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J0456 HCPCS Level II Code: Injection, azithromycin, 500 mg

Medicare Coverage & Payment

  • CMS short descriptor: Azithromycin
  • Medicare coverage: Special coverage instructions apply (CMS coverage code D)
  • Payment category: Drugs (pricing indicator 51)
  • BETOS: O1E — Other drugs
  • Last CMS action effective: January 1, 2000

Source: CMS HCPCS Level II release. Coverage codes indicate how Medicare treats the code, not whether a specific claim will be paid; payer policy and documentation still govern.

Code Overview

Injection, azithromycin, 500 mg is a HCPCS Level II code (J0456). CMS assigns coverage code D — Special coverage instructions apply. Short description: Azithromycin.

Summary composed by MedCoder from this code's official HCPCS Level II record. The tabular instructional notes themselves appear verbatim below.

Change history

  • 2000-01-01
    Added to the code set
    Injection, azithromycin, 500 mg

Drug products (NDC)

CMS ASP NDC-HCPCS Crosswalk · 2026 Q3

Medicare Part B payment limit (ASP + 6%): $1.89

00069-3150-83 Zithromax — Pfizer Inc (size 1 × qty 10 (500 MG per billing unit))

00409-0144-11 Azithromycin — Pfizer Inc (size 1 × qty 10 (500 MG per billing unit))

25021-0180-66 Azithromycin — Sagent Pharmaceuticals (size 1 × qty 10 (500 MG per billing unit))

55150-0174-10 Azithromycin — Eugia US LLC (size 1 × qty 10 (500 MG per billing unit))

63323-0398-10 Azithromycin — FreseniUS Kabi USA, LLC (size 1 × qty 10 (500 MG per billing unit))

63323-0398-14 Azithromycin — FreseniUS Kabi USA, LLC (size 1 × qty 10 (500 MG per billing unit))

70095-0025-02 Azithromycin — Sun Pharmaceutical Industries, Inc. (size 1 × qty 10 (500 MG per billing unit))

70436-0019-82 Azithromycin — Slate Run Pharmaceuticals (size 1 × qty 10 (500 MG per billing unit))

70860-0100-10 Azithromycin — Athenex Pharmaceutical Division, LLC (size 1 × qty 10 (500 MG per billing unit))

70860-0125-66 Azithromycin — Athenex Pharmaceutical Division, LLC (size 1 × qty 10 (500 MG per billing unit))

Related Codes

Poisoning, adverse-effect and underdosing codes for this drug

The ICD-10-CM Table of Drugs and Chemicals carries these diagnosis codes for this drug — a drug-name match derived from the CMS ASP crosswalk and the Table of Drugs and Chemicals, not a CMS-published pairing.

T36.3X1 — Poisoning by macrolides, accidental (unintentional), T36.3X2 — Poisoning by macrolides, intentional self-harm, T36.3X3 — Poisoning by macrolides, assault, T36.3X4 — Poisoning by macrolides, undetermined, T36.3X5 — Adverse effect of macrolides, T36.3X6 — Underdosing of macrolides

From the CMS ASP NDC-HCPCS Crosswalk and Part B Payment Limit File. Payment limits apply per HCPCS billing code, not per package.

Contextual Map

Every relationship of J0456 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Nearest codes (15)

  • J0400 — Injection, aripiprazole, intramuscular, 0.25 mg [Sibling]
  • J0401 — Injection, aripiprazole (abilify maintena), 1 mg [Sibling]
  • J0402 — Injection, aripiprazole (abilify asimtufii), 1 mg [Sibling]
  • J0457 — Injection, aztreonam, 100 mg [Sibling]
  • J0458 — Injection, aztreonam/avibactam, 7.5 mg/2.5 mg (10 mg) [Sibling]
  • J0461 — Injection, atropine sulfate, 0.01 mg [Sibling]
  • J0462 — Injection, atropine sulfate, not therapeutically equivalent to j0461, 0.01 mg [Sibling]
  • J0463 — Injection, atropine sulfate (fresenius and therapeutically equivalent), 0.01 mg [Sibling]
  • and 7 more

Change history

  • 2000-01-01 — Added to the code set [Change history]

Nearest Codes in This Family

Official HCPCS Level II classifications closest to J0456 in its code family, with their registry titles.

  • J0400 — Injection, aripiprazole, intramuscular, 0.25 mg
  • J0401 — Injection, aripiprazole (abilify maintena), 1 mg
  • J0402 — Injection, aripiprazole (abilify asimtufii), 1 mg
  • J0457 — Injection, aztreonam, 100 mg
  • J0458 — Injection, aztreonam/avibactam, 7.5 mg/2.5 mg (10 mg)
  • J0461 — Injection, atropine sulfate, 0.01 mg
  • J0462 — Injection, atropine sulfate, not therapeutically equivalent to j0461, 0.01 mg
  • J0463 — Injection, atropine sulfate (fresenius and therapeutically equivalent), 0.01 mg
  • J0470 — Injection, dimercaprol, per 100 mg
  • J0475 — Injection, baclofen, 10 mg