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C95.0 ICD-10-CM Code: Acute leukemia of unspecified cell type

Compare with another code for C95.0Check this code on a claim

Billing Status: NO. This is a non-billable ICD-10-CM code: report a more specific billable code beneath it.

Coding at a Glance

Tabular directives
4 inclusion terms · 2 Excludes1 · 4 Excludes2

Not billable · FY2027A non-billable heading in the tabular list: report a more specific code beneath it.

What you need to know

Source: CMS/NCHS Official ICD-10-CM tabular notes, quoted. From the CMS/NCHS tabular list for the release in force. A note the category or block publishes applies to this code too, and is marked with where it comes from.

Excludes1Not reported with this code unless documented as unrelated
  • acute exacerbation of unspecified chronic leukemia (C95.10)
  • personal history of leukemia (Z85.6) (from C95)
Excludes2from C81-C96Not included here; may be reported together
  • Kaposi's sarcoma of lymph nodes (C46.3)
  • secondary and unspecified neoplasm of lymph nodes (C77.-)
  • secondary neoplasm of bone marrow (C79.52)
  • secondary neoplasm of spleen (C78.89)
IncludesWhat this code covers
  • Acute bilineal leukemia
  • Acute mixed lineage leukemia
  • Biphenotypic acute leukemia
  • Stem cell leukemia of unclear lineage

Where it sits Source: CMS/NCHS

Under:Chapter 2: NeoplasmsC00-C96 Malignant neoplasmsC81-C96 Malignant neoplasms of lymphoid, hematopoietic and related tissueC95 Leukemia of unspecified cell type

Codes under C95.0 (3)

  • C95.00Acute leukemia of unspecified cell type not having achieved remissionBillable
  • C95.01Acute leukemia of unspecified cell type, in remissionBillable
  • C95.02Acute leukemia of unspecified cell type, in relapseBillable

Most relevant related codes MedCoder-derived

Read off the official notes above and this code’s own position in the tabular list. Which to report is a documentation question; Compare shows the two side by side.

CompareCheck ClaimView Related Codes

Coding instructions

Official Tabular Instructional Notes: the inclusion, exclusion and sequencing notes published for C95.0 in the official ICD-10-CM tabular list, quoted as published.

Source: CMS/CDC — ICD-10-CM Tabular ListRelease: FY2027Effective: October 1, 2026

Trace:FY2027 changesChange historyRelease, file and checksum

Notes without a marker are published on C95.0 itself; “inherited from” names the category or block whose note applies here.

Inclusion Terms

Alternative terms the tabular list files under this code.

  • Acute bilineal leukemia
  • Acute mixed lineage leukemia
  • Biphenotypic acute leukemia
  • Stem cell leukemia of unclear lineage

Excludes1 — Not Coded Here

Conditions generally not reported together with this code (Excludes1) -- an error unless the two conditions are documented as unrelated to each other (ICD-10-CM Official Guidelines, Section I.A.12.a).

Excludes2 — Not Included Here

Conditions not covered by this code, but which may be reported alongside it when both are present.

Source: inherited from C81-C96

Coder workflow for C95.0

MedCoder structured workflow — derived from this code’s own official record

Before you code C95.0

  1. C95.0 is not reportable as written. Select the more specific code beneath it that the documentation supports. Codes are reported to the highest level of specificity the classification provides (Guidelines I.B.2).

    ReviewC95.00, C95.01, C95.02

    See the relationships section · Guide: How to choose an ICD-10-CM code →

  2. Confirm the documented site and behavior (this code’s block classifies malignant neoplasms), whether the site is primary or secondary, and whether the malignancy is current or a personal history: a previously excised malignancy with no further treatment and no evidence of disease is history, not current disease. Verify the site against the Table of Neoplasms. Neoplasm chapter guidelines (Guidelines I.C.2.a, I.C.2.d, I.C.2.m).

    See the Table of Neoplasms entries · Guide: Active cancer vs history of cancer →

  3. Check the Excludes1 note: if the documentation supports a condition named there, do not simply proceed with the code beneath C95.0. Excludes1 conditions are not reported together with this code unless the record shows they are unrelated (Guidelines I.A.12.a).

