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A27.81 ICD-10-CM Code: Aseptic meningitis in leptospirosis

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Billing Status: YES. This is a valid, specific, and billable ICD-10-CM reference.

Billable · FY2027A valid, specific ICD-10-CM code, reportable for dates of service in FY2027.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too, and is marked with where it comes from.

The tabular list publishes no instructional note for this code itself.

Where it sits Source: CMS/NCHS

Under:Chapter 1: Certain Infectious and Parasitic DiseasesA20-A28 Certain zoonotic bacterial diseasesA27 LeptospirosisA27.8 Other forms of leptospirosis

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Inpatient Payment Groups (MS-DRG)

Potential MS-DRG participation — not a DRG assignment.

MS-DRGs this diagnosis helps define, as principal or secondary, per the CMS ICD-10-CM/PCS MS-DRG Definitions Manual v44, Appendix B.

  • MS-DRG 023 — CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITH MCC OR ANTINEOPLASTIC IMPLANT OR EPILEPSY WITH NEUROSTIMULATOR (MDC 01)
  • MS-DRG 024 — CRANIOTOMY WITH MAJOR DEVICE IMPLANT OR ACUTE COMPLEX CNS PRINCIPAL DIAGNOSIS WITHOUT MCC (MDC 01)
  • MS-DRG 097 — NON-BACTERIAL INFECTION OF NERVOUS SYSTEM EXCEPT VIRAL MENINGITIS WITH MCC (MDC 01)
  • MS-DRG 098 — NON-BACTERIAL INFECTION OF NERVOUS SYSTEM EXCEPT VIRAL MENINGITIS WITH CC (MDC 01)
  • MS-DRG 099 — NON-BACTERIAL INFECTION OF NERVOUS SYSTEM EXCEPT VIRAL MENINGITIS WITHOUT CC/MCC (MDC 01)

A diagnosis appearing in a group's logic does not by itself determine the DRG assigned to a stay; the grouper uses the full claim.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Aseptic meningitis in leptospirosis is a billable ICD-10-CM diagnosis code (A27.81).

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

  • MCC as a secondary diagnosis (FY2027). Can raise the stay's MS-DRG severity tier.

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name A27.81 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 1 Excludes1 note: G01 — Meningitis in bacterial diseases classified elsewhere.

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 6 Excludes2 notes: A65 — Nonvenereal syphilis (via A27.-), A65-A69 — Other spirochetal diseases (A65-A69) (via A27.-), A66 — Yaws (via A27.-), A67 — Pinta [carate] (via A27.-), A68 — Relapsing fevers (via A27.-), A69 — Other spirochetal infections (via A27.-).

These codes’ tabular lists name this diagnosis as distinct — both may be reported when both are documented.

MS-DRG Grouper Relationships (FY2027)

Potential MS-DRG participation — not a DRG assignment.

FY2027 MS-DRG: MCC — Major Complication or Comorbidity. Reported as a secondary diagnosis, this code raises the stay's MS-DRG severity tier — except when the principal diagnosis is one of 58 clinically related codes on its CMS exclusion list.

Named in the grouper logic of 5 MS-DRGs: DRG 023 (MDC 01), DRG 024 (MDC 01), DRG 097 (MDC 01), DRG 098 (MDC 01), DRG 099 (MDC 01).

From the CMS MS-DRG Definitions Manual (Appendices B and C). Actual DRG assignment depends on the complete claim.

Clinical classification (AHRQ CCSR):NVS001 — Meningitis (default); INF003 — Bacterial infections.

Clinical Classifications Software Refined (CCSR) for ICD-10-CM Diagnoses. Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality.

Related Codes

Same clinical process (MS-DRG)

Acts as MCC — raises the severity of other admissions. CMS groups these diagnoses into one MS-DRG principal-diagnosis exclusion process — a CC/MCC on this list never raises severity when the principal diagnosis is also on it.

A02.21 — Salmonella meningitis, A17.0 — Tuberculous meningitis, A17.1 — Meningeal tuberculoma, A27.0 — Leptospirosis icterohemorrhagica, A27.89 — Other forms of leptospirosis, A27.9 — Leptospirosis, unspecified, A39.0 — Meningococcal meningitis, A50.41 — Late congenital syphilitic meningitis, A51.41 — Secondary syphilitic meningitis, A52.13 — Late syphilitic meningitis, A54.82 — Gonococcal brain abscess, A54.84 — Gonococcal pneumonia, A54.89 — Other gonococcal infections, A54.9 — Gonococcal infection, unspecified, A74.81 — Chlamydial peritonitis, A74.89 — Other chlamydial diseases, A74.9 — Chlamydial infection, unspecified, A87.0 — Enteroviral meningitis, A87.1 — Adenoviral meningitis, A87.2 — Lymphocytic choriomeningitis, +37 more

Same clinical category (CCSR)

AHRQ's Clinical Classifications Software groups these diagnoses under the same clinical categories (Meningitis, Bacterial infections).

