C81 ICD-10-CM Code: Hodgkin lymphoma
Billing Status: NO. This is a clinician non-billable / parent hierarchy grouping in the ICD-10-CM system.
Coding at a Glance
- Tabular directives
- 1 Excludes1 · 4 Excludes2
Coding instructions
Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for C81 in the official ICD-10-CM tabular list, quoted as published.
Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2026Effective: October 1, 2025
Notes without a marker are published on C81 itself; “inherited from” names the category or block whose note applies here.
Excludes1 — Not Coded Here
Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).
- personal history of Hodgkin lymphoma (Z85.71) Compare C81 vs Z85.71 →
Excludes2 — Not Included Here
Conditions not covered by this code, but which may be reported alongside it when both are present.
- Kaposi's sarcoma of lymph nodes (C46.3) Compare C81 vs C46.3 →
- secondary and unspecified neoplasm of lymph nodes (C77.-) Compare C81 vs C77 →
- secondary neoplasm of bone marrow (C79.52) Compare C81 vs C79.52 →
- secondary neoplasm of spleen (C78.89) Compare C81 vs C78.89 →
Source: inherited from C81-C96
Coder workflow for C81
MedCoder structured workflow — derived from this code’s own official record
Before you code C81
- C81 is not reportable as written. Select the more specific code beneath it that the documentation supports. Codes are reported to the highest level of specificity the classification provides (Guidelines I.B.2).
ReviewC81.0, C81.1, C81.2, C81.3, C81.4, C81.7, C81.9
See the relationships section · Guide: How to choose an ICD-10-CM code →
- Confirm the documented site and behavior (this code’s block classifies malignant neoplasms), whether the site is primary or secondary, and whether the malignancy is current or a personal history: a previously excised malignancy with no further treatment and no evidence of disease is history, not current disease. Verify the site against the Table of Neoplasms. Neoplasm chapter guidelines (Guidelines I.C.2.a, I.C.2.d, I.C.2.m).
See the Table of Neoplasms entries · Guide: Active cancer vs history of cancer →
- Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with C81. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).
Choose the right path
- Does the documentation support one of the more specific codes beneath C81?
Yes → Select that code and continue the checks below on its own page.
No → C81 cannot be reported as written; query for the specificity its subcategory needs. - Does the documentation support a condition named in C81’s Excludes1 note?
Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
No → Continue.ReviewZ85.71
Consider C81. Then confirm the code is valid for the date of service in the Verify section.
Documentation check
- The provider’s diagnostic statement
- Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
- Anatomical site
- At the most specific level the record states; a site the classification separates cannot be assumed from a procedure or a measurement.
- Behavior and current-versus-history status
- Malignant, in situ, benign or uncertain; primary or secondary; current disease or personal history (Guidelines I.C.2.m).
Official instructions as workflow
Excludes1 — check before selecting C81(1 note)
Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with C81: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.
CompareZ85.71
See the official tabular notes · Guidelines I.A.12.a
Excludes2 — not part of C81(4 notes)
Coding workflow: The conditions named in this note are not included in C81. When the record documents both, both may be reported; the note is a boundary, not a prohibition.
CompareC46.3, C77, C79.52, C78.89
See the official tabular notes · Guidelines I.A.12.b
Coding decision scenarios
Pattern scenarios for this code’s structure — decision rules, not clinical cases
Documentation: Both the condition C81 describes and a condition named in its Excludes1 note are documented for the same encounter.
Coding question: Can both codes be reported?
Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.
Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).
ReviewZ85.71
Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.
Code Overview
MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.
Official Coding Guidelines
Official source data — quoted verbatim from the CMS/NCHS Official Guidelines
Official source data — quoted verbatim from the CMS/NCHS Official Guidelines
Verbatim excerpts from the ICD-10-CM Official Guidelines for Coding and Reporting (CMS/NCHS) that govern this code.
Chapter 2: Neoplasms (C00-D49 )
t. Secondary malignant neoplasm of lymphoid tissue When a malignant neoplasm of lymphoid tissue metastasizes beyond the lymph nodes, a code from categories C81-C85 with a final character identifying “extranodal and solid organ sites” should be assigned rather than a code for the secondary neoplasm of the affected solid organ. For example, for metastasis of diffuse large B-cell lymphoma to the lung, brain and left adrenal gland, assign code C83.398, Diffuse large B-cell lymphoma of other extranodal and solid organ sites.
Verify Before Coding
From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.
Relationships & Classification
MedCoder structured relationships — computed from published CMS and AHRQ datasets
Other codes that name C81 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.
Referenced by 3 Excludes1 notes: C26.1 — Malignant neoplasm of spleen, C76 — Malignant neoplasm of other and ill-defined sites, C77 — Secondary and unspecified malignant neoplasm of lymph nodes.
These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.
Referenced by 2 Code First instructions across 2 chapters: N16 — Renal tubulo-interstitial disorders in diseases classified elsewhere, Z15.0 — Genetic susceptibility to malignant neoplasm.
Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.
Contextual Map
Every relationship of C81 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.