    See the official tabular notes

Choose the right path

  1. Does the documentation support one of the more specific codes beneath C95.0?
    Yes → Select that code and continue the checks below on its own page.
    No → C95.0 cannot be reported as written. Where the codes beneath it include an unspecified code, that code applies when the record goes no further; otherwise query for the missing detail.

    ReviewC95.00, C95.01, C95.02

  2. Does the documentation support a condition named in C95.0’s Excludes1 note?
    Yes → Do not simply proceed: review the excluded code. Both are reported only when the record shows the two conditions are unrelated.
    No → Continue.

    ReviewC95.10, Z85.6

Report the code beneath C95.0 that the documentation supports, not C95.0 itself. Then confirm that code is valid for the date of service on its own page.

Documentation check

The provider’s diagnostic statement
Codes are assigned from the provider’s documented diagnosis, not from clinical criteria, test values or a medication list (Guidelines I.A.19).
Anatomical site
At the most specific level the record states; a site the classification separates cannot be assumed from a procedure or a measurement.
Acuity
Acute or chronic as documented; when both are documented and separate codes exist, both are reported with the acute code first (Guidelines I.B.8).
Behavior and current-versus-history status
Malignant, in situ, benign or uncertain; primary or secondary; current disease or personal history (Guidelines I.C.2.m).
Any detail beyond this code’s title
What the record states that a more specific code would capture — or its absence, which itself supports the unspecified code.

Official instructions as workflow

  • Excludes1 — check before selecting C95.0(2 notes)

    Coding workflow: If the documentation supports a condition named in this note, do not simply proceed with C95.0: the two are not reported together. The one exception is when the record shows the two conditions are unrelated to each other.

    CompareC95.10, Z85.6

    See the official tabular notes · Guidelines I.A.12.a

  • Excludes2 — not part of C95.0(4 notes)

    Coding workflow: The conditions named in this note are not included in C95.0. When the record documents both, both may be reported; the note is a boundary, not a prohibition.

    CompareC46.3, C77, C79.52, C78.89

    See the official tabular notes · Guidelines I.A.12.b

Coding decision scenarios

Pattern scenarios for this code’s structure — decision rules, not clinical cases

Documentation: The provider documents the condition in the terms of this code’s title and records no further detail.

Coding question: Is a more specific code supportable?

Path: No sibling in this subcategory is more specific; look the documented detail up in the Alphabetic Index.

Reason: A more specific code needs documentation of the distinguishing element; without it the unspecified code is appropriate, and a provider query is the route to specificity (Guidelines I.A.9.b, I.B.18).

Documentation: Both the condition C95.0 describes and a condition named in its Excludes1 note are documented for the same encounter.

Coding question: Can both codes be reported?

Path: Review the Excludes1 note and the excluded code, and look for a provider statement on whether the two conditions are related.

Reason: Excludes1 means the two are not coded together; the exception is when the record shows the conditions are unrelated to each other (Guidelines I.A.12.a).

ReviewC95.10, Z85.6

Every row is derived from this code’s own record — its title, tabular notes, 7th-character family and same-category siblings — with fixed MedCoder wording; nothing is inferred about a patient. The official notes and guideline text are in the sections each row links to, and they control.

Don’t confuse C95.0 with…

MedCoder analysis — pairs from this code’s official notes, distinctions written by MedCoder

The codes most likely to be picked instead of C95.0 — named in its own official notes, or sharing its laterality or encounter family — with what separates them and which documentation moves the case. Each links to the full comparison.

  • C95.10— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of acute exacerbation of unspecified chronic leukemia moves the case to C95.10; the two are not reported together unless documented as unrelated.

    Full comparison: C95.0 vs C95.10 →

  • Z85.6— Excludes1 conflict (Excludes1 — generally not reported together)

    Not coded here — the tabular list excludes this pair for the same encounter.

    Not reported together with this code, except where the two conditions are documented as unrelated.

    What moves you there: Documentation of personal history of leukemia moves the case to Z85.6; the two are not reported together unless documented as unrelated.

