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R85.613 vs R85.82

R85.613 (High grade squamous intraepithelial lesion on cytologic smear of anus (HGSIL)) compared with R85.82 (Anal low risk human papillomavirus (HPV) DNA test positive), from the official CMS tabular data.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Summary

These codes can be reported together when both conditions are documented, because R85.613 lists R85.82 under Excludes2, which marks them as distinct conditions.

Official rule
What is different?

The conditions named.R85.613 is “High grade squamous intraepithelial lesion on cytologic smear of anus (HGSIL)”; R85.82 is “Anal low risk human papillomavirus (HPV) DNA test positive”.

Registry fact

Can these codes be reported together?

Yes, when both are documented.R85.613 lists R85.82 under Excludes2: “anal low risk human papillomavirus (HPV) DNA test positive (R85.82)”. Excludes2 marks distinct conditions that may both be reported when both are documented.

Official ruleGuide: Excludes1 vs Excludes2

Is there an Excludes2 relationship?

Yes.R85.613’s tabular entry: “anal low risk human papillomavirus (HPV) DNA test positive (R85.82)”. The note covers R85.82.

Official ruleGuide: Excludes1 vs Excludes2

Nothing found in 5 other checks
Is there an Excludes1 relationship?

None.Neither entry carries an Excludes1 note that names the other code. R85.613 carries 11 Excludes1 notes and R85.82 carries 4 Excludes1 notes covering other codes; the side-by-side table quotes them.

Official rule

Is one more specific?

No.Neither is a subdivision of the other, and neither title is the unspecified form; they describe different conditions within category R85.

Registry fact

Is one a parent or header code?

No.Both are billable codes, and neither contains the other.

Registry fact

Are there sequencing instructions?

None.Neither entry carries a Code First or Use Additional Code note that names the other.

Official rule

Are there other coding relationships?

None found.No laterality, encounter-phase, Table of Neoplasms, Table of Drugs and Chemicals, or history-versus-active-disease relationship links these codes.

MedCoder-derived

Official rule: a tabular instructional note or a section of the ICD-10-CM Official Guidelines, quoted as published. Registry fact: the codes’ own published attributes (titles, billable status, position in the hierarchy, code set). MedCoder-derived: a reading MedCoder computes from those facts; it is not itself a rule. How to read the labels

Can these codes be reported together?

Informational

Excludes2 relationship

R85.613
High grade squamous intraepithelial lesion on cytologic smear of anus (HGSIL)
↔
R85.82
Anal low risk human papillomavirus (HPV) DNA test positive

What we found

Yes, when both are documented.R85.613 carries an Excludes2 note covering R85.82: “anal low risk human papillomavirus (HPV) DNA test positive (R85.82)”

Excludes2 marks distinct conditions — both may be reported when both are documented.

What to review

Report both only when the documentation supports both conditions; otherwise report the one documented.

Guide: Excludes1 vs Excludes2Check these on a claim

Why it matters

An Excludes2 note means the excluded condition is not part of the code above it, but a patient can have both. Report both when both are documented.

Source / rule

CMS ICD-10-CM tabular instructional notes

Official guidance behind these answers

  • Section I.A.12.b — Excludes2 · applies to: Excludes2

    A type 2 Excludes note represents “Not included here.” An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.

    ICD-10-CM Official Guidelines FY2027

Quoted from the ICD-10-CM Official Guidelines for Coding and Reporting in effect for the release shown. The tabular notes above are the code-level instruction; these sections are the convention that says how such a note is applied. Source document (CMS PDF) · Release and checksum

Side by side

Similar descriptions do not make codes interchangeable. The documentation and the official instructions decide which code applies.

Official descriptionDiffers
R85.613

High grade squamous intraepithelial lesion on cytologic smear of anus (HGSIL)

R85.82

Anal low risk human papillomavirus (HPV) DNA test positive

StatusSame for both
Billable
Excludes1Differs
Only at R85.613
  • abnormal cytological findings in specimens from other digestive organs and abdominal cavity (R85.69)
  • carcinoma in situ of anus (histologically confirmed) (D01.3)
  • anal intraepithelial neoplasia I [AIN I] (K62.82)
  • anal intraepithelial neoplasia II [AIN II] (K62.82)
  • anal intraepithelial neoplasia III [AIN III] (D01.3)
  • dysplasia (mild) (moderate) of anus (histologically confirmed) (K62.82)
  • severe dysplasia of anus (histologically confirmed) (D01.3)
Only at R85.82

No note of its own beyond the shared notes

Shared by both codes (4 notes)
  • cloudy peritoneal dialysis effluent (R88.0)
  • fecal abnormalities (R19.5)
  • abnormal findings on antenatal screening of mother (O28.-)
  • diagnostic abnormal findings classified elsewhere - see Alphabetical Index
Excludes2Differs
Only at R85.613
  • anal high risk human papillomavirus (HPV) DNA test positive (R85.81)
  • anal low risk human papillomavirus (HPV) DNA test positive (R85.82)
Only at R85.82

No note of its own beyond the shared notes

Shared by both codes (3 notes)
  • abnormal findings on examination of blood, without diagnosis (R70-R79)
  • abnormal findings on examination of urine, without diagnosis (R80-R82)
  • abnormal tumor markers (R97.-)
Use additional codeDiffers
R85.613

None at this code

R85.82
  • code for associated human papillomavirus (B97.7)
CategorySame for both

R85 Abnormal findings in specimens from digestive organs and abdominal cavity

ChapterSame for both

R00-R99 — Symptoms, Signs and Abnormal Clinical and Laboratory Findings, Not Elsewhere Classified (R00-R99)

IncludesSame for both
  • abnormal findings in peritoneal fluid
  • abnormal findings in saliva

No Code first, Code also and 7th character note at either code.

Notes are the code’s own tabular entry, quoted as published. A note that names the other code is the one the verdict above rests on. In a row that differs, each code’s own notes are listed under it, and the notes every code shares are listed once beneath them.

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Derived from the official CMS ICD-10-CM tabular data (FY2027). A coding-rule comparison, not billing advice: payer-specific edits and medical-necessity policy are outside its scope. All data sources