM diagnosis code (L87.1).Other systemic involvement of connective tissue is a non-billable ICD-10-CM category code (M35).
Includes
autoimmune disease NOS
collagen (vascular) disease NOS
systemic autoimmune disease
systemic collagen (vascular) disease

Derived from the official CMS ICD-10-CM tabular data (FY2026). Not billing advice; verify sequencing rules for the encounter. All data sources