A01.01 — Typhoid meningitis, A02.21 — Salmonella meningitis, A17.0 — Tuberculous meningitis, A17.1 — Meningeal tuberculoma, A20.3 — Plague meningitis, A32.11 — Listerial meningitis, A39.0 — Meningococcal meningitis, A42.81 — Actinomycotic meningitis, A50.41 — Late congenital syphilitic meningitis, A51.41 — Secondary syphilitic meningitis, A52.13 — Late syphilitic meningitis, A54.81 — Gonococcal meningitis, A69.21 — Meningitis due to Lyme disease, A87.0 — Enteroviral meningitis, A87.1 — Adenoviral meningitis, A87.2 — Lymphocytic choriomeningitis, A87.8 — Other viral meningitis, A87.9 — Viral meningitis, unspecified, B00.3 — Herpesviral meningitis, B01.0 — Varicella meningitis, +413 more

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Meningitis”; these codes share that main term but sit in a different category of the Tabular List.

A01.01 — Typhoid meningitis (typhoid), A02.21 — Salmonella meningitis (Salmonella), A17.0 — Tuberculous meningitis (caseous), A20.3 — Plague meningitis (Yersinia pestis), A22.8 — Other forms of anthrax (in, anthrax), A32.11 — Listerial meningitis (in, Listeria monocytogenes), A37.90 — Whooping cough, unspecified species without pneumonia (in, whooping cough), A39.0 — Meningococcal meningitis (Neisseria), A42.81 — Actinomycotic meningitis (actinomycotic), A48.8 — Other specified bacterial diseases (in, bacterial disease NEC), A50.41 — Late congenital syphilitic meningitis (syphilitic, congenital), A51.41 — Secondary syphilitic meningitis (syphilitic, acute), A52.13 — Late syphilitic meningitis (syphilitic), A54.81 — Gonococcal meningitis (gonococcal), A69.21 — Meningitis due to Lyme disease (in, Lyme disease), A80.9 — Acute poliomyelitis, unspecified (poliovirus), A87.0 — Enteroviral meningitis (echovirus), A87.1 — Adenoviral meningitis (adenoviral), A87.2 — Lymphocytic choriomeningitis (lymphocytic), A87.8 — Other viral meningitis (arbovirus), +31 more

Contextual Map

Every relationship of A27.81 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run A27.81 with these 7 related codes in Claim Check

Hierarchy

Referenced by Excludes1 notes

Referenced by Excludes2 notes

  • A65 — Nonvenereal syphilis[Excludes2](via A27.-): “leptospirosis (A27.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2027
  • A65-A69 — Other spirochetal diseases (A65-A69)[Excludes2](via A27.-): “leptospirosis (A27.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2027
  • A66 — Yaws[Excludes2](via A27.-): “leptospirosis (A27.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2027
  • A67 — Pinta [carate][Excludes2](via A27.-): “leptospirosis (A27.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2027
  • A68 — Relapsing fevers[Excludes2](via A27.-): “leptospirosis (A27.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2027
  • A69 — Other spirochetal infections[Excludes2](via A27.-): “leptospirosis (A27.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2027

Clinical classification (CCSR)

MS-DRG Grouper

MDC crossing

  • MDC 01 — Diseases and Disorders of the Nervous System[MDC crossing]: “Diseases and Disorders of the Nervous System — the grouper's crossing between diagnoses and procedures: a principal diagnosis sets the MDC, and same-MDC procedures move the stay to its surgical DRGs. 8,919 same-MDC procedures group here; browse them on the MDC page.”— CMS MS-DRG Definitions Manual · FY2027

Index entries

  • Meningitis (basal) (basic) (brain) (cerebral) (cervical) (congestive) (diffuse) (hemorrhagic) (infantile) (membranous) (metastatic) (nonspecific) (pontine) (progressive) (simple) (spinal) (subacute) (sympathetic) (toxic), in (due to), leptospirosis[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027
  • Meningitis (basal) (basic) (brain) (cerebral) (cervical) (congestive) (diffuse) (hemorrhagic) (infantile) (membranous) (metastatic) (nonspecific) (pontine) (progressive) (simple) (spinal) (subacute) (sympathetic) (toxic), leptospiral (aseptic)[Index term]— CMS ICD-10-CM Index to Diseases and Injuries · icd10cm-fy2027

Nearest codes

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Indexed Clinical Terms (2)

Official source data — entries quoted as published, in the Index’s own lookup phrasing

Clinical term phrases from the official ICD-10-CM Index to Diseases and Injuries that map to this code. These are alphabetic-index entries shown as the Index writes them — lookup phrasing, not necessarily the wording of a final diagnosis.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Inpatient payment groups Official source data
CMS MS-DRG Definitions Manual (incl. Appendix B diagnosis index, Appendix C CC/MCC list, Appendix E procedure index) and IPPS Final Rule tables — v44 Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "A27.81 — Aseptic meningitis in leptospirosis." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/a27.81-aseptic-meningitis-in-leptospirosis

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Aseptic meningitis in leptospirosis

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to A27.81 in its code family, with their registry titles.

View all codes in the A27 family