    Full comparison: C95.0 vs Z85.6 →

  • C46.3— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of Kaposi's sarcoma of lymph nodes adds C46.3; it is not part of this code and both may be reported when both are documented.

    Full comparison: C95.0 vs C46.3 →

  • C77— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of secondary and unspecified neoplasm of lymph nodes adds C77; it is not part of this code and both may be reported when both are documented.

    Full comparison: C95.0 vs C77 →

  • C79.52— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of secondary neoplasm of bone marrow adds C79.52; it is not part of this code and both may be reported when both are documented.

    Full comparison: C95.0 vs C79.52 →

  • C78.89— Excludes2 relationship (Informational)

    Distinct conditions — both may be reported.

    A distinct condition — both may be reported when both are documented.

    What moves you there: Documentation of secondary neoplasm of spleen adds C78.89; it is not part of this code and both may be reported when both are documented.

    Full comparison: C95.0 vs C78.89 →

Relationships are read from this code's own official notes, its laterality siblings and its encounter family; the wording of each distinction is MedCoder editorial, and the documentation named in each “what moves you there” line is the official note phrase or sibling title itself. Source: CMS ICD-10-CM tabular instructional notes; ICD-10-CM Official Guidelines, Section I.A.12.a.

Coding context

Guidelines, coding notes, decision aids, relationships (with MS-DRG and CCSR classification), hierarchy, HCC, coverage and the context map: what a coder reaches for after the core. Each section names whether it is official source data, a MedCoder-derived relationship or MedCoder editorial.

Code Overview

Acute leukemia of unspecified cell type is a non-billable ICD-10-CM category code (C95.0). A more specific billable subcode must be selected for claims submission.

MedCoder summary Summary composed by MedCoder from this code's official ICD-10-CM record. The tabular instructional notes themselves appear verbatim below.

Verify Before Coding

From the code registry, the Medicare Code Editor, and the MS-DRG Definitions Manual. Check it against a full claim in Claim Check.

Relationships & Classification

MedCoder-derived relationships — computed from published CMS and AHRQ datasets

Other codes that name C95.0 or its code family, from the CMS ICD-10-CM tabular instructional notes. Tabular-note edges are stored at the code family level that carries each note.

Referenced by 5 Excludes1 notes across 4 chapters: C76 — Malignant neoplasm of other and ill-defined sites (via C95.-), D72.8 — Other specified disorders of white blood cells (via C95.-), D72.825 — Bandemia (via C95.-), T66 — Radiation sickness, unspecified (via C95.-), Z85.6 — Personal history of leukemia (via C95.-).

These codes’ tabular lists mark this diagnosis as mutually exclusive — not reported together unless the conditions are documented as unrelated.

Referenced by 4 Code First instructions across 4 chapters: M36.1 — Arthropathy in neoplastic disease (via C95.-), N16 — Renal tubulo-interstitial disorders in diseases classified elsewhere (via C95.-), R50.81 — Fever presenting with conditions classified elsewhere (via C95.-), Z15.0 — Genetic susceptibility to malignant neoplasm (via C95.-).

Each of these codes carries a Code First note naming this condition — when that code is reported, THIS code is sequenced first, ahead of it.

Related Codes

Same Index main term, other category

The ICD-10-CM Index to Diseases and Injuries files this code under the main term “Leukemia, leukemic”; these codes share that main term but sit in a different category of the Tabular List.

