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T88.6 vs T88.7XXD

T88.6 (Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered) compared with T88.7XXD (Unspecified adverse effect of drug or medicament, subsequent encounter), from the official CMS tabular data.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Summary

These codes should not be reported together because T88.7XXD’s tabular entry lists T88.6 under Excludes1.

Official rule
What is different?

The conditions named and billing status.T88.6 is “Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered”; T88.7XXD is “Unspecified adverse effect of drug or medicament, subsequent encounter”. T88.6 is a non-billable header; T88.7XXD is billable.

Registry fact

Can these codes be reported together?

No.T88.7XXD’s entry carries an Excludes1 note covering T88.6: “specified adverse effects of drugs and medicaments (A00-R94 and T80-T88.6, T88.8)”. Both may be reported only when the documentation shows the two conditions are unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Official ruleGuide: Excludes1 vs Excludes2

Is there an Excludes1 relationship?

Yes.T88.7XXD’s tabular entry: “specified adverse effects of drugs and medicaments (A00-R94 and T80-T88.6, T88.8)”. The note covers T88.6.

Official ruleGuide: Excludes1 vs Excludes2

Is one more specific?

Yes.T88.6’s title names the condition; T88.7XXD’s title is the unspecified form (“Unspecified adverse effect of drug or medicament, subsequent encounter”).

MedCoder-derivedGuide: Other vs unspecified (NEC vs NOS)

Is one a parent or header code?

One is a header.T88.6 is a non-billable header, but T88.7XXD is not one of its subdivisions.

Registry fact

Nothing found in 3 other checks
Is there an Excludes2 relationship?

None.Neither entry carries an Excludes2 note that names the other code. T88.6 carries 31 Excludes2 notes and T88.7XXD carries 31 Excludes2 notes covering other codes; the side-by-side table quotes them.

Official rule

Are there sequencing instructions?

None.Neither entry carries a Code First or Use Additional Code note that names the other.

Official rule

Are there other coding relationships?

None found.No laterality, encounter-phase, Table of Neoplasms, Table of Drugs and Chemicals, or history-versus-active-disease relationship links these codes.

MedCoder-derived

Official rule: a tabular instructional note or a section of the ICD-10-CM Official Guidelines, quoted as published. Registry fact: the codes’ own published attributes (titles, billable status, position in the hierarchy, code set). MedCoder-derived: a reading MedCoder computes from those facts; it is not itself a rule. How to read the labels

Can these codes be reported together?

Excludes1 — generally not reported together

Excludes1 conflict

T88.7XXD
Unspecified adverse effect of drug or medicament, subsequent encounter
↔
T88.6
Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered

What we found

No — do not report together.T88.7XXD carries an Excludes1 note covering T88.6: “specified adverse effects of drugs and medicaments (A00-R94 and T80-T88.6, T88.8)”

Sole exception: when the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

What to review

Report one of the two. Both may be reported only when the documentation shows the two conditions are unrelated to each other.

Guide: Excludes1 vs Excludes2Check these on a claim

Why it matters

An Excludes1 note means the two conditions are not ordinarily reported together for the same encounter, because the classification treats them as mutually exclusive forms of the same condition. The documented exception is when the two conditions are unrelated to each other.

Source / rule

CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a

Official guidance behind these answers

  • Section I.A.12.a — Excludes1 · applies to: Excludes1

    A type 1 Excludes note is a pure excludes note. It means “NOT CODED HERE!” An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition. An exception to the Excludes1 definition is the circumstance when the two conditions are unrelated to each other. If it is not clear whether the two conditions involving an Excludes1 note are related or not, query the provider. For example, code F45.8, Other somatoform disorders, has an Excludes1 note for "sleep related teeth grinding (G47.63)," because "teeth grinding" is an inclusion term under F45.8. Only one of these two codes should be assigned for teeth grinding. However psychogenic dysmenorrhea is also an inclusion term under F45.8, and a patient could have both this condition and sleep related teeth grinding. In this case, the two conditions are clearly unrelated to each other, and so it would be appropriate to report F45.8 and G47.63 together.

