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T43.625A vs T50.5

T43.625A (Adverse effect of amphetamines, initial encounter) compared with T50.5 (Poisoning by, adverse effect of and underdosing of appetite depressants), from the official CMS tabular data.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Summary

These codes can be reported together when both conditions are documented, because T43.625A lists T50.5 under Excludes2, which marks them as distinct conditions.

Official rule
What is different?

The conditions named and billing status.T43.625A is “Adverse effect of amphetamines, initial encounter”; T50.5 is “Poisoning by, adverse effect of and underdosing of appetite depressants”. T50.5 is a non-billable header; T43.625A is billable.

Registry fact

Can these codes be reported together?

Yes, when both are documented.T43.625A lists T50.5 under Excludes2: “appetite depressants (T50.5-)”. Excludes2 marks distinct conditions that may both be reported when both are documented.

Official ruleGuide: Excludes1 vs Excludes2

Is there an Excludes1 relationship?

None.Neither entry carries an Excludes1 note that names the other code. T43.625A carries 2 Excludes1 notes and T50.5 carries 1 Excludes1 note covering other codes; the side-by-side table quotes them.

Official rule

Is there an Excludes2 relationship?

Yes.T43.625A’s tabular entry: “appetite depressants (T50.5-)”. The note covers T50.5.

Official ruleGuide: Excludes1 vs Excludes2

Is one more specific?

Not comparable.The codes sit in different categories; specificity is only comparable within one category.

Is one a parent or header code?

One is a header.T50.5 is a non-billable header, but T43.625A is not one of its subdivisions.

Registry fact

Are there sequencing instructions?

None.Neither entry carries a Code First or Use Additional Code note that names the other.

Official rule

Are there other coding relationships?

None found.No laterality, encounter-phase, Table of Neoplasms, Table of Drugs and Chemicals, or history-versus-active-disease relationship links these codes.

MedCoder-derived

Official rule: a tabular instructional note or a section of the ICD-10-CM Official Guidelines, quoted as published. Registry fact: the codes’ own published attributes (titles, billable status, position in the hierarchy, code set). MedCoder-derived: a reading MedCoder computes from those facts; it is not itself a rule. How to read the labels

Can these codes be reported together?

Informational

Excludes2 relationship

T43.625A
Adverse effect of amphetamines, initial encounter
↔
T50.5
Poisoning by, adverse effect of and underdosing of appetite depressants

What we found

Yes, when both are documented.T43.625A carries an Excludes2 note covering T50.5: “appetite depressants (T50.5-)”

Excludes2 marks distinct conditions — both may be reported when both are documented.

What to review

Report both only when the documentation supports both conditions; otherwise report the one documented.

Guide: Excludes1 vs Excludes2Check these on a claim

Why it matters

An Excludes2 note means the excluded condition is not part of the code above it, but a patient can have both. Report both when both are documented.

Source / rule

CMS ICD-10-CM tabular instructional notes

Official guidance behind these answers

  • Section I.A.12.b — Excludes2 · applies to: Excludes2

    A type 2 Excludes note represents “Not included here.” An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.

    ICD-10-CM Official Guidelines FY2027

Quoted from the ICD-10-CM Official Guidelines for Coding and Reporting in effect for the release shown. The tabular notes above are the code-level instruction; these sections are the convention that says how such a note is applied. Source document (CMS PDF) · Release and checksum

Side by side

Similar descriptions do not make codes interchangeable. The documentation and the official instructions decide which code applies.

Official descriptionDiffers
T43.625A

Adverse effect of amphetamines, initial encounter

T50.5

Poisoning by, adverse effect of and underdosing of appetite depressants

StatusDiffers
T43.625A
Billable
T50.5
Non-billable header

A header is not reported on a claim; a code beneath it is.

Report instead: T50.5X1A, T50.5X1D, T50.5X1S, T50.5X2A, T50.5X2D

Excludes1Differs
T43.625A
  • poisoning by, adverse effect of and underdosing of cocaine (T40.5-)
  • toxic reaction to local anesthesia in pregnancy (O29.3-)
T50.5
  • toxic reaction to local anesthesia in pregnancy (O29.3-)
Excludes2Differs
T43.625A
  • appetite depressants (T50.5-)
  • barbiturates (T42.3-)
  • benzodiazepines (T42.4-)
  • drug dependence and related mental and behavioral disorders due to psychoactive substance use (F10.- -F19.-)
  • methaqualone (T42.6-)
  • psychodysleptics [hallucinogens] (T40.7-T40.9-)
  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
T50.5
  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)
Code firstSame for both
  • , for adverse effects, the nature of the adverse effect, such as:
  • adverse effect NOS (T88.7)
Use additional codeSame for both
  • code(s) to specify:
  • manifestations of poisoning
  • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
CategoryDiffers
T43.625A

T43 Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified

T50.5

T50 Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances

ChapterSame for both

S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)

IncludesSame for both
  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
7th characterDiffers
T43.625A
  • The appropriate 7th character is to be added to each code from category T43
T50.5
  • The appropriate 7th character is to be added to each code from category T50

No Code also note at either code.

Notes are the code’s own tabular entry, quoted as published. A note that names the other code is the one the verdict above rests on. In a row that differs, notes every code shares are dimmed.

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Derived from the official CMS ICD-10-CM tabular data (FY2027). A coding-rule comparison, not billing advice: payer-specific edits and medical-necessity policy are outside its scope. All data sources