C91.Z — Other lymphoid leukemia (lymphoid, specified NEC), C92.0 — Acute myeloblastic leukemia (AML), C92.1 — Chronic myeloid leukemia, BCR/ABL-positive (chronic myelogenous), C92.2 — Atypical chronic myeloid leukemia, BCR/ABL-negative (atypical chronic myeloid, BCR/ABL-negative), C92.4 — Acute promyelocytic leukemia (AML M3), C92.5 — Acute myelomonocytic leukemia (AML M4), C92.6 — Acute myeloid leukemia with 11q23-abnormality (acute myeloid, NOS, with, 11q23-abnormality), C92.9 — Myeloid leukemia, unspecified (myeloid), C92.A — Acute myeloid leukemia with multilineage dysplasia (acute myeloid, NOS, with, multilineage dysplasia), C92.Z — Other myeloid leukemia (myeloid, specified NEC), C93.0 — Acute monoblastic/monocytic leukemia (AML M5), C93.1 — Chronic myelomonocytic leukemia (CMML), C93.3 — Juvenile myelomonocytic leukemia (juvenile myelomonocytic), C93.9 — Monocytic leukemia, unspecified (monocytic), C93.Z — Other monocytic leukemia (monocytic, specified NEC), C94.0 — Acute erythroid leukemia (acute erythroid), C94.2 — Acute megakaryoblastic leukemia (acute megakaryocytic), C94.3 — Mast cell leukemia (mast cell), C94.8 — Other specified leukemias (specified NEC), D47.1 — Chronic myeloproliferative disease (chronic neutrophilic), +9 more

Contextual Map

Every relationship of C95.0 in one view: hierarchy, official tabular instructions in both directions, clinical classification, risk adjustment, MS-DRG participation, index terms and change history — each edge carrying the CMS source it derives from.

Run C95.0 with these 10 related codes in Claim Check

Hierarchy

Excludes1

Referenced by Excludes1 notes

Referenced by Code First instructions

Nearest codes (12)

Change history

  • FY2016 — In the code set at ICD-10-CM adoption [Change history]— CMS release files (code change ledger) · icd10cm-fy2016

Reference

Index terms and tables, published questions and FAQ, every source behind this page with its release and checksum, the date-of-service check and the complete change history.

Common coding questions

MedCoder editorial

Can C95.0 be billed directly?

No. C95.0 (Acute leukemia of unspecified cell type) is a non-billable ICD-10-CM category code. A more specific billable subcode must be selected based on clinical documentation.

Sources for this page

Codes, titles, notes, index terms and mappings on this page are transcribed from the datasets below. Relationships MedCoder computed and text MedCoder wrote are labelled where they appear.

Code, title, tabular notes and index terms Official source data
CMS/CDC ICD-10-CM FY2027 tabular list, index and tables, effective October 1, 2026 Release, file and checksum · Publisher’s page
Claim edits Official source data
CMS Definitions of Medicare Code Edits — v44.0 (October 2026) Release, file and checksum · Publisher’s page
Change history and date-of-service validity Official source data
CMS ICD-10-CM release addenda, ingested release by release into the change ledger Release, file and checksum · Publisher’s page
Comparisons, relationships and the contextual map MedCoder-derived relationship
Computed by MedCoder from the tabular notes and tables above; every derived relationship is marked as derived where it appears
Summary and FAQ answers MedCoder editorial explanation
Written by MedCoder to explain the sources above: drafted with AI assistance, checked by a person against the release files, and labelled as MedCoder text where it appears. Not official text.

Current data releases:ICD-10-CM FY2027 · ICD-10-PCS FY2027 · HCPCS October 2026 · MS-DRG v44 · Medicare Code Editor v44.0 · NCCI PTP Q4 2026 · MUE Q4 2026 · NCD code lists 2026-01 · LCD export September 28, 2026 · All releases and sources

Labels on this page: Official source data · MedCoder-derived relationship · MedCoder editorial explanation. How to read the labels · All data sources and release dates · CMS coding rules

Cite this page

Reference this page in a research guide, syllabus or article. The release is included because code content changes each year.

MedCoder.ai. "C95.0 — Acute leukemia of unspecified cell type." ICD-10-CM FY2027. https://medcoder.ai/icd10/code/c95.0-acute-leukemia-of-unspecified-cell-type

Change history

  • FY2016 — October 1, 2015
    In the code set at ICD-10-CM adoption
    Acute leukemia of unspecified cell type

No changes since FY2016 — additions, deletions, description changes and billable-status changes are tracked through FY2027, and none are recorded for this code. Note changes are tracked from FY2027 only.

Nearest Codes in This Family

Official ICD-10-CM classifications closest to C95.0 in its code family, with their registry titles.

View all codes in the C95 family