    ICD-10-CM Official Guidelines FY2027

Quoted from the ICD-10-CM Official Guidelines for Coding and Reporting in effect for the release shown. The tabular notes above are the code-level instruction; these sections are the convention that says how such a note is applied. Source document (CMS PDF) · Release and checksum

Side by side

Similar descriptions do not make codes interchangeable. The documentation and the official instructions decide which code applies.

Official descriptionDiffers
T88.6

Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered

T88.7XXD

Unspecified adverse effect of drug or medicament, subsequent encounter

StatusDiffers
T88.6
Non-billable header

A header is not reported on a claim; a code beneath it is.

Report instead: T88.6XXA, T88.6XXD, T88.6XXS

T88.7XXD
Billable
Excludes1Differs
T88.6
  • anaphylactic reaction due to serum (T80.5-)
  • anaphylactic shock or reaction due to adverse food reaction (T78.0-)
T88.7XXD
  • specified adverse effects of drugs and medicaments (A00-R94 and T80-T88.6, T88.8)
Excludes2Same for both
  • complication following infusion, transfusion and therapeutic injection (T80.-)
  • complication following procedure NEC (T81.-)
  • complications of anesthesia in labor and delivery (O74.-)
  • complications of anesthesia in pregnancy (O29.-)
  • complications of anesthesia in puerperium (O89.-)
  • complications of devices, implants and grafts (T82-T85)
  • complications of obstetric surgery and procedure (O75.4)
  • dermatitis due to drugs and medicaments (L23.3, L24.4, L25.1, L27.0-L27.1)
  • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4)
  • specified complications classified elsewhere
  • any encounters with medical care for postprocedural conditions in which no complications are present, such as:
  • artificial opening status (Z93.-)
  • closure of external stoma (Z43.-)
  • fitting and adjustment of external prosthetic device (Z44.-)
  • burns and corrosions from local applications and irradiation (T20-T32)
  • complications of surgical procedures during pregnancy, childbirth and the puerperium (O00-O9A)
  • mechanical complication of respirator [ventilator] (J95.850)
  • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4 or 6)
  • postprocedural fever (R50.82)
  • specified complications classified elsewhere, such as:
  • cerebrospinal fluid leak from spinal puncture (G97.0)
  • colostomy malfunction (K94.0-)
  • disorders of fluid and electrolyte imbalance (E86-E87)
  • functional disturbances following cardiac surgery (I97.0-I97.1)
  • intraoperative and postprocedural complications of specified body systems (D78.-, E36.-, E89.-, G97.3-, G97.4, H59.3-, H59.-, H95.2-, H95.3, I97.4-, I97.5, J95.6-, J95.7, K91.6-, L76.-, M96.-, N99.-)
  • ostomy complications (J95.0-, K94.-, N99.5-)
  • postgastric surgery syndromes (K91.1)
  • postlaminectomy syndrome NEC (M96.1)
  • postmastectomy lymphedema syndrome (I97.2)
  • postsurgical blind-loop syndrome (K91.2)
  • ventilator associated pneumonia (J95.851)
Use additional codeSame for both
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
  • code(s) to identify the specified condition resulting from the complication
  • code to identify devices involved and details of circumstances (Y62-Y82)
CategorySame for both

T88 Other complications of surgical and medical care, not elsewhere classified

ChapterSame for both

S00-T88 — Injury, Poisoning and Certain Other Consequences of External Causes (S00-T88)

IncludesDiffers
T88.6
  • Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
  • Anaphylactoid reaction NOS
T88.7XXD
  • Drug hypersensitivity NOS
  • Drug reaction NOS
7th characterSame for both
  • The appropriate 7th character is to be added to each code from category T88

No Code first and Code also note at either code.

Notes are the code’s own tabular entry, quoted as published. A note that names the other code is the one the verdict above rests on. In a row that differs, each code’s own notes are listed under it, and the notes every code shares are listed once beneath them.

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Derived from the official CMS ICD-10-CM tabular data (FY2027). A coding-rule comparison, not billing advice: payer-specific edits and medical-necessity policy are outside its scope. All data sources