Run C81 with these 9 related codes in Claim Check
Hierarchy
- C00-D49 — Chapter 2: Neoplasms (C00-D49) (C00-D49)[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- C81-C96 — Malignant neoplasms of lymphoid, hematopoietic and related tissue[Hierarchy]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
Excludes1
- Z85.71 — Personal history of Hodgkin lymphoma[Excludes1]: “personal history of Hodgkin lymphoma (Z85.71)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Excludes2
- C46.3 — Kaposi's sarcoma of lymph nodes[Excludes2]: “Kaposi's sarcoma of lymph nodes (C46.3)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- C77 — Secondary and unspecified malignant neoplasm of lymph nodes[Excludes2]: “secondary and unspecified neoplasm of lymph nodes (C77.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- C78.89 — Secondary malignant neoplasm of other digestive organs[Excludes2]: “secondary neoplasm of spleen (C78.89)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- C79.52 — Secondary malignant neoplasm of bone marrow[Excludes2]: “secondary neoplasm of bone marrow (C79.52)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Referenced by Excludes1 notes
- C26.1 — Malignant neoplasm of spleen[Excludes1]: “Hodgkin lymphoma (C81.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- C76 — Malignant neoplasm of other and ill-defined sites[Excludes1]: “malignant neoplasm of lymphoid, hematopoietic and related tissue (C81-C96)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- C77 — Secondary and unspecified malignant neoplasm of lymph nodes[Excludes1]: “malignant neoplasm of lymph nodes, specified as primary (C81-C86, C88, C96.-)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Referenced by Code First instructions
- N16 — Renal tubulo-interstitial disorders in diseases classified elsewhere[Code First]: “lymphoma (C81.0-C85.9, C96.0-C96.9)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
- Z15.0 — Genetic susceptibility to malignant neoplasm[Code First]: “, if applicable, any current malignant neoplasm (C00-C75, C81-C96)”— CMS ICD-10-CM tabular instructional notes · icd10cm-fy2026
Nearest codes (84)
- C81.0 — Nodular lymphocyte predominant Hodgkin lymphoma[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- C81.00 — Nodular lymphocyte predominant Hodgkin lymphoma, unspecified site[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- C81.01 — Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of head, face, and neck[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- C81.02 — Nodular lymphocyte predominant Hodgkin lymphoma, intrathoracic lymph nodes[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- C81.03 — Nodular lymphocyte predominant Hodgkin lymphoma, intra-abdominal lymph nodes[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- C81.04 — Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of axilla and upper limb[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- C81.05 — Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of inguinal region and lower limb[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- C81.06 — Nodular lymphocyte predominant Hodgkin lymphoma, intrapelvic lymph nodes[Sibling]— CMS ICD-10-CM tabular structure · icd10cm-fy2026
- and 76 more
Change history
- FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016
Common coding questions
Can C81 be billed directly?
No. C81 (Hodgkin lymphoma) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.
Sources for this page
Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.
- Code, title, tabular notes and index terms Official source data
- CMS/CDC ICD-10-CM FY2026 tabular list, index and tables, effective October 1, 2025 Release, file and checksum · Publisher’s page
- Coding guidelines Official source data
- ICD-10-CM Official Guidelines for Coding and Reporting (FY2026), quoted by section Release, file and checksum · Publisher’s page
- Claim edits Official source data
- CMS Definitions of Medicare Code Edits — v43.1 (April 2026) Release, file and checksum · Publisher’s page
- Change history and date-of-service validity Official source data
- CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
- Comparisons, relationships and the contextual map MedCoder structured relationship
- Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
- Summary and FAQ answers MedCoder explanation
- Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.
Labels on this page: Official source data · MedCoder structured relationship · MedCoder explanation. How to read the labels · All data sources and release dates
Cite this page
Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.
MedCoder.ai. "C81 — Hodgkin lymphoma." ICD-10-CM FY2026. https://medcoder.ai/icd10/code/c81-hodgkin-lymphoma
Change history
- FY2016 — October 1, 2015In the code set at ICD-10-CM adoptionHodgkin lymphoma
No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027 (effective October 1, 2026), and none are recorded for this code. Note changes are tracked from FY2027 only.
Nearest Codes in This Family
Official ICD-10-CM classifications closest to C81 in its code family, with their registry titles.
- C81.0 — Nodular lymphocyte predominant Hodgkin lymphoma
- C81.00 — Nodular lymphocyte predominant Hodgkin lymphoma, unspecified site
- C81.01 — Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.02 — Nodular lymphocyte predominant Hodgkin lymphoma, intrathoracic lymph nodes
- C81.03 — Nodular lymphocyte predominant Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.04 — Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.05 — Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.06 — Nodular lymphocyte predominant Hodgkin lymphoma, intrapelvic lymph nodes
- C81.07 — Nodular lymphocyte predominant Hodgkin lymphoma, spleen
- C81.08 — Nodular lymphocyte predominant Hodgkin lymphoma, lymph nodes of multiple sites
- C81.09 — Nodular lymphocyte predominant Hodgkin lymphoma, extranodal and solid organ sites
- C81.0A — Nodular lymphocyte predominant Hodgkin lymphoma, in remission
- C81.1 — Nodular sclerosis Hodgkin lymphoma
- C81.10 — Nodular sclerosis Hodgkin lymphoma, unspecified site
- C81.11 — Nodular sclerosis Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.12 — Nodular sclerosis Hodgkin lymphoma, intrathoracic lymph nodes
- C81.13 — Nodular sclerosis Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.14 — Nodular sclerosis Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.15 — Nodular sclerosis Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.16 — Nodular sclerosis Hodgkin lymphoma, intrapelvic lymph nodes
- C81.17 — Nodular sclerosis Hodgkin lymphoma, spleen
- C81.18 — Nodular sclerosis Hodgkin lymphoma, lymph nodes of multiple sites
- C81.19 — Nodular sclerosis Hodgkin lymphoma, extranodal and solid organ sites
- C81.1A — Nodular sclerosis Hodgkin lymphoma, in remission
- C81.2 — Mixed cellularity Hodgkin lymphoma
- C81.20 — Mixed cellularity Hodgkin lymphoma, unspecified site
- C81.21 — Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.22 — Mixed cellularity Hodgkin lymphoma, intrathoracic lymph nodes
- C81.23 — Mixed cellularity Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.24 — Mixed cellularity Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.25 — Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.26 — Mixed cellularity Hodgkin lymphoma, intrapelvic lymph nodes
- C81.27 — Mixed cellularity Hodgkin lymphoma, spleen
- C81.28 — Mixed cellularity Hodgkin lymphoma, lymph nodes of multiple sites
- C81.29 — Mixed cellularity Hodgkin lymphoma, extranodal and solid organ sites
- C81.2A — Mixed cellularity Hodgkin lymphoma, in remission
- C81.3 — Lymphocyte depleted Hodgkin lymphoma
- C81.30 — Lymphocyte depleted Hodgkin lymphoma, unspecified site
- C81.31 — Lymphocyte depleted Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.32 — Lymphocyte depleted Hodgkin lymphoma, intrathoracic lymph nodes
- C81.33 — Lymphocyte depleted Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.34 — Lymphocyte depleted Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.35 — Lymphocyte depleted Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.36 — Lymphocyte depleted Hodgkin lymphoma, intrapelvic lymph nodes
- C81.37 — Lymphocyte depleted Hodgkin lymphoma, spleen
- C81.38 — Lymphocyte depleted Hodgkin lymphoma, lymph nodes of multiple sites
- C81.39 — Lymphocyte depleted Hodgkin lymphoma, extranodal and solid organ sites
- C81.3A — Lymphocyte depleted Hodgkin lymphoma, in remission
- C81.4 — Lymphocyte-rich Hodgkin lymphoma
- C81.40 — Lymphocyte-rich Hodgkin lymphoma, unspecified site
- C81.41 — Lymphocyte-rich Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.42 — Lymphocyte-rich Hodgkin lymphoma, intrathoracic lymph nodes
- C81.43 — Lymphocyte-rich Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.44 — Lymphocyte-rich Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.45 — Lymphocyte-rich Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.46 — Lymphocyte-rich Hodgkin lymphoma, intrapelvic lymph nodes
- C81.47 — Lymphocyte-rich Hodgkin lymphoma, spleen
- C81.48 — Lymphocyte-rich Hodgkin lymphoma, lymph nodes of multiple sites
- C81.49 — Lymphocyte-rich Hodgkin lymphoma, extranodal and solid organ sites
- C81.4A — Lymphocyte-rich Hodgkin lymphoma, in remission
- C81.7 — Other Hodgkin lymphoma
- C81.70 — Other Hodgkin lymphoma, unspecified site
- C81.71 — Other Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.72 — Other Hodgkin lymphoma, intrathoracic lymph nodes
- C81.73 — Other Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.74 — Other Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.75 — Other Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.76 — Other Hodgkin lymphoma, intrapelvic lymph nodes
- C81.77 — Other Hodgkin lymphoma, spleen
- C81.78 — Other Hodgkin lymphoma, lymph nodes of multiple sites
- C81.79 — Other Hodgkin lymphoma, extranodal and solid organ sites
- C81.7A — Other Hodgkin lymphoma, in remission
- C81.9 — Hodgkin lymphoma, unspecified
- C81.90 — Hodgkin lymphoma, unspecified, unspecified site
- C81.91 — Hodgkin lymphoma, unspecified, lymph nodes of head, face, and neck
- C81.92 — Hodgkin lymphoma, unspecified, intrathoracic lymph nodes
- C81.93 — Hodgkin lymphoma, unspecified, intra-abdominal lymph nodes
- C81.94 — Hodgkin lymphoma, unspecified, lymph nodes of axilla and upper limb
- C81.95 — Hodgkin lymphoma, unspecified, lymph nodes of inguinal region and lower limb
- C81.96 — Hodgkin lymphoma, unspecified, intrapelvic lymph nodes
- C81.97 — Hodgkin lymphoma, unspecified, spleen
- C81.98 — Hodgkin lymphoma, unspecified, lymph nodes of multiple sites
- C81.99 — Hodgkin lymphoma, unspecified, extranodal and solid organ sites
- C81.9A — Hodgkin lymphoma, unspecified, in remission